Objective. The purpose of the research is to deepen the methodological and applied foundations of knowledge management in the conditions of industrial enterprises intellectualization and digitalization development. Methodology. The methodological basis of the research article is a set of theories and concepts that contribute to a full understanding of the knowledge management process of the content at an enterprise in the context of intellectualization and digitalization: theories of knowledge economy, entrepreneurship, institutionalism, microeconomic theory of knowledge management, theory of new knowledge acquisition; the concept of information society; the concept of intellectual capital; the concept of social capital. The methodology is based on system analysis as a scientific method of researching the enterprise knowledge management functions. The study used quantitative and qualitative methods of data and information collection and analysis; methods of analytical, situational analysis and synthesis; comparative analysis, generalization of scientific experience of modern theoretical research, and a systemic and integrated approach. Results. The article outlines the important role of knowledge management in creating competitive advantages, increasing the value of enterprises and ensuring their long-term sustainable development. A new understanding of the essence of the categories of “knowledge management of an industrial enterprise” and “knowledge management system of an industrial enterprise” has been proposed. A theoretical generalization of the concept of knowledge management of industrial enterprises has been carried out. The article describes new trends in the knowledge management system based on the synergistic relationship between technological components and behavioral aspects in management. The scientific novelty lies in improving the methodology and concept of an integrated knowledge management system and methodological support for its effective practical application. The implementation of the knowledge management system in the conditions of intellectualization and digitalization is substantiated, which improves knowledge accumulation processes, integrates knowledge into the field of the enterprise activity and ensures the exchange of knowledge between employees and key stakeholders. Modern knowledge management tools that enable intellectualization and high-quality digitalization of an enterprise are identified. Recommendations for improving knowledge management at industrial enterprises have been developed, as well as mechanisms for their practical implementation have been proposed. Practical significance of the obtained results. The author’s developments and recommendations can be used to effectively use the intellectual potential of an enterprises to increase economic added value through the growth of organizational knowledge.