Event Abstract Back to Event Beamformer analysis of fetal MEG data with intermittent nonstationarity Jack McCubbin1*, Pamela Murphy1, Maureen Ware1, Eric Siegel1, Hari Eswaran1, Jiri Vrba2, Curtis Lowery1 and Hubert Preissl3 1 UAMS, United States 2 UAMS, Elekta Neuromag, United States 3 U. Tuebingen , UAMS, United States MEG recordings from subjects such as fetus, newborn, or child may have intermittent nonstationarity. In the case of fetal MEG, the data is characterized by frequent subject movements, complex near-field interference structure, and limited duration records. Beamformer provides a good spatial filter for the near-field interferers however the method assumes stationary data and static forward model parameters. The poor knowledge of origin for the fetal head model sphere has been addressed by scanning over a grid of origins as well as model source grids within each model sphere. Recently, the effect of subject movement has been minimized by using a sliding analysis window along the full record duration and selecting statistically significant clusters of activity in the statistical parametric map for each window using random field theory. The expected reduction of latency with increasing gestational age was observed with that processing scheme for a series of low-risk pregnancies, providing a validation of the beamformer method. The procedure has since been refined by the addition of an MCG interference leakage criterion and replacement of the manual latency estimation with a semi-automated method to reduce operator bias. The processing was applied to a series of high-risk fetal MEG records which included fetal ultrasound surveillance data. We found that both umbilical artery and middle cerebral artery Doppler measures were correlated with visual flash-evoked latency estimates. Since both Doppler measures and latency are normally correlated with fetal development, these results provide additional evidence for reliable latency estimates from beamformer processing and may lead to a new measure for direct fetal neurological development to complement existing surveillance measures. In addition, this processing strategy may be adaptable to other situations with intermittent nonstationarity. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: Fetal and neonatal biomagnetism Citation: McCubbin J, Murphy P, Ware M, Siegel E, Eswaran H, Vrba J, Lowery C and Preissl H (2010). Beamformer analysis of fetal MEG data with intermittent nonstationarity. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00132 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Mar 2010; Published Online: 24 Mar 2010. * Correspondence: Jack McCubbin, UAMS, Little Rock, United States, mccubbin@telus.net Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jack McCubbin Pamela Murphy Maureen Ware Eric Siegel Hari Eswaran Jiri Vrba Curtis Lowery Hubert Preissl Google Jack McCubbin Pamela Murphy Maureen Ware Eric Siegel Hari Eswaran Jiri Vrba Curtis Lowery Hubert Preissl Google Scholar Jack McCubbin Pamela Murphy Maureen Ware Eric Siegel Hari Eswaran Jiri Vrba Curtis Lowery Hubert Preissl PubMed Jack McCubbin Pamela Murphy Maureen Ware Eric Siegel Hari Eswaran Jiri Vrba Curtis Lowery Hubert Preissl Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
Read full abstract