Fractures In Dogs Research Articles

Total hip arthroplasty for femoral fractures other than capital physeal fractures in dogs: 14 cases (2012-2020).

The goals of this retrospective study were to assess the clinical and radiographic outcomes in dogs with proximal femoral fractures, other than capital physeal fractures, treated via total hip arthroplasty. Medical records as well as pre-operative, immediate post-operative and 2 to 3 months post-operative radiographs of 14 dogs with femoral head and neck fractures treated via total hip arthroplasty were reviewed. A Liverpool Osteoarthritis in Dogs questionnaire was completed by owners to assess long-term outcomes. Seven femoral head fractures, and seven femoral neck fractures were included. Four of the femoral head fractures were acute in nature, the three remaining femoral head fractures and all seven femoral neck fracture cases were chronic fractures. Malorientation of the femoral stem was more common in the chronic femoral fracture cases when compared to the acute femoral fracture cases. Two of the acute fracture cases and five chronic fracture cases experienced a change in femoral stem position post-operatively. One femoral fissure fracture occurred and was repaired intraoperatively. One case had a post-operative complication that resulted in implant removal. All dogs had good to excellent owner-perceived outcome. Femoral head and neck fractures, and in particular the chronic cases, represented a challenging subset of cases presenting for total hip arthroplasty, resulting in suboptimal stem alignment in many cases. However, clinical outcomes were considered good to excellent in all dogs in the study, indicating that total hip arthroplasty is a viable treatment option for these types of fractures.

Clinical experience and outcomes using a commercially available micro-plating system for metabone fractures in dogs and cats: 10 cases (2019-2023).

To report the clinical experience and long-term outcome following metabone fracture stabilisation using a commercially available micro-plating system (VetKISS, 1.0-mm, IMEX Veterinary, USA). Consecutive, client-owned cats and dogs weighing <7 kg, with traumatic metabone fractures stabilised using VetKISS micro-plates were prospectively enrolled with informed owner consent. Clinical and radiographic parameters were recorded. Either short-term or long-term clinical and radiographic follow-up was required for study inclusion. Four cats and six dogs were enrolled and operated by one of two board-certified surgeons. Bodyweight ranged from 1.9 to 6.6 kg. Number of metabones fractured: all four (60%), three (30%) and two (10%). Anatomical alignment was restored for each metabone. External coaptation was not used in any case. Radiographic follow-up documented clinical or bony union in all cases. Mean time to clinical union was 51 days. One major complication (screw removal) and two minor complications (partial construct failure) were observed. All patients made a complete functional recovery at the time of documented union. Long-term follow-up was available in five cases. No lameness (evaluated independently by both surgeons) or plate sensitivity was noted. This is the first clinical evaluation of the VetKISS for metabone fracture repair, and includes long-term follow-up. Results demonstrated complete functional recovery and 100% clinical union rates in all patients, with acceptable complication rates. This system can be considered for metabone repair in patients weighing <7 kg without the use of external coaptation.

Computed tomography-derived structural analysis for the likelihood of pathologic fracture in canine antebrachial osteosarcoma.

Determining the risk of pathologic fracture in dogs with a primary bone tumor would aid in case selection for in-situ treatment options. Prior research found strong relationships between in vitro strength of canine antebrachii with primary bone tumors and CT-derived metrics. This study assesses the prognosis for pathologic fracture in dogs with distal radial bone tumors using CT-derived structural analysis metrics. CT images of the antebrachium in dogs with aggressive osseous lesions of the radius were used to calculate structural rigidity and failure forces, including axial rigidity (AR), craniocaudal bending rigidity (BR), torsional rigidity (TR), and failure forces for a slightly-curved/asymmetric beam (Fs) or a curved beam (Fc). Metrics were compared with the clinical outcome of radial fracture. Eight of 19 dogs with CT-derived metrics developed a radial fracture. The prognostic potential of the metrics to discriminate fractured and nonfractured bones was analyzed using receiver operating characteristic curves (area under the curve), stepwise logistic regression, and classification regression (CART) analyses. Fc was the most sensitive and specific metric for prognosing fracture occurrence (AUC=0.864). When dog body weight (BW) was included, all five metrics had AUC>0.705. Fc was the best predictor of fracture using stepwise logistic regression and CART analysis, followed by BR. An indication of fracture probability can be determined by normalizing Fc or BR with dog BW or by using the logistic regression equation of either metric with dog BW. Results warrant further analysis of a larger cohort to evaluate fracture likelihood in dogs with antebrachial bone neoplasia.

Review of Incidence and Risk Factors for Spinal Fauctures in Canines

A survey was conducted to analyze vertebral fractures in dogs presented to the Madras Veterinary College Orthopaedic Outpatient Unit during a period of one and half year. A total of 24 cases were included, predominantly males with an average weight of 16 to 18 kilograms. The primary causes identified were road traffic accidents (n=15) and high-rise syndrome (n=9), affecting predominantly dogs aged 5 months to 2 years (n=14). Non-descript breeds were most commonly affected. Fractures were most frequently observed in the caudal thoracic vertebrae (T11 to L1). CT myelography revealed ventral displacement in cases of luxation, primarily affecting the thoracolumbar and lumbosacral regions. This study underscores the prevalence and characteristics of vertebral fractures in dogs, highlighting the need for prompt diagnosis and appropriate management strategies.

Virtual surgical planning and use of a 3D-printed, patient-specific reduction system for minimally invasive plate osteosynthesis of diaphyseal tibial fractures in dogs: A historic case control study.

To compare the efficacy and clinical outcomes of computed tomography (CT)-based virtual surgical planning (VSP) and a three-dimensional (3D)-printed, patient-specific reduction system to conventional indirect reduction techniques for diaphyseal tibial fractures stabilized using minimally invasive plate osteosynthesis (MIPO) in dogs. A prospective clinical study with a historic control cohort. Dogs undergoing MIPO stabilization of diaphyseal tibial fractures using a custom 3D-printed reduction system (3D-MIPO; n = 15) or conventional indirect reduction techniques (c-MIPO; n = 14). Dogs were prospectively enrolled to the 3D-MIPO group and CT scans were used to design and fabricate a custom 3D-printed reduction system to facilitate MIPO. Medical records were searched to identify dogs for the c-MIPO group. Pre-, intra- and postoperative parameters were compared between groups. The duration from presentation until surgery was 23 h longer in the 3D-MIPO group (p = .002). Fewer intraoperative fluoroscopic images were acquired (p < .001) and mean surgical duration was 34 min shorter in the 3D-MIPO group (p = .014). Median postoperative tibial length, frontal alignment, and sagittal alignment were within 4 mm, 3° and 3°, respectively, of the contralateral tibia in both groups and did not differ between reduction groups (p > .1). Postoperative complications occurred in 27% and 14% of fractures in the 3D-MIPO and c-MIPO groups, respectively. Both reduction methods yielded comparable results. Although the preoperative planning and guide preparation was time consuming, surgery times were shorter and fluoroscopy use was lessin the 3D-MIPO group. VSP and the custom 3D-printed reduction system facilitated efficient MIPO.

Clinical Assessment of a Lateral Epicondylar Anatomical Plate for the Stabilization of Humeral Condylar Fractures in Dogs.

To report the use of a Lateral Epicondylar Anatomical Plate for the management of humeral condylar fractures (HCF) in dogs. Medical records of dogs with HCF stabilized using the Lateral Epicondylar Anatomical Plate at six UK veterinary referral centres between April 2018 and February 2021 were reviewed. Long-term follow-up (>6 months) was obtained via owner questionnaire, which incorporated the Liverpool Osteoarthritis in Dogs clinical metrology instrument. Sixty-two HCF were treated in 61 dogs (44 lateral condylar fractures [LCF] and 18 intracondylar (T/Y) fractures [ICF]). Fifty-one dogs were Spaniels or Spaniel crossbreeds. Intraoperative contouring of the plate was required for one dog-a French Bulldog. Postoperative complications occurred in 14/42 LCF and 6/18 ICF; overall there were 14 minor, 8 major, and 2 catastrophic complications. On final follow-up imaging, there was evidence of partial or complete osseous continuity of the condylar part of the fracture 32/53 HCF (24/39 LCF and 8/14 ICF) and lateral epicondylar part of the fracture in 53/53 HCF (39/39 LCF and 14/14 ICF). At final reexamination, 20/28 dogs with LCF and 5/13 dogs with ICF were not lame and the remaining dogs demonstrated mild lameness. According to the owner questionnaire, 17/17 dogs with LCF and 8/10 dogs with ICF returned to full limb use and median Liverpool Osteoarthritis in Dogs scores were 2/52 for LCF and 6.5/52 for ICF. The Lateral Epicondylar Anatomical Plate can be used successfully for the surgical stabilization of HCF in dogs.

Evaluation of a 3D-Printed Reduction Guide for Minimally Invasive Plate Osteosynthesis of Short Oblique Radial Diaphyseal Fracture in Dogs: A Cadaveric Study.

This study aims to evaluate the clinical application of three-dimensional (3D)-printed custom reduction guides (3DRG) for minimally invasive plate osteosynthesis (MIPO) of short oblique radial diaphyseal fractures. Canine forelimb specimens (n = 24) were prepared and a diaphyseal short oblique fracture was simulated in the distal radius and ulna. Bone fragments were stabilized with the MIPO technique using a 3DRG (Group A), open reduction (Group B), or closed reduction with circular external skeletal fixation (ESF) (Group C). The diaphyseal short oblique fractures were created in each radius at one-third of the radial length from the distal radial articular surface. Surgical stabilization of the fractures was performed in each group. Pre and postoperative radiographic images were obtained to measure frontal angulation (FA), sagittal angulation (SA), frontal joint reference line angulation (fJRLA), sagittal joint reference line angulation (sJRLA), translational malalignment and fracture gap width. Surgical time was also measured. In the homogeneity test, differences in SA, sJRLA, craniocaudal translation and fracture gap before and after surgery had no significant difference among the three groups. On the other hand, differences in FA, fJRLA, mediolateral translation and surgical time before and after surgery had significant differences among the three groups. In the post hoc test, only surgical time showed a significant difference between the three groups, and group A showed the shortest surgical time. The use of 3DRG for MIPO of short oblique radial diaphyseal fractures in dogs is reliable for the alignment and apposition of fractures and reduces surgical time.

Designing and clinical application of caps for intramedullary pinning to manage long bone fracture in dogs

Study was carried out to design and evaluate clinical application of caps for intramedullary pinning to mange long bone fractures in dogs. Cannulated cancellous caps made of 316 L stainless steel with dimensions of 10 mm × 25 mm (length) cap for 4 mm, 4.5 mm and 5 mm steinmann pin and 8 mm × 25 mm (length) cap for 2.5 mm and 3 mm steinmann pin were designed. A total of 14 cases of dogs presented with simple transverse, short oblique fractures of long bones were equally divided into groups A and B having 7 animals in each. Simple intramedullary pinning was done in group A, whereas, in group B designed caps were fixed at entry point at trochanteric fossa after intramedullary pinning to prevent proximal migration of pins. Posture, gait, perception of pain and lameness scores were assessed during 15, 30 and 60 day, postoperatively. Caps offered rigid fixation along with intramedullary pin resulting in mild or moderate callus formation. Excellent postoperative functional recovery without any pin migration, seroma formation and valgus limb deformity were observed in group B. Results of present preliminary study suggested that designed capped intramedullary pinning offers stable internal fixation and prevented pin migration, sciatic injury and seroma formation.

Comparison of exposure of the radius afforded by the craniomedial and craniolateral open surgical approaches in dog cadavers.

Management of antebrachial fractures in dogs typically involves open reduction and bone plate stabilisation of the radius performed using either a craniomedial approach (CMA) or craniolateral approach (CLA). The aim of this cadaveric study was to compare radial exposure afforded via the craniomedial and craniolateral approaches, without and with releasing the abductor digiti I longus (ADIL) muscle. The CMA and CLA were performed on alternate paired cadaver forelimbs with the subsequent release (CMA) or elevation (CLA) of the ADIL muscle (n = 12). The percent area of exposure was calculated in defined longitudinal radial segments (LRSs) and hemi-circumferential radial segments (HRSs) using digitally uploaded images. A non-parametric rank sum test was used for statistical analysis (p < 0.05). While both the CMA and CLA provided sufficient exposure for radial cranial plate placement in the mid-to-distal diaphyseal region (50-80% LRSs), the CMA afforded greater exposure to the distal metaphysis (80-90% LRS). The CLA was advantageous in exposing the proximal diaphysis (20-50% LRSs) and distal epiphysis (90-100% LRS). Exposure of the distal diaphyseal, metaphyseal, and epiphyseal regions (80-100% LRSs) was impeded by the ADIL muscle. A tenotomy of the tendon of insertion of the ADIL muscle increased exposure afforded by the CMA in the distal metaphyseal and epiphyseal regions. The exposure afforded by the CLA in the distal diaphyseal and metaphyseal regions was significantly improved by elevating the origin of the ADIL muscle. The results of this study provide useful clinical information when surgeons are deciding which approach to use for cranial radial plating.

Sacral fracture stabilisation using dorsal transiliac locking plates: 12 cases (2017-2023).

To describe the clinical presentations, outcomes and complications associated with the use of dorsal transiliac locking plates to stabilise sacral fractures in dogs and cats. A single-centre retrospective analysis of all patients that presented with sacral fractures between February 2017 and February 2023 that were managed surgically using paired dorsal transiliac locking plates. Twelve animals met the criteria for inclusion in a retrospective clinical case series. An owner questionnaire was employed to assess long-term outcomes. Eleven dogs and one cat with a mean age of 3.1 years (range 0.6 to 8.8) were included. Eleven patients presented following a motor vehicle accident and most were either non-ambulatory (n=8) or displayed severe unilateral hindlimb lameness (n=4). Nine sacral fractures were considered Anderson type II and three Anderson type V. The plate fixation was augmented with additional surgical stabilisation in 11 cases. Eleven patients were ambulatory at discharge and all cases healed uneventfully without major surgical or postoperative complications. Long-term follow-up (>60 days) was available in 10 animals at a mean of 694 days (range 65 to 1805) and owner-assessed outcomes via questionnaire were reported as good to excellent in all cases. The application of transiliac locking plates provided sufficient stability to facilitate sacral fracture healing with minimal clinical complications. This method represents a robust and safe option to stabilise sacral fractures in dogs and cats, offering an alternative to iliosacral lag screw fixation.

Clinical Application and Evaluation of Specialised Ring Fixators for the Management of Upper and Lower Limb Bone Fractures in Dogs

Present study was conducted on nine-clinical cases of humerus (n=4), femur (n=3) and radius-ulna (n=2) fractures in dogs of either sex, weighing 5.5 to 18 kg. Both closed (n=6) and open (n=3) fractures were treated in this study. The fracture was reduced and stabilized by transfixation using modified ring fixators. Semicircular (n=4) and hybrid fixators (n=5) were used for upper limb and lower limb bones respectively. The main component of fixator i.e. aluminium rings were designed locally at Bikaner using 4-mm aluminium sheets and fabricated accordingly. Full rings were used for distal radial (n=2) and distal femoral (n=1) fractures whereas semicircular rings were made through cutting the full ring during surgery for specific humeral (n=4) and femoral (n=2) fractures. Specialised wire fixation bolt (iron based; weighing 5.5g) was also designed locally at Bikaner for transcortical pin and ring articulation. Humeral and distal femoral fractures are challenging while bone plating of distal radial fracture demands further surgeries therefore external fixators were modified and applied in present study. Operated limbs were evaluated clinically with serial postoperative radiographs at regular intervals. Fixator-assembly evaluation and functional recovery of operated limbs were considered as objectives of this study.

Three-dimensional models of physeal fractures in the femur for the teaching of veterinary medicine.

To develop and assess three-dimensional models of physeal fractures in dog femurs (3D MPFDF) using radiographic imaging. The study was conducted in three phases: development of 3D MPFDF; radiographic examination of the 3D MPFDF; and comparative analysis of the anatomical and radiographic features of the 3D MPFDF. The base model and the 3D MPFDF achieved high fidelity in replicating the bone structures, accurately maintaining the morphological characteristics and dimensions such as length, width, and thickness, closely resembling natural bone. The radiographs of the 3D MPFDF displayed distinct radiopaque and radiolucent areas, enabling clear visualization of the various anatomical structures of the femur. However, in these radiographs, it was challenging to distinguish between the cortical and medullary regions due to the use of 99% internal padding in the printing process. Despite this limitation, the radiographs successfully demonstrated the representation of the Salter-Harris classification. This paper presents a pioneering project focused on technological advancement aimed at developing a method for the rapid and cost-effective production of three-printed models and radiographs of physeal fractures in dogs.

Встречаемость переломов в области грудной и тазовой конечностей у собак

Currently, there is a trend towards popularization of pet dogs in the city of Moscow. Despite the rapid development of science and technology in veterinary medicine, limb fractures are still one of the most common pathologies. In this article, a retrospective analysis of the prevalence of fractures in dogs in the thoracic and pelvic limbs was performed, the age and breed groups of dogs most prone to fractures were determined, and the most traumatized limb regions were identified. The most common types of fractures were also established. Based on the results, it can be concluded that the forearm bones of small breeds of dogs with body weight up to 10kg are most susceptible to fractures in the thoracic limb. In the pelvic limb, tibia fractures were more common in medium breed dogs with body weight from 10 kg to 25 kg. Simple oblique bone fractures were more frequently registered in dogs in the studied groups.

A retrospective study on the incidence of long bone fractures in dogs

A retrospective study on the incidence of long bone fractures in dogs

Surgical management of femoral neck fracture in dog with trans-articular pinning: A case report

Surgical management of femoral neck fracture in dog with trans-articular pinning: A case report

APPLICATION OF VOSYS-OPTIMA SYSTEM COMPONENTS IN CONSTRUCTION OF HARDWARE LAYOUTS OF MONOLATERAL COMBINATION WITH ANGULAR SUPPORT IN CASES OF TREATMENT OF INTRAARTICULAR KNEE FRACTURES AND DISTAL CIRCUMARTICULAR FRACTURES OF THE FEMUR IN DOGS AND CATS

For treatment of prearticular and intraarticular fractures including knee joint area in dogs and cats, as a rule, thin pins, serclage, plates, and their combinations are used depending on fracture area and fracture complexity, which fails to fully provide sufficient stability of osteosynthesis.&#x0D; Purpose of the study was to study the processes taking place in the joints of operated animals at prolonged blockage with hardware constructions for the period of healing of the prearticular and intraarticular fractures.&#x0D; Scientific novelty. Based on a comprehensive study, the use of monolateral combination arrangements with angular support for the treatment of intra-articular fractures of the stifle joint, as well as distal periarticular femur fractures in dogs and cats, was evaluated. The feasibility of the need to protect the operated area from force during fracture healing was determined.&#x0D; Methods. To treat fractures in the knee joint area, polyfunctional monoblocks without a push-back rod, transosseous insertion rods of different diameters depending on the size of the animal, and supports of different diameters with a 125-130° bend were used.&#x0D; A total of 16 operations were performed, 5 dogs and 11 cats. The dogs came in weighing from 4 to 15 kg. The age was from 5 to 38 months old. The cats were 4 to 41 months old, their weights ranging from 1.2 to 5 kg. The supports used were 3, 4, and 5 mm in diameter.&#x0D; Results. Contracture of the operated limbs in the animals after removal of the hardware constructs in our study was more or less pronounced in the animals with more than 2 weeks of hardware fixation. We did not find the presence of contracture in animals with hardware structures removed after two weeks, while lameness in these animals could be observed from 3 to 12 days, the loss of muscle mass of the thigh in the form of a decrease in its volume was not observed. The picture was similar for both cats and dogs.&#x0D; Conclusion. The use of monolateral combinations with angular support for treatment of intraarticular fractures of the knee joint as well as distal circumarticular fractures of the femur in dogs and cats is reasonable in terms of the need to protect the operated area from forceful influences during fracture healing.&#x0D; The most physiological period of blocking the area of the knee joint with the external fixation apparatus in our study was from 2 to 3 weeks regardless of the age of the animal.

Long-term outcomes of atrophic/oligotrophic non-unions in dogs and cats treated with autologous iliac corticocancellous bone graft and circular external skeletal fixation: 19 cases (2014-2021).

To determine the short- and long-term outcomes and complications in dogs and cats undergoing surgical treatment for viable oligotrophic and nonviable atrophic non-unions using circular external skeletal fixation and autologous corticocancellous bone graft. In this case series, the medical records and radiographs of all dogs and cats with radius/ulna and tibia/fibula viable oligotrophic and nonviable atrophic non-unions treated with corticocancellous bone graft and circular external skeletal fixation at two referral veterinary hospitals between 2014 and 2021 were retrospectively reviewed. The long-term follow-up was 1 year or greater. Thirteen dogs and six cats with 19 non-union fractures met the inclusion criteria for the study. Eighteen non-union fractures (94.7%) healed and one did not. Five patients (26%) had minor perioperative period complications (<3 months). The patient that did not achieve bone union underwent revision surgery with internal fixation (plate and screws) and autologous cancellous bone graft. Fifteen (78.9%) cases returned to full function and three (15.8%) cases returned to acceptable function in the long-term follow-up period. The use of circular external skeletal fixation associated with autologous corticocancellous bone graft for the treatment of radius/ulna and tibia/fibula atrophic/oligotrophic non-union fractures in dogs and cats was considered successful in the majority of patients and was free of major or catastrophic complications.

External Fixation for Fracture Stabilization of the Sacrum in 15 Dogs.

This study aimed to evaluate the feasibility, complications, and outcomes of external fixation (EF) for the treatment of sacral fractures in dogs, either as a primary fixation system or as a complementary technique. A total of 15 dogs with sacral fractures were surgically treated using different EF configurations, either as primary or secondary stabilization. The results were evaluated for the extent of fracture reduction, stability during treatment, complications, and bone healing. In most cases, the outcomes were excellent in terms of bone healing, neurological conditions, and pain assessment. The mean bone healing time was 9.45 ± 5.66 weeks. One (6.66%) patient presented a complication due to the technique. In conclusion, the use of EF should be considered for the stabilization of sacral fractures because of its minimal invasiveness, stability, and ease of application.

Use of supracutaneous bone plating for management of radius/ulna and tibia/fibula fractures in dogs

The study was done with the objective to utilize supracutaneous bone plating as a mean of minimally invasive osteosynthesis for management of radius/ulna and tibia/fibula fractures in dogs. Nine cases of long bone fracture (2 radius/ulna and 7 tibia/fibula fracture) in dogs having body weight 8-20 kg and age 4 months to 2 years were repaired with supracutaneous bone plating (minimally invasive plate osteosynthesis) under general anaesthesia after a thorough physical, orthopaedic, neurological and radiographic examinations. Intra-operatively, 3.5 mm, locking head-limited contact-dynamic compression plate (LH-LC-DCP) was used in locking mode with insertion of two self-tapping locking head cortical screws of 3.5 mm (of varying length) in each proximal as well as distal fracture. The bone plate was applied on the medial surface of radius and tibia. Postoperative radiographs were taken to assessthe status of fracture reduction and fixation which was good in all the cases. Regular follow-ups showed good fracture reduction as well as fixation with no changes in implant position. Loosening of screws was observed in single case with no other complication in any of the cases. All the implants were removed on or before 68th day after surgery under sedation. All the animals showed good weight bearing with near to normal limb function on final day of the reappraisal. The supracutaneous bone constructs provided good reduction and fixation at fracture site similar as external skeletal fixators not compromising on axial and torsional stiffness.

Dynamics of acute-phase and endothelial reactions and immune complex formation during bone replacement with germanium-doped calcium-phosphate ceramics of bone fragment fractures in dogs

Bone defects that occur with fragment fractures lead to an increase in the number of postoperative complications. Therefore, to restore the structure and function of the bone, there is a need for bone replacement, in particular doped calcium-phosphate ceramics. The purpose of the work is the biochemical assessment of acute-phase and endothelial reactions and immune complex formation during bone replacement with germanium-doped calcium-phosphate ceramics of bone fragment fractures in dogs. Dogs with fragment fractures of long tubular bones and plate osteosynthesis were included in the study. In the experimental group (n = 10), bone defects were replaced with germanium-doped calcium-phosphate ceramics (HА/β-TCP/l-Gе-700), in the control group (n = 10) – unalloyed (HА/β-TCP-700). Blood samples were taken after the injury and on the 3rd, 7th, 14th, 30th, and 60th days after osteosynthesis. Partial recovery of limb function in the experimental group was faster by 1.3 times (P &lt; 0.001) and full by 1.2 times (P &lt; 0.01) compared to the control. On the 60th day, in experimental animals, the defect was filled with a regenerate of high X-ray density without a periosteal reaction, while in the control animals, the bone regenerate did not have sufficient density with a significant periosteal reaction. In both groups, total protein and albumin content varied within the normal range. The activity of protein C on the 3rd day in the experimental group was 1.3 times higher (Р ˂ 0.001), and on the 7th day, it was twice as high (P ˂ 0.001) compared to the control group with normalization by the 14th day. The concentration of ceruloplasmin from the 7th day in the control animals was 1.1 times higher (Р ˂ 0.001) than in the experimental animals, with normalization in the latter by the 60th day. The level of small molecular circulating immune complexes (CIC) after the injury increased by 1.1 times (Р ˂ 0.001) and reached a peak in the control and experimental groups on the 14th day, with an increase in indicators by 2.1 and 1.4 times (Р ˂ 0.001), respectively, with normalization in the experimental group on the 60th day. The level of nitric oxide (NO) in the control group increased from the 7th to the 60th day, with a peak on the 30th day, and in the experimental group – from the 3rd to the 30th, with a peak on the seventh day. Osteoreplacement of fragment fractures of long tubular bones in dogs with calcium-phosphate ceramics doped with germanium is accompanied by a moderate level of the acute phase reaction and immune complex formation, an increase in the endothelial reaction and the anticoagulant potential of the blood, which contributes to a decrease in the intensity of the inflammatory-resorptive stage of reparative osteogenesis and an increase in its proliferative phase, which, respectively, accelerates the consolidation of fractures.