National Foundation Research Articles

“Memes as the Gusle of the 21st Century”: An Analysis of Memes About Gusle, Gusle Players and Gusle Practices on the Internet

Memes are nowadays both a simple digital form and one of the most prevalent, widely shared contents in the field of creative freedom and digital culture, observed in this case as part of the so-called “Cyber Folk Art”. This paper aims to analyze Internet memes about the gusle (one-stringed instrument) and gusle players, primarily found on social networks such as Instagram and Facebook or obtained via Google searches. Based on the collected (internet) sources and materials, different levels of identification, symbolism, communication and stereotypes, which already emerge as the first associations with gusle practices, can be discerned. The cultural and social contexts will be included in the analysis and interpretation of memes, i.e. comprehensive performances and depictions of ethnic, national, musical and personal foundations of certain historical and public figures from the political and gusle music world will be interpreted through memes – a combination of image, text, and/or videos. As is the case with other genres of Internet memes and musical genres and styles, the creation of content based on social needs, the writing of social space into musical space and vice versa, as well as the mapping of a symbolic space and stereotypes are evident in the presented and analyzed memes. It can be said that memes about gusle and gusle players, i.e. gusle practices, represent a kind of simplified form of communication in terms of the use of stereotypes and symbolism that indicate different levels of identification, which is the topic with potential for further and more detailed research.

Multiscalar and in/formal: Infrastructuring refugee arrival in disempowered cities

<p>This paper explores how refugee arrival is infrastructured in declining cities in the US, France, and Germany, examining whether urban shrinkage affects local practices. In doing so, it reveals how refugee arrival is infrastructured across scales and by a bricolage of actors operating on a spectrum of in/formality. Due to long-term decline and limited municipal budgets, local non-governmental actors, including refugees themselves, have been found to play important roles alongside regional and national foundations in shaping arrival in cities. While a great deal of arrival infrastructuring takes place locally, the municipalities themselves were found to be notably absent. While bottom-up action was found to have considerable impact through various interventions, its influence is constrained as the institutionalization of local action is contingent upon funding from external entities such as foundations. The paper introduces the concept of multiscalar arrival infrastructuring to showcase the complex actor constellations and raises questions about power imbalances and competing interests among actors shaping arrival infrastructures for newcomers in downscaled and disempowered places.</p>

Religion in political power: a philosophical study on the role of religion in the 2019 elections

In the sixteenth century, European countries were divided due to conflicts between Catholics and Protestants regarding which religion should govern. The conflict between them ultimately concluded not by granting special rights to a particular religion, but rather by separating the church from the state and strengthening the freedom of religion for everyone. This decision had the consequence of enhancing cross-border human solidarity beyond the barriers of religion, culture, economy, race, gender, and various other divides. The history of Indonesia is marked by dynamics somewhat similar, especially when examining efforts to find the philosophical foundation of the Indonesian nation. The inner atmosphere during the session of the Investigating Body for Preparatory Work for Independence/Preparatory Committee for Indonesian Independence (BPUPK/PPKI) reflects well how the strong and argumentative discourse of the founding fathers led to the agreement to choose Pancasila as the shared philosophy. The founding fathers chose an ideal path for Indonesia by making Pancasila the philosophy, ideology, and foundation of the Indonesian state. Pancasila became the noble covenant of this nation, where within it, all diversity (pluralism) and heterogeneity of this nation are united but not standardized. Religion is one of the diversities and diversities of the Indonesian nation. There are six religions and various belief systems that coexist in Indonesia. In the 2019 general elections, the colors of support left certain traces that are worth reflecting on. From the vote counts of the General Election Commission, this support factor is visibly apparent. Provinces like Aceh and Bali, for example, can serve as references to observe these patterns of support. This is certainly something legitimate in the realm of democracy. However, when we look at various news and sentiments that emerged during the campaign, it is clear that religion was dragged into this practical political arena. This undoubtedly becomes an important reflection for the Indonesian nation in facing the dynamics of religious intertwining with politics.

Князь Серебряный и князь Мышкин: образ «положительно прекрасного» героя у А. К. Толстого и Ф. М. Достоевского

The article offers a study of the images of Prince Nikita Serebryany in the historical work of the same name by A. K. Tolstoy and Prince Lev Myshkin in the novel by F. M. Dostoevsky «The Idiot» in light of the concept of a «positively beautiful» person. It is noted how important and how difficult it was for both writers to create an extraordinary image of a hero who is sharply different from those around them and at the same time captivates the hearts of other characters and the reading audience. The main characteristics of the central characters in the novels are traits inherent in a Christian personality: sincerity, straightforwardness, a childishly open heart, the absence of selfish aspirations that are perceived in society as stupidity; patriotism and devotion to Orthodoxy as the spiritual foundation of the Russian nation. The images of Serebryany and Myshkin are united by their key motives of foolishness and self-sacrifice, which symbolize their special mission – to serve as moral guidelines for a society that has lost its ideals; become a seed from which goodness and truth can sprout in future generations. Numerous echoes and connections in the plot and figurative structure of the works under study have been identified, which allows us to conclude that when creating the image of Prince Myshkin, Dostoevsky used not only the experience of European classics (Cervantes, Dickens, Hugo), but was also inspired by the artistic example of his compatriot, A. K. Tolstoy.

CONCEPTUAL BASIS OF POLITICAL MODERNIZATION AS AN IMPORTANT FACTOR OF SOCIAL AND SPIRITUAL DEVELOPMENT

In this article, the conceptual basis of political modernization is emphasized, which is an important factor in social-spiritual development, the creation of conditions for sociocultural growth in a new stage of state development, Strengthening democracy and economic competitiveness, ensuring prosperity and national foundations that are the basis of spiritual growth, transition to national modernization in accordance with the principle of «human dignity» based on legal norms. Theoretical foundations are shown.

Dr. Thomas Francis Jr.: A Legacy of Vaccine Innovation and Public Health Advancement.

Dr. Thomas Francis Jr. was an American physician, virologist, and epidemiologist who was a professor of epidemiology at the University of Michigan from 1941 to 1969. He focused on studying infectious diseases, particularly pneumonia, influenza, and poliomyelitis, and developing vaccines and clinical trials. He earned his medical degree from Yale University in 1925. In 1941, the Armed Forces Epidemiological Board (AFEB) appointed him as the Director of the Commission on Influenza. This prestigious role underscored his expertise and leadership in combating infectious diseases and successfully developing field trials and evaluations of protective influenza vaccines. In 1954, he spearheaded the largest and most comprehensive clinical trial of the Salk polio vaccine at the University of Michigan Vaccine Evaluation Center, with vital support from the National Foundation for Infantile Paralysis (NFIP). He received the Medal of Freedom in 1946, the Lasker Award in 1947, and the Medal in Global Public Health in 2005.

(Invited) Revealing the Reaction Mechanism and Chemo-Mechanics of Solid-State Na-S Batteries

Solid-state sodium-sulfur batteries show great promise for energy storage applications due to their high energy density, cost-effectiveness, and abundance of raw materials. Despite these promising characteristics, challenges such as the phase evolution of (poly)sulfides and how it is linked to the significant volume expansion occurring in the cathode during cycling are still poorly understood.1,2 In this talk, I will showcase our recent progress in developing solid-state sodium-sulfur batteries using different solid electrolyte systems, namely Na3PS4 and closo-borates. I will discuss how tortuosity impacts sulfur utilization in the composite cathode and provide new insights into sulfur redox chemistry and associated kinetic limitations. Furthermore, I will examine the correlation between phase, volume, and stress evolution.In summary, this study will offer unprecedented insights into the underlying mechanisms in solid-state sodium-sulfur batteries, which are of utmost importance for their further development towards commercialization. References Lei, Y. J., Liu, H. W., Yang, Z., Zhao, L. F., Lai, W. H., Chen, M., ... & Wang, Y. X. (2023). A Review on the Status and Challenges of Cathodes in Room‐Temperature Na‐S Batteries. Advanced Functional Materials, 33(11), 2212600.Ma, J., Wang, M., Zhang, H., Shang, Z., Fu, L., Zhang, W., ... & Lu, K. (2023). Toward the Advanced Next‐Generation Solid‐State Na‐S Batteries: Progress and Prospects. Advanced Functional Materials, 33(20), 2214430. Acknowledgment D.R. acknowledge financial support from the Austrian Federal Ministry for Digital and Economic Affairs, the National Foundation for Research, Technology, and Development, and the Christian Doppler Research Association (Christian Doppler Laboratory for Solid-State Batteries). J.T., J.K., D.R. acknowledge funding from the European Union's Horizon Europe research and innovation program under Grant Agreement No 101103834 (OPERA).

Health-related quality of life profiles of adults with arthritis and/or fibromyalgia: a cross-sectional study.

Adults with arthritis experience poor health-related quality of life (HRQOL), though research often focuses on single HRQOL outcomes or summary scores. We aimed to identify HRQOL profiles in adults with different arthritis types and determine risk and protective factors. Data including PROMIS-29 Profile v2.1 and PROMIS Short Form v2.0 - Emotional Support 4a were collected through a national foundation's online survey of adults with arthritis in the U.S. We used latent profile analysis (LPA) to characterize the heterogeneity in arthritis patients by clustering them into HRQOL profiles, based on statistical model fit and clinical interpretability. We fit a multinomial logistic regression model with HRQOL profile assignment as the outcome to determine associations with protective and risk factors. We included 25,305 adults with arthritis. The LPA results favored a five-HRQOL profile solution (entropy = 0.83). While some profiles displayed better HRQOL in some domains, 93% of the sample displayed impacted pain and physical functioning. One profile (20%) displayed mean T-scores nearly 2 standard deviations below the population mean. Despite poor physical HRQOL outcomes, one profile (10%) displayed average mental health. All demographic and clinical factors contributed significantly to the model, including risk factors (arthritis types, work status) and protective factors (more emotional support, starting exercise). We identified profiles with consistently impacted HRQOL in arthritis, though one displayed average mental health functioning despite poor physical functioning. These results highlight the value of considering the patient's HRQOL experience alongside treatment options, and the potentially positive impact of non-pharmacological interventions.

The Actualization of Civic Education as a Solid Foundation for Youth in Countering Secularism

Civic Education holds significant importance as a scientific field in cultivating the moral values of the Indonesian population and shaping the future image of the country. In the present era, there is an urgent need for Civic Education among the Indonesian people, particularly the youth, to establish a solid national foundation and develop noble character traits that will protect them from the influence of secularism pervading society. Secularism is viewed as a formidable adversary to the Indonesian people, and it is crucial to prevent the younger generation from embracing such ideas within the boundaries of the Indonesian state. This article adopts a literature review approach, incorporating articles from various credible sources such as SAGE Journal, Google Scholar, and relevant books, in order to enhance the credibility and accuracy of the research findings. The outcomes of this study will comprehensively illustrate the implementation of Civic Education as a means to empower youth in firmly opposing the spread of secularism in Indonesia. The role of youth in shaping the nation's civilization is of utmost significance, as they serve as the vanguard in safeguarding against the encroachment of secularism and strive towards realizing the national ideals of independence, unity, sovereignty, justice, and prosperity

Settler militarism: Affective colonial pursuits and the militarized atmosphere of war commemoration

This article examines settler militarism and how it is mobilized through affective practices that ultimately bolster the settler colonial project. With this intent, it develops the concept of ‘militarized atmosphere’ defined as a staged environment where war is positioned outside politics and critical scrutiny through a series of affective manoeuvres and aesthetics. A militarized atmosphere operates through military aesthetics to attune people’s bodies to a position of uncritical validation of a given discourse of war. This article argues that a militarized atmosphere crucially sustains the settler colonial project by removing or reducing contestation around the theme of war, which is a pillar of settler colonialism. In settler societies, numerous Indigenous individuals perceive themselves as embattled and seek acknowledgement of the history and legacy of colonial violence and warfare. In contrast, settler governments have a vested interest in concealing this history and its enduring legacy, and they do so by exalting military warfare as the foundation of the modern nation and creating affective attachments to the military. The article uses the case of Australia to elucidate the argument. It examines how the aesthetics of war commemoration at the Dawn Service, Australia’s major commemorative event, contributes to producing a militarized atmosphere that sustains the Australian settler colonial project. It proposes a framework that links the feminist concept of affective militarism to settler colonialism and contributes to the emerging literature on settler colonialism and militarism.

Kim Bok-jin - the founder of national sculpture in Korea during the Japanese colonial period

This study analyzes the biography and work of Kim Bok-jin (pseudonym: Chongwan), the first Korean to graduate from the sculpture department of Tokyo University of the Arts in Japan during the Japanese colonial period (in 1925) and the first sculptor to introduce Western realist techniques to Korea. The study will also examine the national motifs in the works of Kim Bok-jin against the backdrop of a difficult historical period, and analyze a number of his little-known works through the prism of Korean studies. The main content of the study is the sculptures of Kim Bok-jin “standing woman”, “statue of Maitreya Buddha” “Baek Hwa”, “Youth (Boy)”, “Old man”. He is a significant figure in Korean sculpture: from 1925 until his death in 1940, Kim Bok-jin regularly exhibited his works at the Joseon Art Exhibition, and in addition to his artistic activities, he also ran the Art Research Institute, nurturing young artists. He also engaged in journalism, criticism, and political activity as a member of the Joseon Communist Party. The purpose of this study is to rethink the work of Kim Bok-jin, the founder of Korean sculpture, who was posthumously awarded the Order of Merit of the National Foundation in 1993.

1920년대 대한민국 임시정부 주관 기념행사와 항일노래

This study examined the aspects and historical roles of anti-Japanese songs created and sung during the activities of the Provisional Government of the Republic of Korea in Shanghai, China, which resisted Japanese imperialism’s invasion of Korea. It is intended to clarify the reality and significance of cultural and artistic independent activities by analyzing the types and contents of anti-Japanese songs sung at various commemorative events held by the provisional government. First, the Shanghai Provisional Government celebrated March 1, the day of the declaration of independence, as a national holiday, and August 29 as a national Humiliation day. In addition, October 3 of the lunar calendar was established as “Foundation Day” and commemorative events involving temporary government factors were steadily held. At the site of this anniversary event, various anti-Japanese songs, including “The National Anthem,” were made and sang together to strengthen their will to resist Japanese. Second, the March 1st Independence Day event was held as a “celebration ceremony to commemorate the Declaration of Independence” in which lawmakers, government ministers, and students gathered within the parliamentarians. Participants sang “The National Anthem” based on the tune of “Auld lang Syne,” and mainly sang “Samiljeolga” and “Independence Army Song.” Independence Army Song is a representative Manchurian independence army song that was sung a lot in the 1910s, and the tune is borrowed from the American military song “Marching Through Georgia”. Third, on August 29th, the National Humiliation Day, “National Humiliation Song” and “National Humiliation Memorial Song” were mainly sung. On October 3rd of the lunar calendar, great religious figures and government factors attended the National Foundation Day and mainly sang “Shinga”. Fourth, various forms of memorial songs, including Requiem, were sung at an event to commemorate the martyrs who died during the independence movement. The memorial song was later sung at every event with a tune and was handed down as an anti-Japanese song.

Decoding the apple paradox: a critical discourse analysis of gender, technology, and nationalism in China’s digital space

This research explores the intricate nexus of gender, technology, nationalism, and misogyny within the context of China’s digital realm. Positioned against the backdrop of an internet celebrity’s accusation towards Apple, the study critically examines a uniquely crafted narrative that adds socio-cultural dimensions to Apple’s perceived network misrepresentations. Female iPhone users are strategically criticized as intellectually inferior influencers of societal contributions, reflecting prevalent discussions regarding 5G technology. The narrative further stigmatizes female iPhone users with implications of involvement in sex work, leading to significant brand implications. Rooted in the framework of Feminist Critical Discourse Analysis (FCDA) and assisted with the approach of corpus-assisted critical discourse analysis (CADA), this study deciphers the complex narrative, focusing on themes of cyber misogyny, economic stratification, and nationalism. The research further reveals how this criticism toward female iPhone users extends beyond mere resentment, unveiling deeper foundations of nationalism and threat perceptions toward traditional phallocentric dominance. The term “traitors” allocated to female iPhone users rationalizes the ongoing assaults as patriotic endeavors, bellwethering toxic nationalism that marginalizes minoritized individuals. This scholarly examination underscores social media platforms, with a focus on Douyin, as potent venues for reinforcing gender bias, particularly through their algorithmic recommendations, content moderation practices, and governance models. This delineation emphasizes the critical need for ongoing sociocultural and digital discourse to challenge and mitigate these dominant, biased narratives.

The Pengayaan Literatur dan Implementasi Nilai Pancasila pada Anak Usia Dini di SDN Suci 5 Jember

Introducing Pancasila from an early age is crucial to fostering a sense of love for the homeland, starting with education at the primary school level. This socialization activity was conducted by university students at SDN Suci 5, located in Desa Suci, Kecamatan Panti, Kabupaten Jember, due to many students lacking an understanding of the importance of learning Pancasila. The goal of this socialization is to help students internalize and apply the values of Pancasila in their daily lives, considering that Pancasila is the foundation of Indonesia, a multicultural nation characterized by diverse ethnicities, races, religions, and cultures. This diversity is reflected in Pancasila's motto, "Bhineka Tunggal Ika," which means "Unity in Diversity." As the nation's foundation, Pancasila should guide the behavior of every citizen. Instilling Pancasila values from an early age is expected to strengthen Indonesia's resilience in facing various challenges. Therefore, implementing Pancasila in daily life is essential to showcase a dignified and culturally rich national identity

Vaccination of Adolescents as an Important Way to Preserve Demographic Nation's Potential

Relevance. Currently, adolescents are protected against 8 infections within the framework of the National Vaccination Schedule: tuberculosis, viral hepatitis B, diphtheria, tetanus, measles, rubella, mumps and influenza (annually). Post-vaccination immunity to whooping cough, acquired in the first years of life, begins to decline since 4–7 years. In recent decades, there has been an increase in the incidence, including among adolescents, of such pathogens as Neisseria meningitidis, Streptococcus pneumoniae, Bordetella pertussis, strains of the human papillomavirus (HPV) of high oncogenicity, the herpes zoster virus and etc., that affect the creation of the foundation of future health nation. Aim. To substantiate the vaccination strategy for adolescents as one of the most important factors for creating the demographic security of the nation. Results. The burden of infectious pathologies of meningococcal, pneumococcal etiology, pertussis, HPV and herpes Zoster, its impact on the development of the health of adolescents in Russia and the intended tactics for implementing vaccination of young people with the help of modern immunobiological drugs are shown. Conclusion. Vaccination of adolescents against infections such as meningococcal and pneumococcal infections, whooping cough, chicken pox, and HPV is a strategic task, since reducing the risk of contracting infectious diseases in this age group directly affects the preservation of the demographic potential of the nation

ANALISIS PERAN PANCASILA DALAM MEMBENTUK PERDAMAIAN KEBERAGAMAN DAN PERSATUAN

Pancasila is the foundation and ideology of the Indonesian nation and has a function in the life of the Indonesian nation and state. The meaning of Pancasila includes fundamental values that strengthen diversity, unity, and integrity in the midst of Indonesia's diverse ethnic, religious, cultural, and linguistic communities. In the context of the nation's future, Pancasila has great relevance in building a strong foundation for sustainable development and progress for the Indonesian nation. Pancasila has an important meaning for the future of the Indonesian nation because it is able to become a guide in achieving state goals, strengthening national unity, and creating social justice for all people. Pancasila remains relevant for the future of the nation because it is able to become a foundation for facing various challenges and changing times. Pancasila encourages sustainable, democratic, and socially just development. Pancasila is also able to be a means of strengthening national unity and avoiding horizontal conflict. In addition, Pancasila is able to maintain cultural and religious diversity in Indonesia, so as to strengthen tolerance and togetherness between citizens

Specifics of the embodiment of European genre models in Chinese piano music as the basis of performance stylistics

Statement of the problem. A performer who gives “new life" to a composer’s work lets the sound world of music pass through him. In this process, the genre-stylistic “inclination” of the work becomes a signpost on the way to the realization and improvement of its performance style. The article accents the significant of the relating the genre and performance stylistics. From this viewpoint, the Chinese piano works based on the European genre models are considered in the article. Objectives, methods, and novelty of the research. The relationship between the genre and the performance style of the piano works of Chinese composers has been out of the focus of musicologists’ attention until today. The purpose of the article is to consider the specifics of the embodiment of European genre models (such as prelude, sonata, variations) in Chinese piano music as the basis of their performance stylistics. Achieving the goal required a systematic musicological approach and the involvement of historical-typological, musicalaesthetic, genre-stylistic, structural-functional, and interpretative research methods. Research results and conclusion. The samples of Chinese piano music (preludes, sonatas, variations) demonstrate that the specified group of works preserved their constant genre features, while the nationally directed means of expression were adapted to the norms of the European genre matrix, which in many ways contradicted the national ideas and mental foundations of Chinese musical art. The piano prelude genre has become very popular in the works of Chinese composers. All elements of the national musical style, closely related to the deep roots of Chinese musical and, more broadly, artistic thinking, are involved in the process of “concentrating” energy in miniature form with special laconic and aphoristic expression. The complex large-scale structure of the sonata genre promotes the principle of “activity”, offering the performer various musical ideas and emotions. The mental foundations of Chinese art were significantly adapted, especially in the first part – the sonata allegro, where tonal, figurative and textural contrast is the basis of the interaction of themes. New methods of folklore implementation, in which the role of language-creating and form-creating attitudes is growing, have a perceptible influence on the sonata work of Chinese composers. The European genre model of variations reveals new prospects for its development in combination with a freer national model of variations inherent in Chinese music. There is a peculiar “rational” approach to free variation, “ordering” according to the textural, tonal, figurative principle. Thus, the ccomposers try to “inscribe” national mode and intonation means of expression and performance techniques into the structure of the European genre. At the same time, under the influence of the Chinese traditional system of thinking, European genre models receive a certain “national” interpretation, although the features of a specific sample of the European genre remain as dominant, which determines the style of performing these composition. Such works – diverse and interesting – serve to develop the pianist’s performance skills and gain the widest recognition in the repertoire of many contemporary performers.

Implementation of stroke care & road safety in India: Lessons from Australia.

India is home to one-fifth of the world's population and is currently the fastest-growing economy. As the health industry is growing, India needs to develop robust implementation of evidence-based health care addressing the major public health issues. Two of such issues India is grappling with are the establishment of stroke care and the reduction of road accidents. Australia has achieved notable success in implementing stroke care and reducing road accidents. In stroke, Australian initiatives include dedicated stroke units, the development of clinical guidelines, the implementation of acute interventions, the establishment of a national stroke foundation, and the stroke registry. As a result, the combined, primary, and secondary prevention measures, acute treatment, and rehabilitation have reduced the total disease burden of stroke from 2003 to 2023 by 53 per cent, from 7.4 to 3.5 Disability Adjusted Life Years (DALYS) per 1,000 population, which is a 56 per cent decline in fatal burden and 23 per cent decline in non-fatal burden. For road safety, Australia implemented evidence-based practices such as education, legislation including mandatory use of seat belts, and other road safety initiatives. Data show that seat belt use reached 98 per cent in Australia in 2023. Furthermore, about 20 per cent of drivers as well as passengers who were killed in crashes in 2024 did not wear seat belts. The reduction of speed limits in built-up areas, the adoption of monitoring technology, and the clever use of infrastructure are proving to be effective in reducing fatalities and serious injuries. Australia's implementation research can provide valuable insights into the efforts of mitigating the impact of stroke and enhancing road safety in India.

The effect of social media marketing activities dimensions on value co-creation behavior: An application of the commitment-trust theory

Previous studies have not paid much attention to the effect of social media marketing activities on value co-creation behavior. Especially, up to now, no one has studied the effects of social media marketing activities dimensions on value co-creation behavior. This study applies the commitment-trust theory to develop and estimate this relationship through brand trust and brand commitment on social media in Vietnam. The snowball sampling technique was applied to gather 504 social media users through social media platforms in Vietnam. The proposed research model was tested through PLS-SEM using SmartPLS 4. The results highlighted that most social media marketing activities dimensions (including trendiness, electronic word of mouth, interaction, and customization) affect brand trust (pc are 0.42, 0.152, 0.112, 0.097, respectively, and p-values are all less than 0.05). Simultaneously, brand trust was found to have a positive effect on brand commitment (pc =0.405, p = 0.000). Furthermore, calculation results revealed that brand commitment contributed significantly and strongly to their co-value behavior towards brands (pc = 0.531, p = 0.000). On the contrary, the data do not support a direct impact of entertainment on brand trust (pc = 0.001, p = 0.990) and brand trust on co-value behavior (pc = 0.025, p = 0.466) at a significance level of less than 5%. Ultimately, the findings also suggest a guide to social media marketers to drive customer value co-creation behavior for brands. AcknowledgmentThis work was supported by the National Foundation for Science & Technology Development of Vietnam under Decision No. 131/QD-HDQL-NAFOSTED dated September 21, 2020.

Ectodermal dysplasia and cholesteatoma: A cross-sectional analysis of otologic issues

ObjectivesPrevious studies have also associated cleft palate with increased cholesteatoma risk. Despite this close relation, the incidence of cholesteatoma and associated otologic issues in patients with ectodermal dysplasia types highly associated with cleft palate (EDT-ACPs) has not been formally analyzed. This study provides insight to guide clinicians caring for patients with ED types associated with cleft palate. MethodsIndividuals with TP63 disorders and Goltz syndrome/Focal Dermal Hypoplasia in the National Foundation for Ectodermal Dysplasia database were contacted for participation in an online REDCap survey from Sept–Dec ‘22. Descriptive statistics were generated using SAS JMP Pro 17 statistical software. Results65 individuals participated in the survey (response rate approx. 18 %). The median [IQR] age was 22 [14, 43], 41 (63 %) were female, and Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome (EEC) was most common (n = 26, 40 %). We found that, among our respondents with a history of cleft palate, the incidence of cholesteatoma was 39 %. Among respondents without a history of cleft palate, the incidence of cholesteatoma was 13 % ConclusionsOtologic issues, such as cholesteatoma, can have permanent implications including hearing loss that can be minimized by early identification and treatment. The estimated incidence of cholesteatoma among our participants is far above the estimated incidence of cholesteatoma in the general population with and without a history of cleft palate, suggesting an independent contribution of EDT-ACPs to the risk of cholesteatoma.