Young adults with Attention Deficit Hyperactivity Disorder (ADHD) have higher fracture rates than healthy adults. While exercise is recommended for people with ADHD to alleviate hyperactivity-impulsivity, little is known about the relationship between exercise and fracture in this population. PURPOSE: To explore the association between exercise and fractures in young adults with ADHD, not using medication. METHODS: We performed a retrospective analysis of data of young adults with ADHD treated at the University of Alabama at Birmingham Health Systems. We selected a case if an individual was previously diagnosed with ADHD using ICD-10 code F90 and ages between 21 and 35 years. The comparison group were individuals with ADHD and have not had a fracture within the same age limits. The outcome variable was whether a patient with ADHD diagnosed with a fracture or not during this period. Exercise files included data about exercise status (i.e., yes or no), frequency (i.e., low, moderate, or high), and type (i.e., aerobics or non-aerobics). Exercise assessment was within the year before the fracture date for fracture group and within the year before data acquisition for the non-fracture group. We ran a multivariable logistic regression analysis to test the association between fractures and 1) exercise status, 2) exercise frequency, and 3) exercise type, controlling for sex. We analyzed the data using STATA SE 15.1. RESULTS: Our analyses included 296 persons with a mean age of 27.29 ± 4.17 years for the comparison group and 28.0 ± 3.58 years for the fracture group. The mean age of fracture in the fracture group was 25.09 ± 3.45. Also, the logistic regression that was controlled for sex, showed that individuals who exercised had significantly lower odds of having a fracture compare to those that reported no exercise [OR: 0.14, 95% CI: 0.08, 0.27]. Of those, females compared to males, were also significantly associated with sustaining fewer fractures, controlling for exercise status [OR: 2.86, 95% CI: 1.53, 5.35]. Finally, exercise frequency and exercise type were not significantly associated with fracture risk. CONCLUSIONS: Engaging in exercise might decrease the odds of sustaining a fracture in young adults with ADHD. Exercise needs to be studied more in young adults with ADHD to determine how exercise may protect against fractures.