The high-strength steel frame with D-eccentric brace presents a novel structural system that demonstrates exceptional plastic deformation capabilities when exposed to high levels of earthquake hazards. This system employs ordinary steel links with a yield strength below 345 MPa, while the frame beam and column utilize high-strength steel (yield strength above 460 MPa, such as Q460 or Q690 steel) to reduce cross-sectional dimensions while ensuring elasticity of non-energy consuming components. The resulting structure exhibits outstanding ductility and energy-dissipating capacity. The response modification factor (R), a crucial parameter in performance-based seismic design, plays a significant role in achieving appropriate and cost-effective seismic designs. Unfortunately, the 2016 edition of China's code for Seismic Design of Buildings (GB50011-2010) did not consider the concept of R and instead employed a constant value for all structural systems, which is unreasonable. Therefore, a comprehensive investigation of the R value for the high-strength steel frame with D-eccentric brace is imperative to enhance structural performance design, provide guidance for future designs, and promote the widespread implementation of this structure in seismic regions, where it exhibits superior seismic performance. This study utilizes the performance-based seismic design approach to design structures with varying numbers of stories (4, 8, and 12), link lengths (900, 1000, and 1100 mm), and different steel strengths (Q460 and Q690). An improved pushover analysis method is employed to calculate the R values for each prototype, considering the number of structural stories (N) and the link length (e). The derived values of each performance coefficient serve as valuable references for future performance designs of novel structural systems.