The main aim of this numerical analysis is to demonstrate the effect of Lorentz force and viscous dissipation on the couple stress-squeezed hybrid-nanofluid flow between two parallel plates under the influence of external squeezing. A novel entropy generation effect is also included to describe the temperature distribution in the couple stress hybrid nanofluid regime. However, the couple stress hybrid nanofluid finds its abundant applications in the various fields of medicine and bio-engineering, particularly, in the removal of obstacles in the arteries, cancer treatment, etc. Inspired by these applications of couple stress hybrid nanofluids, the present problem is devised based on the squeezed parallel plate geometry. The unsteady nonlinear, coupled, two-dimensional, partial differential equations are constructed to disclose the flow and heat transport features. A robust Matlab-based Runge–Kutta fourth-order scheme with shooting technique is used to produce the similarity solutions of the governing equations through the deployment of suitable scaling transformations. Accordingly, it is noted that, enhancing Hartmann and Brinkman numbers increase the entropy generation. Increasing couple stress fluid parameter increases the thermal distribution. Velocity profile shows dual behavior for the raising couple stress fluid parameter. Bejan number increases with increasing Brinkman number. Entropy generation increases with enhancing nanofluid volume fraction. Conclusively, the uniqueness and novelty of the present investigation is the addition of magnetic Ohmic heating and viscous dissipation effects which generalizes the former studies and gives a more redefined numerical simulation of flow and heat transport features of couple stress hybrid nanofluid in the squeezing regime.