Abstract In this paper we are concerned with the existence of infinitely-many solutions for fractional Hamiltonian systems of the form t D ∞ α ( - ∞ D t α u ( t ) ) + L ( t ) u ( t ) = ∇ W ( t , u ( t ) ) ${\,}_tD^{\alpha }_{\infty }(_{-\infty }D^{\alpha }_{t}u(t))+L(t)u(t)=\nabla W(t,u(t))$ , where α ∈ ( 1 2 , 1 ) ${\alpha \in (\frac{1}{2},1)}$ , t ∈ ℝ ${t\in \mathbb {R}}$ , u ∈ ℝ n ${u\in \mathbb {R}^n}$ , L ∈ C ( ℝ , ℝ n 2 ) ${L\in C(\mathbb {R},\mathbb {R}^{n^2})}$ is a symmetric and positive definite matrix for all t ∈ ℝ ${t\in \mathbb {R}}$ , W ∈ C 1 ( ℝ × ℝ n , ℝ ) ${W\in C^1(\mathbb {R}\times \mathbb {R}^n,\mathbb {R})}$ and ∇ W ( t , u ) ${\nabla W(t,u)}$ is the gradient of W ( t , u ) ${W(t,u)}$ at u. The novelty of this paper is that, assuming L(t) is bounded in the sense that there are constants 0 < τ 1 < τ 2 < ∞ ${0&lt;\tau _1&lt;\tau _2&lt; \infty }$ such that τ 1 | u | 2 ≤ ( L ( t ) u , u ) ≤ τ 2 | u | 2 ${\tau _1 |u|^2\le (L(t)u,u)\le \tau _2 |u|^2}$ for all ( t , u ) ∈ ℝ × ℝ n ${(t,u)\in \mathbb {R}\times \mathbb {R}^n}$ and W ( t , u ) ${W(t,u)}$ is of the form ( a ( t ) / ( p + 1 ) ) | u | p + 1 ${({a(t)}/({p+1}))|u|^{p+1}}$ such that a ∈ L ∞ ( ℝ , ℝ ) ${a\in L^{\infty }(\mathbb {R},\mathbb {R})}$ can change its sign and 0 < p < 1 ${0&lt;p&lt;1}$ is a constant, we show that the above fractional Hamiltonian systems possess infinitely-many solutions. The proof is based on the symmetric mountain pass theorem. Recent results in the literature are generalized and significantly improved.