Saigo and Maeda (Transform Methods and Special Functions, Varna, Bulgaria, pp. 386-400, 1996) introduced and investigated certain generalized fractional integral and derivative operators involving the Appell function . Here we aim at presenting four unified fractional integral and derivative formulas of Saigo and Maeda type, which are involved in a product of ℵ-function and a general class of multivariable polynomials. The main results, being of general nature, are shown to be some unification and extension of many known formulas given, for example, by Saigo and Maeda (Transform Methods and Special Functions, Varna, Bulgaria, pp. 386-400, 1996), Saxena et al. (Kuwait J. Sci. Eng. 35(1A):1-20, 2008), Srivastava and Garg (Rev. Roum. Phys. 32:685-692, 1987), Srivastava et al. (J. Math. Anal. Appl.193:373-389, 1995) and so on. Our main results are also shown to be further specialized to yield a large number of known and (presumably) new formulas involving, for instance, Saigo fractional calculus operators, several special functions such as H-function, I-function, Mittag-Leffler function, generalized Wright hypergeometric function, generalized Bessel-Maitland function. MSC:26A33, 33E20, 33C45, 33C60, 33C70.