The JT-60SA device offers unique conditions before ITER for the study of the interaction of energetic particles with plasma waves. With similar dimensions to JET, e.g., a major radius but with a slightly more elongated plasma volume, JT-60SA is used as a high-power device where additional heating power (including 10 MW of the 500 keV Neutral Beam Injection) of up to 41 MW and the potential for high non-inductive plasma current operation pave the path for numerous challenges in physics on MHD stability, in particular, when considering the effects of energetic particles. Several operational scenarios with ITER and DEMO-relevant plasma regimes, in terms of non-dimensional plasma parameters, are anticipated. In this work, the stability of Alfvén eigenmodes (AEs) in variants of two of the most relevant operational scenarios with single null is analyzed: a full Ip inductive scenario at high density (1.1 × 1020 m−3 on-axis electron density) and 5.48MA/2.05T toroidal plasma current and magnetic field, and an advanced (hybrid) scenario with an ion energy transport barrier (ITB) and 3.5MA/2.28T toroidal plasma current and magnetic field. The workflow included the CRONOS code to establish the scenario, the ASCOT code to calculate the slowing-down energetic particle distributions for a positive/negative ion source-based neutral beam, and the MISHKA/CASTOR-K suite to calculate the MHD spectra of AEs and the associated drive/damping contributions from the NBI energetic ions, as well as the thermal ion landau damping. The systematic analysis, over a large Fourier space of the toroidal mode number/mode frequency, provides evidence that although a significant fraction of supra-Alfvénic particles stemming from the negative ion source-based neutral beam (500 keV) can, in some cases, drive to AEs in both scenarios, it is not enough to overcome the thermal ion landau damping. In addition, the advanced scenario with ITB is shown to be stable against AEs localized in the vicinity of the barrier as well, offering good prospects of sustainability of the plasma performance and of ITB. Finally, some sensitivity scan results are shown on the influence of fast ion density and q-profile on the AE mode spectra and stability.