Foundational Knowledge Research Articles

QOL-53. EXPLORING HEADACHES IN PEDIATRIC NEURO-ONCOLOGY PATIENTS: A SINGLE INSTITUTION RETROSPECTIVE CHART REVIEW

Abstract BACKGROUND Despite the high prevalence of headaches in pediatric patients with brain tumors, very little research has been done to characterize their traits and to assess current management practices. Effective and efficient treatment of these headaches is critical to the optimization of brain tumor survivors’ quality of life. Foundational knowledge of any clinical associations likely would be beneficial to develop rational management strategies. METHODS A retrospective single-institution chart review of pediatric patients seen in the Children’s Hospital Colorado (CHCO) Neuro-oncology clinic from 1/1/22-12/31/22 is underway. Information is being collected via manual chart review including basic demographic information, oncologic diagnosis and tumor location, surgical interventions, and tumor-directed treatments. Headache characteristics, including timing of onset, associated symptoms, severity and frequency, referral to CHCO Neurology Headache Clinic and any headache therapies attempted will be sought. Additional information will include the number of emergency department visits and unplanned MRIs obtained as part of headache management. RESULTS 384 patients (53% male; median age 12 years, range 2-24 years) received care in the CHCO Neuro-oncology clinic in 2022. The majority of these patients were Caucasian/Non-Hispanic (61.7%), followed by Caucasian/Hispanic (13.8%) and African American/Non-Hispanic (4.2%). In this cohort, the preferred language for 93% was English and for 6% was Spanish. The majority (55%) of patients had a low-grade glioma/ glioneuronal tumor as their oncologic diagnosis. Patients with referrals to CHCO Headache clinic made up 13% of this cohort. Data collection and analysis are ongoing. CONCLUSIONS This data set will help to characterize the prevalence and features of headaches in pediatric patients with CNS tumors. This information will serve as the foundation for planned prospective studies that will collect more comprehensive and consistent data related to headaches in the pediatric neuro-oncology population and to formalize processes that will identify appropriate patients for referral to specialized headache providers.

LC-HRMS-based metabolomics and lipidomics analyses of a novel probiotic Akkermansia Muciniphila in response to different nutritional stimulations

The mucin-degrading gut commensal Akkermansia muciniphila (A. muciniphila) negatively correlates with various diseases, including metabolic disorders, neurodegenerative disorders, and cancers, through interacting with host receptors by diverse molecules. Still, their exact metabolic capability within the nutrient-rich environment (such as in the human gut) is not fully characterized. Therefore, in the present study, we investigated the comprehensive metabolome and lipidome of A. muciniphila after supplementation of four major gut microbial nutrients: mucin, inorganic salts, bile salts, and short-chain fatty acids (SCFAs). Our results showed that mucin is the predominant driver of the different lipidomic and metabolomic profiles of A. muciniphila, and it promotes the overall growth of this bacteria. While the addition of inorganic salts, bile salts, and SCFAs was found to inhibit the growth of A. muciniphila. Interestingly, inorganic salts affected the purine metabolism in A. muciniphila cultures, while adding bile salts significantly increased the production of other bile acids and N-acyl amides. Lastly, SCFAs were identified to alter the A. muciniphila energy utilization of triglycerides, fatty acyls, and phosphatidylethanolamines. To our knowledge, this is the first study to examine the comprehensive lipidome and metabolome of A. muciniphila, which highlights the importance of nutritional impacts on the lipidome and metabolome of A. muciniphila and hence providing foundational knowledge to unveil the potential effects of A. muciniphila on host health.

Dementia and metabolic syndrome: a bibliometric analysis.

Dementia is a progressive neurodegenerative condition, while metabolic syndrome (MetS) is characterized by a combination of metabolic abnormalities such as hypertension, high blood sugar, and obesity. There exists a connection and overlap between the two conditions in certain aspects, and both are influenced to varying degrees by the process of aging. This study presents an overview of the current research landscape regarding dementia and MetS through bibliometric analysis. A systematic search was conducted to retrieve relevant literature on dementia and MetS published between 1 January 2000, and 30 November 2023, from the Web of Science Core Collection database. Various bibliometric tools, including VOSviewer, CiteSpace, and the R software package "bibliometrix," were utilized for analysis. A total of 717 articles were identified, showing an upward trend in annual publications. Leading contributors included the United States, Italy, and China, with institutions such as the University of California System at the forefront. The Journal of Alzheimer's Disease emerged as the top publisher, while research published in Neurology garnered significant citations. Noteworthy authors encompassed Panza, Francesco; Frisardi, Vincenza; and Feldman, Eva L, with Kristine Yaffe being the most cited author (280 citations). Recent studies have focused on themes like "gut microbiota," "neuroinflammation," "fatty acids," and "microglia." This bibliometric analysis summarizes the foundational knowledge structure in the realm of dementia and MetS from 2000 to 2023. By highlighting current research frontiers and trending topics, this analysis serves as a valuable reference for researchers in the field.

Training Architects as Activists: Social Sustainably in the Studio

This paper discusses the application of social sustainability to architecture through a second-year graduate architecture studio focused on urban buildings. I designed the Urban Design Studio in such a way that future faculty could choose assignments between five socially sustainable equity issues: housing, food insecurity, transportation equity, access to opportunities, and environmental health. This supports the Rochester Institute of Technology (RIT) graduate curriculum by focusing on sustainable practices, including activism in architecture. Using the built environment as a platform, the students learn to promote equity, especially in the urban environment. The students research on equity topics, adopt a position on a selected issue, and begin to develop a site, program, and building form around their issue. Architecture has a unique ability to influence social sustainability through equity, especially if we shift our design practices to support disenfranchised populations. Buildings can provide more than social markers. They can create locations that empower local communities. The question is, how do we teach a process that instills this as foundational to quality design? My studio’s process not only establishes a foundational knowledge of building within an urban context, but also provides a firm grounding of activism as central to architectural practice.

Navigating the Online Classroom: Developing Online Teaching Skills in Graduate Public Health & Health Professions Education

The absence of targeted online teaching development opportunities in graduate education may hamper faculty readiness to ensure engagement, learning, and student success in the online learning environment. Faculty are often hired for their subject matter expertise rather than their proficiency in teaching online. Student and faculty success in the online environment requires foundational teaching knowledge and an understanding of the differences between traditional and online teaching. A 4-week asynchronous course was designed to mirror a real-world online course aimed at educating educators. The course consisted of foundational learning theories and practices, curriculum and course design, engagement and presence, and course delivery methods. The course was offered 10 times over 3 years and completed by 258 public health and health profession faculty, teaching and postdoctoral staff, and doctoral students. End-of-course evaluations indicated that participants found it valuable to be in an online course in the student role and felt more prepared to teach online. The teaching online professional development course has highlighted the importance of new or continuing faculty development in asynchronous learning.

Molecular Regulation of Thermogenic Mechanisms in Beige Adipocytes.

Adipose tissue is conventionally recognized as a metabolic organ responsible for storing energy. However, a proportion of adipose tissue also functions as a thermogenic organ, contributing to the inhibition of weight gain and prevention of metabolic diseases. In recent years, there has been significant progress in the study of thermogenic fats, particularly brown adipose tissue (BAT). Despite this progress, the mechanism underlying thermogenesis in beige adipose tissue remains highly controversial. It is widely acknowledged that beige adipose tissue has three additional thermogenic mechanisms in addition to the conventional UCP1-dependent thermogenesis: Ca2+ cycling thermogenesis, creatine substrate cycling thermogenesis, and triacylglycerol/fatty acid cycling thermogenesis. This paper delves into these three mechanisms and reviews the latest advancements in the molecular regulation of thermogenesis from the molecular genetic perspective. The objective of this review is to provide readers with a foundation of knowledge regarding the beige fats and a foundation for future research into the mechanisms of this process, which may lead to the development of new strategies for maintaining human health.

A global dataset for assessing nitrogen-related plant traits using drone imagery in major field crop species

Enhancing rapid phenotyping for key plant traits, such as biomass and nitrogen content, is critical for effectively monitoring crop growth and maximizing yield. Studies have explored the relationship between vegetation indices (VIs) and plant traits using drone imagery. However, there is a gap in the literature regarding data availability, accessible datasets. Based on this context, we conducted a systematic review to retrieve relevant data worldwide on the state of the art in drone-based plant trait assessment. The final dataset consists of 41 peer-reviewed papers with 11,189 observations for 11 major crop species distributed across 13 countries. It focuses on the association of plant traits with VIs at different growth/phenological stages. This dataset provides foundational knowledge on the key VIs to focus for phenotyping key plant traits. In addition, future updates to this dataset may include new open datasets. Our goal is to continually update this dataset, encourage collaboration and data inclusion, and thereby facilitate a more rapid advance of phenotyping for critical plant traits to increase yield gains over time.

Assessing the Initial Outcomes of a Blended Learning Course for Teachers Facilitating Astronomy Activities for Young Children

Globally, astronomy education is being promoted through curricula. Research indicates that educators need support to fundamentally comprehend and gain knowledge of astronomy as well as pedagogical expertise to organize and facilitate astronomy-related activities in the classroom. In response to this notable demand, we have designed a coherent training program that addresses both the foundational and pedagogical content knowledge necessary to instruct astronomy subjects at the pre-primary and early school levels. This program is constructed in a blended learning format, which combines online and in-person training with practical implementations in the classroom. We trained both professional and student kindergarten teachers, and we used questionnaires and interviews to evaluate and improve our training program. In this article, we present the results of our initial evaluation. We found that the student teachers showed a more significant improvement in their content knowledge, pedagogical content knowledge, and instruction preferences compared to the professional teachers. However, we identified several areas for improvement, which will be addressed in future cycles of the program for further evaluation.

Teaching Green Chemistry and Engineering through the Epoxidation of Poly-β-myrcene.

This study explores the application of the epoxidation process of poly-β-myrcene, a constituent of the natural resin from Chios Mastic trees (Pistacia Lentiscus L.), as an educational instrument for teaching Green Chemistry and Engineering to students at various academic levels. The study provides a comprehensive presentation of foundational knowledge essential for interpreting the subsequent experimental data. Consequently, the production process that leads to the production of Mastic Epoxide (MASTEP) stands as an invaluable pedagogical resource, enabling educators to impart crucial principles of Green Chemistry and Engineering to both pre-graduate and post-graduate students. By employing MASTEP as a case study, this educational approach actively involves students in a dynamic learning environment. Through this methodology, learners develop a profound comprehension of sustainability, innovation, and good practices. The integration of the MASTEP concept into the curriculum would foster a deeper understanding of responsible methodologies among aspiring chemical engineers and scientists, equipping them to make substantial contributions towards a more sustainable global landscape. This educational model aims to contribute to preparing future generations for a pivotal role in fostering a sustainable world through their professional endeavors.

Development of a professional oncology navigation training and credentialing program: ACS Leadership in Oncology Navigation (ACS LION).

9045 Background: Navigation by trained professionals is a key component to improving cancer outcomes in the US, helping to ensure every cancer patient has access to timely, quality, and culturally competent care. Due to limited standardized training and lack of sustainable funding for navigation, patients are not receiving the comprehensive care they deserve. The new Center for Medicare (CMS) 2024 physician fee schedule pathway for reimbursement of non-clinical patient navigation (PN) offers a pathway to create sustainable oncology navigation. Methods: The American Cancer Society developed the Leadership in Oncology Navigation (ACS LION) training and credentialing program with the goal of increasing access to high quality, standardized navigation training in compliance with Medicare requirements and in alignment with the Oncology Navigation Standards of Professional Practice. The program includes 10 learning modules and associated quizzes and a final summative assessment that is remotely live-proctored to demonstrate learning comprehension. This mixed methods analysis includes program descriptive data and paired t-tests of pre- and post-course comprehension and qualitative thematic analysis of open-ended survey responses. Results: The ACS LION program was piloted among 11 organizations nationally, including both academic health systems and community-based organizations. Of the 79 participants, 23% were Black and 14% were Hispanic. 18% of participants had less than one year of experience and 29% had more than 5 years of experience in navigation. 28% held clinical job titles. 51% had organization-specific in-service training and only 11% had taken an external standardized training program. Compared with pre-course scores, the program was significantly associated with higher post-course self-reported comprehension of 9 CMS required PN competencies (p<0.001; p=0.08 for professionalism and ethical conduct). Qualitative analysis revealed 4 themes: learner experience, practicality, comprehensiveness, and role delineation. Post-program ratings averaged 4.5 out of 5.0, including overall learning experience, meeting a need, would recommend to others, and enhanced their professional experience. Conclusions: Pilot participants from diverse racial, ethnic, and work experience backgrounds found ACS LION to be comprehensive, engaging, and provided either critical foundational knowledge for less experienced navigators or enhanced their existing knowledge for experienced navigators, providing practical tools and resources. Pilot results informed the course that was launched nationally on Jan 1, 2024. Webinars, learning collaboratives, refresher courses, and re-credentialing will continue to be developed and offered as part of ACS LION and ACS commitment to advancing high quality professional navigation.

Educating and empowering health care teams who present to the hospital to recognize and intervene on cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) in patients on bispecific t-cell engager therapy (BiTEs): A quality improvement study.

e23212 Background: Treatment of oncologic disease with Bispecific T-Cell Engager antibodies (BiTEs) are an emerging novel immunotherapy with demonstrated efficacy in multiple hematologic malignancies. Notable side effects of BiTE therapy include cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), which can be life-threatening and must be rapidly identified. We aim to fill knowledge gaps surrounding CRS and ICANS for medical providers, particularly considering increased use of BiTE therapy. We hope that educating providers will allow faster recognition and treatment and will improve patient outcomes. Methods: Our study focused on the impact of educational presentations on awareness and identification of CRS/ICANS. Our intervention targeted the residents and attendings in the emergency department and the nurses, advanced practice providers, and hospitalists in the bone marrow transplant (BMT) unit at Stony Brook University Hospital. Anonymous surveys consisting of 9 multiple choice questions were conducted to assess baseline foundational knowledge of CRS/ICANS. QI consisted of a 15-minute educational presentation for both groups. The same surveys were repeated following the presentations to assess improvement in overall knowledge of CRS/ICANS. A two tailed independent T test was used to calculate significance. Results: The average pre-survey score for the emergency department (N = 37) was 39%. The average presurvey score for the BMT department (N = 13) was 45%. Significant improvements in scores after intervention were shown in both the emergency department (39% vs 66%, p = 0.0001) and the BMT department (45% vs 68%, p = 0.0006). Conclusions: Education among emergency department and hospitalist providers is essential in improving management of CRS and ICANS in patients treated with BiTEs. This quality improvement initiative confirmed a knowledge gap in CRS and ICANS amongst our healthcare teams. By providing educational resources to both departments, there was a significant improvement in this gap. Future directions for continued improvement in the detection and management of CRS/ICANS include patient medication identification cards, a central repository of treatment protocols, algorithms, and toxicities associated with BiTEs, and expanding our educational curriculum which are all currently under development at Stony Brook University Hospital.

Generalized functionals for qualification of geological carbon storage injection sites

Many nations have pledged to reach carbon neutrality by 2050. Embarking on the decarbonization journey, they posited geological carbon storage (GCS) as a pivotal technology within the carbon capture, utilization, and storage (CCUS) framework. The CCUS chain operates to reduce “hard-to-abate” emissions at key sectors by capturing carbon dioxide (CO2), reusing it, transporting it, or disposing of it via injection into underground geological formations for permanent storage. Despite the global success of GCS ventures, mainly driven by the oil and gas industry, GCS initiatives are still in their early stages in several developing countries. In Brazil, for instance, a full setup covering precise storage capacity databases, potential CCUS clusters, national regulatory structure, and auxiliary computer-aided engineering is underway. Intended to push the frontier in the latter subject, this paper introduces mathematical models for qualifying underground CO2 storage sites. Our research explores a family of multivariate functionals endowed with underlying reservoir features and distinct weighting functions, thus envisioning two primary objectives. Firstly, it clarifies non-linear interactions between rock and fluid properties using quality indicators. Secondly, it evaluates geographical regions considering structural traps/caprocks settings. Backed by the Matlab Reservoir Simulation Toolbox (MRST) capabilities, the methodology is a subsidiary resource for identifying suitable injection and storage sites. A case study using the UNISIM-I-D model generated dozens of volumetric quality maps that point to unique potential storage sites. Numerical simulation experiments of injection comparing legacy and novel wells reveal storage surpluses improved by up to 50%. The paper seeks to establish foundational knowledge in GCS efficiency for general underground settings. One expects that these outcomes leverage well-repurposing perspectives and stimulate field appraisal actions to scale up GCS projects both in Brazil and worldwide.

EFFECTIVENESS OF MENTAL MATH STRATEGY IN TEACHING MATHEMATICS TO GRADE 1 LEARNERS

The research findings unveil significant insights into the effectiveness of a mental math strategy in enhancing the mathematical performance of grade 1 learners. Initially, both control and experimental groups exhibited satisfactory performance attributed to foundational knowledge acquired in kindergarten and initial grade 1 lessons on addition and subtraction. Following the implementation of the mental math strategy, the control group maintained their satisfactory performance, while the experimental group showed remarkable improvement, highlighting the efficacy of instructional materials and drills associated with mental math. Moreover, techniques such as counting up or back and the use of number lines proved effective in augmenting students' mathematical abilities. Based on these findings, several recommendations are proposed. Firstly, schools and educators are urged to continue enriching students' understanding of whole number concepts using diverse instructional materials and technological resources. Secondly, teachers are encouraged to integrate mental math strategies into their teaching practices, leveraging various learning aids and visual tools to facilitate comprehension. Additionally, both educators and parents are advised to employ counting techniques and number lines through interactive methods such as games and drills to enhance math learning outcomes. Lastly, collaborative learning environments should be fostered, allowing students to engage in problem-solving tasks together, thereby promoting teamwork and peer support while utilizing different mental math strategies. The study's Design and Methodology section provides a comprehensive outline of the research approach, including data collection tools and ethical considerations, employing a descriptive quantitative method to evaluate the efficacy of the mental math strategy in teaching addition.

Using Case-Based Instruction to Support Teaching Self-Efficacy for Cultural Responsiveness in Pre-Service Teachers: A Mixed Methods Study

Using a mixed methods design we quantitively examined how case-based instruction (CBI) influenced preservice teachers’ (PSTs) cultural responsiveness teacher efficacy development across three classroom case studies. Qualitatively, we examined how PSTs were able to engage in self-insertion when writing about their reactions to the classroom cases. Specifically, PSTs were randomly assigned to one of two conditions; one group received a content-based text excerpt prior to reading and responding to two classroom cases (Text–Case). Another group was given a series of three classroom cases (Case–Case) that contained similar information to the Text–Case group. The Text–Case group maintained their cultural responsiveness teacher efficacy compared to the Case–Case group, which showed a significant decline (<em>p</em> < 0.05). The Text–Case group also showed greater self-insertion in their responses to the cases. These findings provide evidence that CBI paired with foundational knowledge was more effective than CBI alone.

Personalized System of Instruction for the Foundational Knowledge of Organic Chemistry

Personalized System of Instruction for the Foundational Knowledge of Organic Chemistry

The Effect Of Teaching Basics Of English Morphology On EFL Students' Vocabulary Mastery

This study investigates the impact of introducing the basics of English morphology to English as a Foreign Language (EFL) students. Morphology, the study of word formation and structure, is fundamental to understanding and mastering any language. The research focuses on how foundational knowledge of English morphology influences EFL students' language acquisition and proficiency. By incorporating morphological instruction into the curriculum, students can enhance their vocabulary, improve their reading comprehension, and develop a deeper understanding of grammatical structures. The study involved a group of EFL students who received systematic instruction in morphology, including the identification and usage of roots, prefixes, and suffixes. Pre- and post-tests were administered to measure the student's progress. The results indicated a significant improvement in the student's linguistic skills, particularly their ability to decode and construct words and overall language comprehension. The findings suggest that integrating morphology into EFL teaching strategies can provide substantial benefits, facilitating more effective language learning and boosting students' confidence in English. This research underscores the importance of morphological awareness in EFL education and offers practical implications for educators aiming to enhance their teaching methods to support student success in acquiring English.

Penggunaan Kolase Dalam Meningkatkan Motorik Anak Usia Dini Di Ra Yaa Bunayya Desa Mompang Julu

Early childhood education plays a crucial role in preparing children with foundational knowledge for further education at the primary level. Within Early Childhood Education (ECE), children are nurtured to become independent individuals, fostering social interaction, strong self-confidence, a keen interest in exploring knowledge, the ability to adopt positive ideas, develop their own thoughts, adapt to new environments, demonstrate high enthusiasm for learning, and exhibit high levels of creativity. Early childhood education, including preschool education, aids in the physical and mental development of children, covering various aspects such as religious and moral values, social, emotional, cognitive, linguistic, and motor skills. This education can be conducted through various pathways, including formal, informal, and non-formal, with one form being the Integrated Early Childhood Education (IECE) program. The collage method serves as an effective approach to enhance children's fine motor skills, optimally implemented in several IECE institutions like RA Yaa Bunayya in Mompang Julu Village. Qualitative methods are employed in this research, utilizing triangulation data collection techniques comprising observation, interviews, and documentation. Collage activities at RA Yaa Bunayya are planned according to the children's needs, utilizing safe and diverse natural materials, providing valuable experiences for children to explore textures and shapes. Collage activities also offer advantages in improving concentration, recognizing colors, and identifying shapes, which are crucial aspects of children's development.

Towards sustainable solar cells: unveiling the latest developments in bio-nano materials for enhanced DSSC efficiency

Abstract Fossil fuels—instrumental in powering the nineteenth-century Industrial Revolution—are now under heightened scrutiny due to environmental concerns and carbon emissions. Consequently, there is a global impetus towards achieving carbon-neutral energy production, with solar energy emerging as a cornerstone in this transition. Over the past three decades, dye-sensitized solar cells (DSSCs) have gained increasing prominence due to their unique advantages. This review elucidates several crucial elements essential to DSSC construction, notably bio-nano materials, prized for their structural flexibility, cost-effectiveness and high molar absorption coefficient. It delves into the intricate relationship between molecular structure and DSSC performance, showcasing significant advancements with light-to-power conversion efficiencies reaching 11%. A comprehensive analysis of the photovoltaic performance of DSSCs utilizing bio-nano-based dyes offers invaluable insights into the state of this rapidly evolving industry. Key components under scrutiny include transparent conductive oxide (TCO) layers, physical techniques for metal oxide deposition onto TCO thin films, diverse dye variants and foundational knowledge of components ripe for growth and enhancement. Moreover, the review outlines the latest breakthroughs in the field, providing glimpses into the current status of prototype DSSCs.

Gender Identity in Forensic Death Investigation: A Narrative Review and Suggested Guidelines for Documenting and Reporting.

In the current body of forensic literature, there is little guidance available regarding death investigations of transgender, intersex, and gender diverse individuals. An increase in the prevalence of gender diverse identifying people and the frequency in which these individuals experience a premature death makes it more likely these deaths will fall under the jurisdiction of the medical examiner's office. The inability to navigate these diverse cases due to a lack of training, education, and support may leave forensic professionals without the tools needed to accurately represent these deaths.This narrative review is intended to provide the foundational knowledge needed by forensic death investigators when investigating gender identity in death, including suggested guidelines for a more effective and empathetic death investigation. A better understanding of the implications and applications of this information when included in reports will bolster the quality and quantity of the data reported and collected. This will lead to more accurate monitoring and reporting of violent, suicidal, and homicidal deaths of transgender, intersex, and other gender diverse individuals, and a higher identification rate of unidentified remains with gender diverse markers.

Challenges and best practices for recruiting families of children with intellectual disabilities for health research.

Research focused on children with intellectual disabilities has been of increasing interest over the last two decades. However, a considerable lag in the amount of research that is representative and generalizable to this population in comparison to neurotypical children remains, largely attributed to issues with participant engagement and recruitment. Challenges and barriers associated with engaging and recruiting this population include lack of research to provide a sound foundation of knowledge, ethical considerations, parental attitudes, family commitments, and organizational gatekeeping. Researchers can engage children and their families using participatory research methods, honouring the child's right to assent, and collaborating with parents. Recruitment strategies include partnering with organizations, working with parent and patient partners, and using remote methods. Employing evidence-informed engagement and recruitment strategies may provide substantial social and scientific value to the research field by ensuring that this underrepresented population benefits equitably from research findings.