In response to the COVID-19 pandemic and its strain on healthcare resources, this study presents a comprehensive review of various techniques that can be used to integrate image compression techniques and statistical texture analysis to optimize the storage of Digital Imaging and Communications in Medicine (DICOM) files. In evaluating four predominant image compression algorithms, i.e., discrete cosine transform (DCT), discrete wavelet transform (DWT), the fractal compression algorithm (FCA), and the vector quantization algorithm (VQA), this study focuses on their ability to compress data while preserving essential texture features such as contrast, correlation, angular second moment (ASM), and inverse difference moment (IDM). A pivotal observation concerns the direction-independent Grey Level Co-occurrence Matrix (GLCM) in DICOM analysis, which reveals intriguing variations between two intermediate scans measured with texture characteristics. Performance-wise, the DCT, DWT, FCA, and VQA algorithms achieved minimum compression ratios (CRs) of 27.87, 37.91, 33.26, and 27.39, respectively, with maximum CRs at 34.48, 68.96, 60.60, and 38.74. This study also undertook a statistical analysis of distinct CT chest scans from COVID-19 patients, highlighting evolving texture patterns. Finally, this work underscores the potential of coupling image compression and texture feature quantification for monitoring changes related to human chest conditions, offering a promising avenue for efficient storage and diagnostic assessment of critical medical imaging.