Polyamide 6 (PA6) films with significant α relaxation process was selected as the model system. The creep behavior and rheological mechanism during deformation in the amorphous regions of semi-crystalline polymers are systematically investigated by carrying out creep experiments. Based on the quasi point defect (QPD) theory, the complete physical process of PA6 film creep behavior from elasticity to viscoelasticity and viscoplasticity was analyzed and modeled from the perspective of structural heterogeneity. The results demonstrate that the creep deformation of PA6 film is a typical thermo-mechanical coupling and nonlinear mechanics process, and potential creep mechanisms corresponds to stress-induced local shear deformation enhancement and thermal activation-induced particle flow diffusion. The elastic-plastic transition involved in the creep deformation process of semi-crystalline polymer originates from the activation of quasi-point defective sites in the amorphous region, the expansion of sheared micro-domains and irreversible fusion. The generalized fractional Kelvin (GFK) model is proposed, and the physical meaning of parameters is explained by combining the quasi point defect theory and creep delay spectrum(L(τ)). Finally, the effectiveness of the GFK model and the QPD theory in studying the deformation behavior of PA6 films was validated by comparing experimental data with theoretical results, which theoretically reveals the structural evolution of PA6 film during creep process.