The entanglement distribution network connects remote users by sharing entanglement resources, which is essential for realizing quantum internet. We propose a photonic-reconfigurable entanglement distribution network (PR-EDN) based on a silicon quantum photonic chip. The entanglement resources are generated by a quantum light source array based on spontaneous four-wave mixing in silicon waveguides and distributed to different users through time-reversed Hong–Ou–Mandel interference by on-chip Mach–Zehnder interferometers with thermo-optic phase shifters (TOPSs). A chip sample is designed and fabricated, supporting a PR-EDN with 3 subnets and 24 users. The network topology of the PR-EDN could be reconfigured in three network states by controlling the quantum interference through the TOPSs, which is demonstrated experimentally. Furthermore, a reconfigurable entanglement-based quantum key distribution network is realized as an application of the PR-EDN. The reconfigurable network topology makes the PR-EDN suitable for future quantum networks requiring complicated network control and management. Moreover, it is also shown that silicon quantum photonic chips have great potential for large-scale PR-EDN, thanks to their capacities for generating and manipulating plenty of entanglement resources.