Prescription Form Research Articles

AI-driven business analytics for SMES: Unlocking value through predictive and prescriptive analytic

Introduction: With an emphasis on predictive and prescriptive analytics, this study examines the revolutionary implications of AI-driven analytics on small and medium-sized organizations (SMEs). SMEs play a crucial role in the global economy and require advanced solutions to improve decision-making and operational efficiency. The research aims to explore how AI-powered analytics, particularly in predictive and prescriptive forms, can add value to SMEs by enhancing demand forecasting, customer behavior insights, and financial planning. To determine how AI-driven analytics might affect SMEs, a thorough assessment of the literature was undertaken. The study reveals that SMEs implementing predictive analytics experience notable improvements in areas such as inventory management, revenue generation, and overall operational efficiency. Furthermore, businesses that leverage prescriptive analytics benefit from optimized resource allocation, enhanced marketing strategies, and better risk management practices. These findings highlight the potential for AI to overcome key challenges faced by SMEs, including budget constraints and limited data availability. AI-driven analytics can provide valuable insights that allow SMEs to streamline operations and foster growth. With future trends pointing to greater accessibility and developments in machine learning, natural language processing, and the integration of AI with other cutting-edge technologies, like blockchain, AI-powered analytics offers substantial prospects for small and medium-sized enterprises.

PROTOCOLOS TERAPÊUTICOS PARA O TRATAMENTO DA ESPOROTRICOSE FELINA REFRATÁRIA E INOVAÇÕES DECORRENTES DAS PESQUISAS

Sporotrichosis in felines is much more pathogenic than in other animals or in humans, even if immunocompetent, which makes treatment a challenge in clinical medicine, as many of them are refractory to the preferred therapy such as Itraconazole or Ketoconazole. This situation also arises from the prolonged oral administration of the medication, the animal's reluctance to take the drug and the guardian's abandonment of the prescription when he notices an improvement in the lesions caused by the disease, which generates relapses and resistance to the antifungals available on the market. Itraconazole, as well as Ketoconazole, act by causing permeability of the plasma membrane and cell necrosis, however, they have adverse effects such as nausea and vomiting in the first and liver disease as relevance in the second. Terbinafine works by interrupting the synthesis of ergosterol and as a consequence the cell membrane ruptures and death, however, it also has side effects such as gastrointestinal and skin problems. Potassium iodide can be used in combination with azoles or Terbinafine, although the literature does not agree with the issue, as not all felines respond to treatment, adverse effects are due to iodism such as depression, anorexia, vomiting and diarrhea. There are also alternative treatments that can enhance oral medication, such as laser therapy, ozone therapy, cryotherapy and cryosurgery. Due to the issue of non-responsive felines, there is research being developed aiming to provide new therapeutic horizons for these animals, such as the use of intranasal infusion of 1% Clotrimazole spray associated with Itraconazole added with Potassium iodide or not, with good results, no relapses and no side effects. NikZ, the result of a substance produced by the bacterium Streptomyces tendae, called Nikkomycin Z, also appears as a new therapeutic potential for the treatment of Sporotrix spp., with a blocking effect on chitin synthase present in the cell wall of fungi, were maide research with dogs, rats and is in Phase 1 of experiments on humans. NikZ represents a new form of prescription, as it can be placed in the animals' drinking water, avoiding the desertion of those responsible for the felines, it has no observable adverse effects in the analyzes carried out and represents an alternative for cats refractory to existing medical protocols in veterinary.

Медиатизированный дискурс православного студенчества об РПЦ

The article is devoted to the analysis of the modern Orthodox conservative mediatized discourse among student bloggers on the Telegram messenger platform. The relevance of the study lies in the lack of development of both the topic of mediatization of Orthodoxy and the topic of studying Orthodox conservatism in modern sociology. The study of this phenomenon in the work took place through the prism of a conceptual approach, which received the name "mediatization of religion" in scientific sociological literature. The scientific problem is that studies of the mediatization of Orthodoxy are no longer a new field, but their number is still small. A large number of religious groups that are currently forming and functioning are outside the field of view of researchers. The figurative approach, which took shape in the German school of studying mediatization, was chosen as the research method. The figurative approach re-actualizes the concept of “figuration” by Norbert Elias and considers modern communicative figuration in media through four components: communicative practices, media ensemble, frame of relevance and constellation of actors. The communicative figuration of modern Orthodox conservatism in the Telegram messenger was taken as the basis of our study, since this platform provides opportunities for discussion on social and theological issues. The purpose of the article is to describe this communicative figuration through its four components. In this regard, the objectives of the study were: a description of the context of formation and features of the modern stage of studying the mediatization of Orthodoxy; a characteristic of the 4 components of the communicative figuration of modern Orthodox conservatism among young people. The empirical part of the study was based on a series of expert, semi-structured interviews with the authors of Telegram channels included in the youth category and who are students of higher educational institutions. In total, 30 interviews were collected from March to August 2024, of which 5 were selected for the article. The results of the study demonstrated that at the moment there is a constellation of actors of modern Orthodox conservatism, in the youth pole of which a group of students can be distinguished. Orthodox conservative students build their own identity, based on the Orthodox tradition, but only in the form of moral prescriptions. They are practically not integrated into the existing structures of the Russian Orthodox Church. The frame of relevance of the communicative figuration of Orthodox conservatism considers Orthodoxy as an integral part of modern Russian culture and humanitarian science. But in the frame, there is also an opposition to liberalism, including church liberalism, which occurs on issues of the foundations of society.

Systematic analysis of traditional Chinese medicine prescriptions provides new insights into drug combination therapy for pox

Ethnopharmacological relevanceThe decline in cross-protection provided by the smallpox vaccine increases the risk of infection from other poxviruses. While drug combinations are a promising management, they remain underdeveloped for poxviruses. Prior to the development of the smallpox vaccine, China had long relied on herbal medicine to combat pox and accumulated a wealth of knowledge regarding different herb combinations and symptoms related to pox. The information was documented in the form of prescriptions. Aim of the studyThe extensive data of prescriptions offer the potential for uncovering commonalities underlying these prescriptions, thereby providing valuable insights into the development of drug combinations against pox. Materials and methodsThe 2344 prescriptions were collected from the LTM-TCM database and 12 traditional Chinese medicine books. Firstly, the relative frequency of citation was utilized to identify the most used herbs among these prescriptions. TCMSP and LTM-TCM databases were employed to gather information about active compounds and their targets. GeneCards and DisGeNET databases were utilized to determine the associated targets for smallpox, cowpox, chickenpox, and mpox. Subsequently, network pharmacology analysis was conducted to investigate potential pathway information related to the most used herbs. A comparison of active compounds from these herbs resulted in the identification of 29 high-frequency compounds. The functions of these compounds were elucidated through gene overlap analysis, docking, and literature review. Finally, we summarized pox-related symptoms and used fidelity levels to distinguish specific herbs for corresponding symptoms. ResultsBased on 2344 traditional pox-related prescriptions, we identified 19 most used herbs and 64 associated bio-functional modules for poxvirus treatment, with the most significant one being immunoregulation primarily involving CD4+ regulation. We also identified 29 leads that possess anti-inflammatory, antimicrobial, and antiviral properties. These herbs and leads hold the potential for pox treatment. Additionally, docking analysis suggested that these leads could inhibit poxvirus DNA synthesis, RNA capping machinery processes, and mature poxvirus particle formation, as well as immunosuppressors. The clinical features of mpox in 2022 were found to align well with our description of symptoms related to the pox. ConclusionThrough the analysis of 2344 prescriptions for pox treatment, we obtained a comprehensive library of the most used herbs and high-frequency compounds, along with their potential functional spectrum. These libraries served as raw resources for drug combination development, while the identified symptom patterns and specific herbs greatly enhanced our insight into diverse treatments for pox patients.

Enhancing antibiotic prescribing practices at the main military training hospital of Tunis: A study of pharmaceutical interventions

Bacterial infections have historically posed significant challenges until the discovery of antibiotics, which revolutionized infectious disease treatment. However, bacterial adaptation mechanisms over time have led to increased antimicrobial resistance, necessitating judicious antibiotic use. This study aims to comprehensively analyze pharmaceutical interventions related to antibiotic prescriptions governed by antibiotic order forms to identify and rectify medication errors, optimizing antibiotic prescribing practices. Approval for this research was obtained from the institutional review board of the Main Military Training Hospital of Tunis, Tunisia. A retrospective study was conducted at the main military training hospital of Tunis over 4 months. Pharmaceutical validation of antibiotic prescriptions through antibiotic order forms was conducted by a pharmacy resident. Pharmaceutical interventions were initiated upon detection of errors, and patient records were accessed through institutional software. Out of 1100 prescription forms analyzed, 41 pharmaceutical interventions were conducted for 7 antibiotics. Twenty-four percent of all interventions were related to antibiotic order forms, with the intensive care unit accounting for the highest number of errors. Under-dosage and prescription errors were common. Our pharmaceutical interventions related to antibiotic order forms are crucial for optimizing antibiotic therapy. Feedback mechanisms to healthcare teams are essential for enhancing prescription quality and patient care outcomes. Ongoing surveillance and improvement efforts are necessary to address medication errors and enhance antimicrobial stewardship.

The experiences of podiatrists prescribing custom foot orthoses and patients using custom foot orthoses for foot pain management in the United Kingdom: A focus group study.

Foot pain can be a significant burden for patients. Custom foot orthoses (CFOs) have been a mainstay in podiatry treatment for foot pain management and improving foot function. However, little is known about podiatrists' experience of prescribing CFOs or patient experience of using foot orthoses (FOs), including CFOs, for foot pain. A focus group (FG) discussion with three FOs users (Female=2 and Male=1) was conducted in November 2022 within a private podiatry practice. This group represented non-experts from the general local population of individuals with existing or previous foot pain who have personally experienced using either over-the-counter FOs or CFOs. An online FG discussion with five musculoskeletal (MSK) specialist podiatrists (Female=2 and Male=3) was also conducted in December 2022. This group represented podiatrists with specialist knowledge in foot biomechanics and clinical experience in CFO provision. The FG discussions were recorded and lasted 49 and 57min respectively. Transcribed data was manually coded, and a thematic analysis was undertaken to identify patterns within the collected data. The participants in the patient FG detailed mixed experiences of the prescription process and CFOs received, with reports of limited involvement/input in their prescription, the need for frequent adjustments and high costs. The impact on footwear choices, replicability and transferability of CFOs into different types of shoes and technologies to aid design were also highlighted. In the podiatrist FG, lack of confidence in design and manufacture processes, prescription form language, relationship and communication building with manufacturers, variability in the CFOs issued and the need for better student education in CFO provision emerged as key themes. Patients and podiatrists shared similar views on CFO provision, namely poorcommunication with manufacturers leading to dissatisfaction with the CFOs prescribed causing negative impacts on patient experiences. Podiatrists called for greater education at registration level to increase new graduate podiatrist knowledge in CFO design and manufacture and better collaboration with manufacturing companies.

Predictors for prescription of noninvasive ventilation in the postoperative period of cardiac surgery: a systematic review

Introduction The postoperative (PO) period after cardiac surgery is associated with the occurrence of respiratory complications. Noninvasive positive pressure ventilation (NIPPV) is largely used as a ventilatory support strategy after the interruption of invasive mechanical ventilation. However, the variables associated with NIPPV prescription are unclear. Objective To describe the literature on predictors of NIPPV prescription in patients during the PO period of cardiac surgery. Materials and methods This systematic review was registered on the International Prospective Register of Systematic Reviews (PROSPERO) platform in December 2021 (CRD42021291973). Bibliographic searches were performed in February 2022 using the PubMed, Lilacs, Embase and PEDro databases, with no year or language restrictions. The Predictors for the prescription of NIPPV were considered among patients who achieved curative NIPPV. Results A total of 349 articles were identified, of which four were deemed eligible and were included in this review. Three studies were retrospective studies, and one was a prospective safety pilot study. The total sample size in each study ranged from 109 to 1657 subjects, with a total of 3456 participants, of whom 283 realized NIPPV. Curative NIPPV was the only form of NIPPV in 75% of the studies, which presented this form of prescription in 5–9% of the total sample size, with men around 65 years old being the majority of the participants receiving curative NIPPV. The main indication for curative NIPPV was acute respiratory failure. Only one study realized prophylactic NIPPV (28% of 32 participants). The main predictors for the prescription of curative NIPPV in the PO period of cardiac surgery observed in this study were elevated body mass index (BMI), hypercapnia, PO lung injury, cardiogenic oedema and pneumonia. Conclusions BMI and lung alterations related to gas exchange disturbances are major predictors for NIPPV prescription in patients during the PO period of cardiac surgery. The identification of these predictors can benefit clinical decision-making regarding the prescription of NIPPV and help conserve human and material resources, thereby preventing the indiscriminate use of NIPPV.

Effect of <i>Bacillus subtilis</i> in combination with chitosan salicylate on peroxidase and catalase activity in <i>B. sorokiniana</i> infected wheat

The aim of the work was to study the effect of Bacillus subtilis strains VKM B‑2604D and VKM B‑2605D which form the basis of the Vitaplan biological product, and their combinations with chitosan salicylate on antioxidant defense enzymes in the process of formation of resistance of wheat plants to infection with the dark brown blotch pathogen Bipolaris sorokiniana. In wheat plants treated with B. subtilis strains and their combinations with chitosan salicylate, upon subsequent infection, catalase and peroxidase are activated, which regulate the intensity of oxidative stress induced by the introduction of the pathogen. Taking into account the data obtained by us, it can be assumed that the increase in plant resistance to the pathogen is realized through the control of the activity of antioxidant enzymes (inparticular, catalase, peroxidase), which maintain the concentration of H2O2 at the level necessary for the neutralization of the phytopathogen in tissues, including the direct destruction of the invading pathogen and / or activation of crosslinking and lignification of the cell wall. These processes strengthen the cell wall and help contain the spread of the pathogen in the plant. At the same time, protective reactions are also switched on, leading to the development of induced resistance in wheat plants to dark brown spotting, which manifests itself in a decrease in the development of the disease by 25–45% relative to the infected control in the treated plants. The obtained results indicate that the combination of active strains of microorganisms-antagonists of plant pathogens and chitosan salicylate is promising for increasing the biological efficiency and expanding the spectrum of action of the developed prescription forms of biological products.

EXERCISE PRESCRIPTION IN CARDIOVASCULAR PREVENTION: PRELIMINARY DATA OF A FIVE YEARS ACTIVITY OF SPORTS MEDICINE UNIT –ULSS 2 TREVISO

Abstract Physical exercise plays a pivotal role in primary and secondary prevention of non–communicable chronic diseases. Nonetheless, to date, exercise prescription to chronically ill subjects is not yet in line with guidelines indications. In Veneto region, the goal of reducing the gap between guidelines and their actual application has been pursued for several years thanks to a regional “model”of exercise prescription in chronic disease. However, regional data indicative of the real clinical impact of this "model" are lacking. We evaluated the impact of the regional model on a population of chronically ill people visited at our Clinic between 2014 and 2019. In this period, 366 subjects living in the province of Treviso (Veneto region, Italy) with a history of heart disease and/or diabetes have been admitted to our facility and have been provided with precise indications (in the form of prescription) about physical exercise to be practiced in secondary prevention. For each subject, adherence to the exercise prescription was assessed. The study population was therefore divided into 3 classes of activity in accordance with the physical activity practiced during the observation period: 0=not adherent at all at the exercise prescription (no exercise practice phase); 1= practice of unstructured physical activity/ not monitored physical exercise and/or not completely adhering to the exercise prescription in terms of intensity, duration and frequency; 2= practice of structured and monitored physical exercise, completely adherent to exercise prescription provided. By this way, any temporary suspension and subsequent resumption of the activity was considered and the period of cessation of the activity during the monitoring period was taken into account for each subject. Data on “health expenditure”, was collected for each subject at time zero as new hospitalizations and deaths were analyzed following our intervention (exercise prescription letter delivery). According to a preliminary analysis of our data, time spent in practicing exercise in class 1 and 2 lead to a significant improvement in survival and less hospitalizations for considered pathologies. Furthermore, time spent in class 2 exercise practice (structured and monitored physical exercise, at target for intensity, duration and frequency), seems to determine even greater protection compared to unstructured physical activity or structured but not monitored and/or non–targeted physical exercise (class 1).

Clinical laboratory techniques for detecting drugs of abuse: Feasibility in developing nations

Drugs of abuse are prescription, over-the-counter, or other forms of drugs that are often used for purposes other than those for which they are meant to be used, or in excessive amounts. The abuse of illicit drugs (for example cocaine, heroin, and codeine) poses a serious threat to public health, not to mention a great challenge to the health care system. It is important to review the techniques used in detecting these drugs of abuse to stay ahead of this growing global drug problem. This review aims to give an overview of known clinical laboratory techniques used in detecting some common drugs of abuse that could serve as an integral part of determining the presence of these drugs in bodily fluids and samples. Relevant literature was reviewed in various search engines (Google Scholar, PubMed, ScienceDirect, Bing). Findings showed that some of the current clinical laboratory techniques for detecting and quantifying drugs of abuse include Microcrystalline tests, thin-layer chromatography, colourimetric tests, immunoassays, urine dipstick tests, and ultraviolet spectroscopy. Apart from these known techniques, new and emerging techniques are being validated to serve as additions to these already existing techniques and be used in clinical settings. In conclusion, the burden of drug abuse is on the rise and becoming a public health concern. There should be an ever-increasing interest in developing new analytical methodologies not only to detect but also to quantify drugs of abuse which may be applied in a plethora of areas including clinical settings.Some of the outlined techniques are highly priced and for cost ineffectiveness, they may be difficult to afford and sustain in resource-restraint settings like developing nations. Hence, grants and laboratory infrastructural support may be needed from international donor agencies.

An audit of adherence to National Cancer Care Programme chemotherapy regimens and prescribing standards in systemic anti-cancer therapy prescriptions in an Irish hospital

Abstract Introduction The availability and usage of systemic anticancer therapy (SACT) has increased significantly over recent years. Whilst SACT has undeniably benefited patients, it also poses a challenge to patient safety as the number of cytotoxic drugs increases. The National Cancer Care Programme (NCCP) has set out to design and implement national policies and practices for oncology medicine in Ireland in order to maintain high levels of patient safety. Aim This study aims to evaluate adherence to NCCP national SACT regimens and prescribing standards at an Irish hospital. Methods This study was a prospective analysis involving an audit of SACT prescriptions for adherence to NCCP regimens and prescribing standards. The study was conducted from June 6th to June 30th 2023; the cohort was defined as patients who were receiving cancer services’ treatment from the medical oncology and haematology department at the hospital. The data collection tool was developed using template in the NCCP Oncology Medication Safety Review Report 2014. A report was run to identify outpatient patients who received SACT on each working day. For inpatients, a daily scheduling Excel file was consulted. Prescriptions were evaluated to complete the data collection tool. Anonymised data was captured and the results were collated to show any trends in adherence to NCCP regimens and prescribing standards. Descriptive analysis of patient and clinical characteristics was performed. Results Pharmacy prescription records of all patients who received SACT during the four-week study period were analysed. A total of 410 SACT prescriptions were reviewed. The median patient age in the study cohort was 59 years (range 23-93 years). Overall, 86.3% of the audited prescriptions adhered to NCCP regimens. The oncology department exhibited a higher adherence rate of adherence to NCCP regimens compared to the haematology department (89.2% versus 82.3%). Melanoma, non-small cell lung cancer, small cell lung cancer, renal cell, prostate, sarcoma, and bladder cancer all had 100% adherence. The lowest adherence rates occurred for CNS (25%), mesothelioma (50%), leukaemia (76.5%), and metastatic colorectal cancer (77.3%). Only 7% of prescriptions were written on pre-printed forms. In this audit, over 98% compliance was observed for eleven of the twenty-four NCCP prescribing standards in the 410 prescriptions: including patient name, patient date of birth, diagnosis, name of supervising consultant, protocol/regimen name, name of drug(s), dose in mg or mg/m2, route of administration, signature of the prescriber and date prescribed. Areas for improvement identified include information about ward/clinic, renal/hepatic function, start date, cycle numbers and medical council numbers. Conclusion This is the first audit of adherence to NCCP regimens using prescription data in Ireland, and the inclusion of 410 samples is a strength; however, the data are from a single site. This study has highlighted areas for improvement in prescribing practices. It emphasises the need for further multidisciplinary team education on adherence to NCCP regimens and prescribing standards. Healthcare professionals should ensure that pre-printed SACT prescription forms are used where available. Additionally, the use of regimen-specific pre-printed forms should be expanded.

Content of medicine prescription and clinical practice training for haematology advanced practice nurses in China: A modified Delphi study

AimTo explore the scope and form of prescriptions for blood and hematopoietic drugs that future advanced practice nurses (APNs) in the Department of Haematology and to establish a medicine prescription training content in China. BackgroundBecause the increasing number of doctors cannot meet the increasing demand for medical care with the population growth, many countries have begun to explore the medical team structure and practice areas, among which nurse prescribing rights have been the most effective. However, China's higher nursing education system still lacks education and training on nurse prescription. DesignOn the basis of literature research and semi-structured interviews, a set of nursing prescription content, education, training and practice system suitable for Chinese nurses was jointly created. MethodsTwo rounds of expert consultation between 23 haematology nursing experts and clinical experts determined the training content of blood system drugs and medicine prescriptions. Additionally, on the basis of the 23 experts，13 experts engaged in clinical and education, teaching and training experts were involved. Two rounds of expert consultation with 36 experts identified a general clinical practice training program for advanced practice nurses in China. ResultsRegarding contents and forms of hematopoietic drugs, the study concluded that advanced practice nurses in haematology department can prescribe anti-anemia drugs, anti-coagulant drugs and anti-thrombotic drugs in 2 categories and 16 drugs. Of these, four kinds of drugs should be prescribed in the form of protocol prescription. One kind of drug should be prescribed in the form of extended prescription and 11 drugs should be prescribed in the form of independent/extended or agreed/extended prescription. Regarding training content, the study obtained the training content of nurses' medicine prescriptions in eight clinical circumstances and the medicine prescription training content for common diseases of the blood system. The required specifications and the medicine prescription decision skills of nurses were sorted out according to different prescription types. ConclusionsThe degrees of expert authority were both higher in consultations. Moreover, the results after consultation were reliable. It was recommended that haematology APNs could prescribe anti-anaemic drugs and anti-coagulation and anti-thrombotic drugs. Furthermore, most drugs should be prescribed in the form of independent/extended or agreed/extended prescriptions. The establishment of a medicine prescription training content for haematology APNs is expected to provide a reference for clinical practice education and training for drug prescriptive authority applicants for blood and hematopoietic system nurses in China.

Dispensing Errors and Self-medication Practices-Pharmacists' Experience in Tabuk: A Cross-sectional Study.

Community pharmacists are engaged in various professional activities starting from drug dispensing to promoting the well-being of patients. They dispense medications as stated in the prescription and are also licensed to prescribe over-the-counter (OTC) medications. Self-medication is widely practiced in various countries, which may lead to irrational drug use. The objectives of this study were to identify the factors associated with dispensing errors, to find ways to minimize dispensing errors, to identify patients' reasons for self-medication, and to find the drugs commonly utilized by patients as OTC medications and the sources of their drug information. A cross-sectional survey of a convenience sample of 286 registered community pharmacists all over Tabuk was conducted using a self-administered questionnaire. Physician's unclear handwriting in the prescription was the major factor for dispensing error (2.6 out of 3) and writing the prescription clearly by the physician or using a printed form of prescription was an important factor in minimizing dispensing errors (2.91 out of 3). Previous similar complaints in the past were the main reason for self-medication (2.45 out of 3) with analgesics and antipyretics being the commonly dispensed drug groups dispensed as OTC medications (2.95 out of 3). Self-medication practices and dispensing errors are widespread in Tabuk. Antibiotics were dispensed as OTC medication, which may lead to more chance of irrational drug use. Writing the prescription clearly and legibly would reduce dispensing errors. It is the community pharmacists' responsibility to increase awareness regarding the appropriate use of drugs to the public.

Menakar Urgensi Kriminalisasi Kepemilikan Harta Tidak Wajar melalui Kebijakan Legislasi dalam Upaya Pemberantasan Tindak Pidana Korupsi di Indonesia

Ownership of inappropriate assets by public officials or named illicit enrichment is still a hot issue. Indonesia itself has a wealth reporting instrument for public officials called the State Officials’ Wealth Report (LHKPN) as a means of controlling and supervising the wealth of public officials. In practice, many public officials have unappropriate assets and are suspected to have been obtained illegally, but these assets cannot be taken by the state because they have not been or have been proven to be the proceeds of criminal act. Thus, this research aims to examine the potential for resolving this problem by criminalizing the ownership of improper assets by public officials, which aims to minimize the incidence of state financial losses. Based on the results of the research, it shows that there are at least two alternative ways, namely (a) making the illegal ownership of public officials whose legality is not proven to be one of the criminal offenses of corruption through the revision of the Corruption Law; or (b) formulate and ratify provisions related to illicit enrichment in the Asset Confiscation Bill. The criminalization of illicit enrichment is a form of implementation of the provisions of Article 20 of the United Nations Convention Against Corruption (UNCAC) as ratified by Indonesia with Law Number 7 of 2006 with the aim of preventing corrupt actions by public officials. This research uses a normative research method with a regulatory-legislative approach and a conceptual approach, the results of which are presented in prescriptive form.

Prevalence of Antibiotic Prescription in Primary Healthcare Settings in the Municipality of Prishtina, Kosovo

Background: Antibiotics remain among the most prescribed drugs in primary healthcare, contributing to increased antibiotic resistance in the community and prevailing as an emerging global health concern. We aimed to quantify the prevalence and quality of antibiotic prescription in primary healthcare settings in the Municipality of Prishtina to identify targets for quality improvement.Methods and Results: This study represents a population-based, retrospective cohort, including data from eight randomly selected family medical centers in the Municipality of Prishtina. Each 150th patient on medical records was assessed for demographic data, diagnosis (ICD-10), antibiotic prescription, antibiotic class, and antibiotic form. In total, the study included 1614 cases reviewed. The antibiotic prescription rate was 16%. The health condition for which most of the cases received antibiotics was J18 - Pneumonia, unspecified organism (67%), followed by J03 - Acute tonsillitis (54%), J42 - Unspecified chronic bronchitis (46%), and N39 - Other disorders of the urinary system (43%) Broad-spectrum antibiotics, such as co-amoxiclav (17.7%), amoxicillin (16.5%), and ceftriaxone (12.6%), featured among the most routinely prescribed antibiotics. The antibiotic prescription rate was the highest for cases in the 3-5 age group, of whom 27% received an antibiotic prescription. In 73% of cases, oral antibiotics were prescribed, 69% of which belong to the WHO AWaRe (Access, Watch, Reserve) essential medicines list. Only 18% of antibiotics were prescribed with their generic names. Conclusion: The prevalence of antibiotic prescription in primary healthcare settings in Prishtina is moderately low. These data cannot be extrapolated to other municipalities in Kosovo or other countries due to different organizational levels. High antibiotic prescription rates for young age groups, prescription of broad-spectrum antibiotics, and high rates of parenteral antibiotics were identified as targets for quality improvement.

Pharmaceutical examination of prescriptions from pharmacy chains of the Republic of Crimea from 2020 to 2021

Introduction. Along with the correct diagnosis of the disease, the stage of choosing the means of pharmacological correction is important, 
 as well as the correct registration of the application to the pharmacy and ensuring the patient’s access to the necessary medication. 
 The purpose of the study is the pharmacological examination of prescription forms received by pharmacy institutions of the Republic of Crimea for the period 2020–2021.
 Materials and methods. The object of the study was a random sample of three hundred thirty two scanned copies of prescription forms 
 No. 148-1/u-04 (L), No. 107-1/u. Additionally, we conducted a survey of pharmacy staff (n = 46). The questionnaire included questions on the analyzed error groups, and also assumed a subjective assessment of the impact of the fact of incorrect prescriptions on the work process. 
 Over the course of the study, methods of analysis, descriptive statistics, comparison, and survey were used.
 Results. The main violations identified in the analyzed prescription forms were incorrect indications of the dosage forms (DF) of the prescribed drugs, as well as inaccuracies in their single and/or daily dosages. In 74 of the received recipes, errors were made when specifying the DF. The study of the frequency of prescribing medication of the certain pharmacological groups allowed determining the largest number of prescriptions to be written for drugs of the anxiolytic group, nootropic drugs, antidepressants. The result of a survey of employees of pharmacy chains revealed to be faced with incorrectly issued prescription forms on a daily basis.
 Limitations. During the pharmaceutical examination of copies of prescription forms received from pharmacy chains of the Republic of Crimea, 322 prescription forms were analyzed, which is a sufficient reference sample.
 Conclusion. When studying individual prescription forms, a sufficient number of various errors were revealed, which may entail a decrease in the quality of medical care for patients on the one hand, and on the other hand, suggests the occurrence of certain difficulties in the work of pharmaceutical workers.

TCM formula for trauma treatment screening and its role of promoting infectious wound coalescence investigating

In pet clinics, the number of cases using trauma drugs accounts for >10% of the total number of cases, and most wounds are healing by second intention. The prolongation of wound healing time causes inconvenience and burden to pets and pet owners. Therefore, how to reduce wound healing time and achieve maximum recovery of tissue function and aesthetics is one of the focuses of veterinary clinical practice. Wound suppuration caused by Staphylococcus aureus and Pseudomonas aeruginosa is the main cause of delaying wound healing. Clinically, available antimicrobial treatments are almost exhausted due to the production of large numbers of resistant bacteria. At present, there are no bacteria resistant to traditional Chinese medicine (TCM), which makes TCM have the potential to become an effective drug for the treatment of bacterial infections, so the use of TCM in the treatment of traumatic infections has broad prospects. Based on the characteristics of infection syndrome, three different prescriptions were formulated in our laboratory, and the most effective prescription and dosage form was screened and named Lianrong Healing Cream (LRHC). The results showed that LRHC regulated the expression of fibroblast growth factor-2 (FGF-2), epidermal growth factor-1 (EGF-1), transforming growth factor-β (TGF-β) and vascular endothelial growth factor-1 (VEGF-1) genes in wound tissues and fibroblasts, thereby accelerating wound healing and repairing wound appearance and function. The results of this study may be help to develop TCM formulation for traumatic infections.

Future curriculum‐makers: The role of professional experience placements as sites of learning about curriculum‐making for preservice teachers

AbstractThe teaching profession and initial teacher education face ongoing pressures which challenge how teachers' work with curriculum is positioned. Within Australia, recent reviews into initial teacher education have emphasised the need for ‘classroom ready’ graduates with knowledge of ‘proven’ pedagogical approaches. Parallel to this has been increasing push for ‘ready‐made’ curriculum materials to be made available to all teachers for their use in classrooms. This discourse espouses curriculum as a product, positioning preservice teachers as future ‘deliverers’ of prescriptive forms of curriculum and dismissing their future potential as classroom curriculum‐makers who engage with curriculum as a process, and think systematically and critically about their curriculum choices. In this paper, we explore the classroom curriculum‐making experiences of two preservice teachers, and the role of professional experience placements as key sites of learning about curriculum‐making, noting this as a significantly under‐researched theme in existing literature. Our in‐depth exploration of these individual cases highlights the contrasting opportunities these teachers had to engage with curriculum as a process, identifying, enabling and constraining structures within these placements which impact on preservice teachers' development, and future potential, as curriculum‐makers. We contend that the pursuit of Lawrence Stenhouse's vision of curriculum work as an iterative, enquiry process driven by and for teachers rests not only on the way in which initial teacher education frames curriculum work in theory, but also in the way it is modelled to preservice teachers during their professional experience placements.

1895 Three-year nationwide analysis of falls risk prescribing for over 65 care home and non-care home patients

Abstract Introduction In 2021 the NHS Business Services Authority Data Science team openly published the first comprehensive nationwide analysis of over 65 care home versus non-care home prescribing (https://nhsbsa-data-analytics.shinyapps.io/estimated-prescribing-patterns-for-care-home-patients/). The analysis has been expanded to include three years of prescribing data and key falls risk prescribing metrics, offering new insight into falls risk prescribing for the over 65s in England. Method Patient address information from 800m prescription forms was matched against 35m Ordnance Survey Address Base addresses. Patient addresses from prescription forms were classified as belonging to a care home or otherwise. Prescribing metrics around volume, cost, polypharmacy and falls risk were generated, with falls risk metrics informed by the STOPPFall study drug groups (https://www.prescqipp.info/umbraco/surface/authorisedmediasurface/index?url=%2fmedia%2f6019%2f300-medication-and-falls-20.pdf). These metrics were the mean number of falls risk medicines and proportion of patients prescribed three or more falls risk medicines within a given month. Results Over 65 care home patients received more prescribing of falls risk drugs than non-care home patients, whilst the proportion of care home patients on three or more falls risk drugs within a given month was double that of non-care home patients. Nearly 40% of care home patients aged 65-69 were prescribed three of more falls risk drugs within a given month, far more than both older care home patients and non-care home patients. Falls risk prescribing metrics displayed a great deal of variation by ICS and Local Authority. Conclusion Aside from headline figures and key findings, the analysis (due for public release in September 2023) allows granular analysis of over 65 falls risk prescribing, by patient age band, gender, geography and care home setting. The exploratory nature of the analysis lends itself to further investigation by healthcare analysts and clinicians, with the aim to gather feedback, iterate and expand the content annually.

Evidence of How Physicians and Their Patients Adopt mHealth Apps in Germany: Exploratory Qualitative Study.

The enactment of the "Act to Improve Healthcare Provision through Digitalisation and Innovation " (Digital Healthcare Act; Digitale-Versorgung-Gesetz [DVG]) in Germany has introduced a paradigm shift in medical practice, allowing physicians to prescribe mobile health (mHealth) apps alongside traditional medications. This transformation imposes a dual responsibility on physicians to acquaint themselves with qualifying apps and align them with patient diagnoses, while requiring patients to adhere to the prescribed app use, similar to pharmaceutical adherence. This transition, particularly challenging for older generations who are less skilled with technology, underscores a significant evolution in Germany's medical landscape. This study aims to investigate physicians' responses to this novel treatment option, their strategies for adapting to this form of prescription, and the willingness of patients to adhere to prescribed mHealth apps. Using an exploratory qualitative study design, we conducted semistructured interviews with 28 physicians and 30 potential patients aged 50 years and older from August 2020 to June 2021. The findings reveal several factors influencing the adoption of mHealth apps, prompting a nuanced understanding of adoption research. Notably, both physicians and patients demonstrated a lack of information regarding mHealth apps and their positive health impacts, contributing to a deficiency in trust. Physicians' self-perceived digital competence and their evaluation of patients' digital proficiency emerge as pivotal factors influencing the prescription of mHealth apps. Our study provides comprehensive insights into the prescription process and the fundamental factors shaping the adoption of mHealth apps in Germany. The identified information gaps on both the physicians' and patients' sides contribute to a trust deficit and hindered digital competence. This research advances the understanding of adoption dynamics regarding digital health technologies and highlights crucial considerations for the successful integration of digital health apps into medical practice.