Background. By 2040, the number of people with age-related macular degeneration (AMD) is expected to be around 300 million worldwide and 642 million people with diabetes. It will cause a major socioeconomic public health challenge. The main criterion for the anti-VEGF treatment of is the activity of neovascularization, which is determined by its configuration. The search for optimal criteria for quantifying the state of the macular region in order to decide on the appointment of anti-VEGF therapy continues. Purpose. Improving the efficiency of diagnosis and treatment of AMD and diabetic angioretinopathy (DARP) based on the assessment of the configuration of vascular system on the “Key to Diagnosis II” platform. Material and methods. The study included 341 patients: 64 % (218 patients; 267 eyes) non-neovascular AMD, 36 % (123 patients; 174 eyes) neovascular. 56 patients (58 eyes) had active CNV type I. Group 1A – active CNV before treatment (9 patients, 9 eyes), group 1B – non-active CNV after treatment with anti-VEGF (9 patients, 9 eyes), control of 10 patients (10 eyes) without AMD. Analysis of OCT-angio images included the isolation of CNV, its area, fractal dimension (Df) and the complexity of the vascular system (CVS) counting. Results. Group 1A Df 1.5871 ± 0.05, CCC 2.29 ± 0.29, area 11734 ± 4866, 1B – Df 1.6462 ± 0.08, CCC 1.65 ± 0.18, area 6797 ± 3818, control Df 1.9167 ± 0.06, CVS 1, area 0. Significant differences were found for CVS (p= 0.0003). Df correlates with the CNV area (p= 0.7) and is probably an unreliable parameter due to incomplete visualization of active CNVs. In DARP an average correlation was found between stage and Df (p= 0.6) and Df and CCC (p= 0.54), and a high correlation between stage and CVS (p= 0.96). Conclusions. CVS is a universal criterion suitable for evaluation of OCT-angio images for neovascularization activity check for convolutional neural networks training based on the Key to Diagnosis II platform. Keywords: age-related macular degeneration, diabetic angioretinopathy macular neovascularization, antiVEGF, retinal vascular analysis.