Life Forms Research Articles

Characterization of low molecular weight sulfur species in seaweed from the Antarctic continent.

Antarctic seaweeds are vital components of polar marine ecosystems, playing a crucial role in nutrient cycling and supporting diverse life forms. The sulfur content in these organisms is particularly interesting due to its implication in biogeochemical processes and potential impacts on local and global environmental systems. In this study, we present a comprehensive characterization of seaweed collected in the Antarctic in terms of their total sulfur content and its distribution among different classes of species, including thiols, using various methods and high-sensitivity techniques. The data presented in this paper are unprecedented in the scientific literature. These methods allowed for the determination of total sulfur content and the distribution of sulfur compounds in different fractions, such as water-soluble and proteins, as well as the speciation of sulfur compounds in these fractions, providing valuable insights into the chemical composition of these unique marine organisms. Our results revealed that the total sulfur concentration in Antarctic seaweeds varied widely across different species, ranging from 5.5 to 56gkg-1 dry weight. Furthermore, our investigation into the sulfur speciation revealed the presence of various sulfur compounds, including sulfate, and some thiols, which were quantified in all ten seaweed species evaluated. The concentration of these individual sulfur species also displayed considerable variability among the studied seaweeds. This study provides the first in-depth examination of total sulfur content and sulfur speciation in brown and red Antarctic seaweeds.

In silico prediction of heme binding in proteins

The process of heme binding to a protein is prevalent in almost all forms of life to control many important biological properties, such as O2-binding, electron transfer, gas sensing or to build catalytic power. In these cases, heme typically binds tightly (irreversibly) to a protein in a discrete heme binding pocket, with one or two heme ligands provided most commonly to the heme iron by His, Cys or Tyr residues. Heme binding can also be used as a regulatory mechanism, for example in transcriptional regulation or ion channel control. When used as a regulator, heme binds more weakly, with different heme ligations and without the need for a discrete heme pocket. This makes characterisation of heme regulatory proteins difficult, and new approaches are needed to predict and understand the heme-protein interactions. We apply a modified version of the ProFunc bioinformatics tool to identify heme binding sites in a test set of heme-dependent regulatory proteins taken from the Protein Data Bank (PDB) and AlphaFold models. The potential heme binding sites identified can be easily visualised in PyMol and, if necessary, optimised with RosettaDOCK. We demonstrate that the methodology can be used to identify heme binding sites in proteins, including in cases where there is no crystal structure available, but the methodology is more accurate when the quality of the structural information is high. The ProFunc tool, with the modification used in this work, is publicly available at https://www.ebi.ac.uk/thornton-srv/databases/profunc and can be readily adopted for the examination of new heme binding targets.

Identifying and Check Names of Wild Plants from Brassicaceae Family in Western Desert District of Iraq

Several field trips were carried out in the winter and spring of 2019 and 2023 in Western Desert District of Iraq, resulting in the collection and identification of more than 490 plant samples from the Brassicaceae family. The total number of species reached 48 species belonging to 35 genera. Among them is the new species Morettia parviflora Boiss., which is recorded for the first time in Iraq. In addition to recording a new presence of five species in this District, namely: Camelina hispida Boiss., Glastoria glastifolia (DC.) O. ktze., Lepidium latifolium L., Sinapis alba L. and Sterigmostemum Sulphureum (Banks) Bornm. scientific names were checked, and this study worked to adopt internationally accepted names, it was arranged in tables that included the first publication, habitat, duration and life form, note that the largest percentage of species were annual herbs (40 Species, 83%), and the life form (Therophytes) had the highest percentage (37 species, 77%). A map was prepared for the distribution of the new species in the district and the country. The species M. parviflora was also treated taxonomically, some plant samples were deposited in Iraqi National Herbarium with the numbers 68314, 68315, 68316 and 68317.

Current Status of Potential Antiviral Drugs Derived from Plant, Marine, and Microbial Sources

Abstract: Natural substances have been the principal source of medications since antiquity. Natural goods are gaining popularity as a source of novel medications. This article investigates a variety of variables like plant, marine, and microbial sources that contribute to the growing interest in natural goods as a source of novel medications. Viruses have remained resistant to treatment and prevention for a longer period than other forms of life. Viral diseases can currently only be treated with a limited number of drugs. Significant research initiatives have been committed to identifying novel antiviral natural compounds to fight viruses that harm people, plants, insects, animals, fungi, and microbes. A recent study of the prevalence and sources of antiviral medications licensed by the Food and Drug Administration (FDA) has focused on natural products. Out of the estimated 250,000 higher plant species, only 5 to 15 percent have been thoroughly evaluated for the existence of bioactive substances in them, and the ability of the other species has hardly been investigated. This review aims to offer an overview of the crucial role played by natural products in the discovery and development of novel antiviral drugs with potent antiviral activity, including phytochemicals such as carbohydrates, coumarins, flavonoids, chromones, alkaloids, lignans, phenols, tannins, proteins, peptides, antiviral plant extracts, other marine, and microbial sources.

«Normality was the problem!» Femminismi e Commoning nella riproduzione sociale della città

The research is part of the intense relationship between feminisms and commoning, with the general aim of reflecting on the real and potential role of women in the experiences of mutualism that nourish forms of collective life and paths of re-appropriation of spaces, practices and rights in urban scenarios. A gendered vision is consistent with the theoretical foundations of commoning, a phenomenon perceived as an alternative to individualism and capitalist isolation, insofar as it is capable of giving voice to a new debate on a fairer and more effective management of resources and spaces. Through a critical reading of the literature on social reproduction, a vision of common reproduction is proposed with the ultimate aim of contributing to the debate on the need to generate new theories and urban models more consistent with current social challenges.

Data collection for assessment of the natural capital at the regional level: case study of LTSER Trnava region

ContextThe landscape provides not only a living space for all life forms, including humans, but also a spatial base and set of resources for the implementation of individual human activities. Inappropriate implementation of human activities, disrespecting the properties of the landscape's natural resources, causes the degradation of natural resources and, consequently, the human living.ObjectivesThe aim of this paper is to develop new methodological procedures and algorithms for effective assessment of natural capital based on the geosystem approach.MethodsEach territorial unit (geosystem) represents a unique combination of natural assets that create a certain potential for the development of individual activities and eco-stabilization functions. In this study, we developed a new approach and algorithms to assess the natural capital of landscapes for sustainable use. This involves selecting indicators and their functional interpretation, as well as collecting available spatial data and statistics for GIS analysis, synthesis, and modeling.ResultsThe methodological procedure consists of the determination of indicators for natural capital assessment, the determination of their functional values and weighting coefficients, the determination of the suitability of the geosystem for the implementation of individual activities based on the value of natural capital, and the determination of restrictions and limiting factors. The set of data on landscape assets can be categorized into abiotic, land cover and biotic, and socio-economic indicators, which can either support human activities or limit them. Options for sustainable use of natural capital were split into two groups of potential activities: (I) natural capital for landscape planning activities and (II) specific activities or functions (e.g., natural capital for energy use, recreation, regulation services). The modeling of eco-stabilizing natural capital in Trnava LTSER pointed to low spatial ecological stability, mainly in the central part of the district.DiscussionDiscussion pointed to strength, novelty and opportunities of implementing methodological approach to natural capital assessment.ConclusionsAs an output of this methodological approach, a comprehensive digital spatial database of landscape-ecological data for the assessment of natural capital and the suitability of its use for socio-economic activities has been created in Slovakia. The database represents a set of consistent spatial information on natural capital assets and other indicators, including land cover and socio-ecological indicators. The methodological approach can be applicable to any territory on the basis of a modification.

Methodological notes for decolonizing dignity in the common goods’ configuration of justice

In the current wave of movements advocating for the protection of the Commons in the Global South, this article asserts that the attainment of human dignity is inherently tied to acknowledging the dignity of all life forms, a concept termed as “the-more-than-human”. The article presents a dual argument. Firstly, it contends that without recognizing the dignity of all life, genuine human dignity remains unachievable. Secondly, it calls for the decolonization of the philosophical foundations that prioritize a singular model of dignity for humanity. Consequently, the article emphasizes the necessity of acknowledging multiple dignities to effectively safeguard the Commons from both legal and philosophical perspectives. It argues that prevailing philosophical frameworks of human dignity present obstacles to the protection of the Commons hence it advocates for their reevaluation and restructuring.

Targeting glutamate metabolism in chronic lung diseases

AbstractAmino acids are necessary for all life forms, which play various roles. Disorder of amino acid metabolism is now considered an important driving mechanism in diverse pulmonary conditions, particularly chronic lung diseases like chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and lung cancer. Glutamate actively participates in multiple vital biological processes, while the intricate glutamate metabolism, glutamate receptors and glutamate transporters assume crucial regulatory functions in the development of chronic lung diseases. This review aims to discuss the relationship between glutamate dysfunction and chronic lung diseases. By discussing the physiological and pathological function of glutamate, we probe the potential drug targets for chronic lung diseases in the glutamate pathway.

Membranes on the move: The functional role of the extracellular vesicle membrane for contact-dependent cellular signalling.

Extracellular vesicles (EVs), lipid-enclosed structures released by virtually all life forms, have gained significant attention due to their role in intercellular and interorganismal communication. Despite their recognized importance in disease processes and therapeutic applications, fundamental questions about their primary function remain. Here, we propose a different perspective on the primary function of EVs, arguing that they serve as essential elements providing membrane area for long-distance, contact-dependent cellular communication based on protein-protein interaction. While EVs have been recognized as carriers of genetic information, additional unique advantages that they could provide for cellular communication remain unclear. Here, we introduce the concept that the substantial membrane area provided by EVs allows for membrane contact-dependent interactions that could be central to their function. This membrane area enables the lateral diffusion and sorting of membrane ligands like proteins, polysaccharides or lipids in two dimensions, promoting avidity-driven effects and assembly of co-stimulatory architectures at the EV-cell interface. The concept of vesicle-induced receptor sequestration (VIRS), for example, describes how EVs confine and focus receptors at the EV contact site, promoting a dense local concentration of receptors into signalosomes. This process can increase the signalling strength of EV-presented ligands by 10-1000-fold compared to their soluble counterparts. The speculations in this perspective advance our understanding of EV-biology and have critical implications for EV-based applications and therapeutics. We suggest a shift in perspective from viewing EVs merely as transporters of relevant nucleic acids and proteins to considering their unique biophysical properties as presentation platforms for long-distance, contact-dependent signalling. We therefore highlight the functional role of the EV membrane rather than their content. We further discuss how this signalling mechanism might be exploited by virus-transformed or cancer cells to enhance immune-evasive mechanisms.

Contrasting resistance and resilience trajectories of zooplankton communities in restored fishless alpine lakes

AbstractCatastrophic state changes often occur in ecosystems as consequences of shifts in the dominant life forms, such as in the case of sportfish introduction into naturally fishless mountain lakes. While the pronounced ecological displacement of native communities by these novel predators (i.e., weak resistance) is well documented, few studies have also examined the dynamics of their recovery rates (i.e., “engineering resilience”) following stressor removal. We addressed this knowledge gap by quantifying the taxonomic and species trait‐based ordination trajectories of crustacean zooplankton communities in stocked alpine lakes, which differed in how they were restored to a natural fishless state over a period of six decades. Resilience and resistance trajectories differed in each lake as the ecological importance of trait‐based species recolonization potential (e.g., asexual vs. sexual reproduction) replaced that of tolerance of size‐selective predation by fish (e.g., body size, pigmentation, motility). As a result, re‐establishment of large‐bodied zooplankton following the elimination of fish restored annual secondary production. In contrast, a more gradual unidirectional ordination trajectory toward smaller zooplankton body size and a decline in total zooplankton biomass occurred in a nearby alpine lake containing a protected native bull trout population. Although recovery trajectories returned via routes that differed from those of earlier resistance trajectories (i.e., hysteresis), we discovered that full taxonomic and functional recovery was realized in all the restored fishless lakes within three decades, regardless of the approach used to achieve ecosystem restoration.

New Benthic Fossils from the Late Ediacaran Strata of Southwestern China

AbstractThe Jiangchuan Biota from the Jiucheng Member (Mb.) of the Dengying Formation (Fm.), discovered in Jiangchuan, eastern Yunnan, China, is marked by copious macrofossils at the apex of the Ediacaran strata. This fauna features benthic algae with varied holdfasts and other fossils of indeterminate taxonomic affinity and is compositionally unique compared to the Shibantan and Gaojiashan biotas of the Dengying Fm. and the Miaohe and Wenghui biotas of the Doushantuo Fm., elsewhere in China. One novel benthic saccular macroalgal fossil, named here Houjiashania yuxiensis gen. and sp. nov., from the Jiangchuan Biota is based on fossils that are sausage‐shaped, elongate, tubular, ranging from 0.3 to 4 cm in length, and up to 0.8 cm in diameter. One terminus is blunt and rounded to an obtuse angle, the other is bent with a spread‐out surface resembling a holdfast, suggesting a three‐dimensional thallus. Thin, stipe‐shaped outgrowths, likely vestiges of sessile saccular life forms, are prevalent in macroalgal fossils of analogous size and shape, as well as present brown algae Scytosiphonaceae, such as Colpomenia and Dactylosiphon. The new findings augment the diversity of benthic algae, such as those known from the Early Neoproterozoic Longfengshan Biota in North China. The benthic algal macrofossils in the Jiucheng Mb. add to knowledge of Late Ediacaran metaphyte diversification and offer more clues about the evolutionary positioning of primitive macroalgae. The co‐occurrence of numerous planktonic and benthic multicellular algae and planktonic microbes might have facilitated ecologically the more extensive later Cambrian explosion evidenced by the Chengjiang Biota in Yunnan.

FLORISTIC COMPOSITION, LIFE-FORMS AND CHOROLOGY OF AL-MADLOOM MOUNTAIN, ADHALE DISTRICT, SOUTHERN YEMEN

The floristic composition, life form, and chorology were conducted in Al-Madloom mountain, Adhale, South of Yemen. The flora consisted of 159 plant species belonging to 111 genera and 46 families. Apocynaceae (12 genera; 19 species), Euphorbiaceae (eight genera; 14 species), and Acanthaceae (eight genera; 8 species) were the most dominant families in terms of species richness. The plants were classified into different life forms and Chorotypes after standard methods. Among the life forms, Chamaephytes 60 species (37.73%) were the dominant followed by Therophytes 47 species (29.55%), Phanerophytes 29 species (18.23%), Geophytes 15 species (9.43%), Hemicryptophytes six species (3.77%), while two species were Parasites (1.25%). From the Chorological point of view, the study revealed that the highest number of species 56 (35.22%) was recorded in the Su-Za Chorotype, followed by Cosmopolitan 20 species (12.57%), Endemic 18 species (11.32%) and ZU-ZA+SA-SI 16 species (10.06%). The Sudano-Zambenzian constitute 56 species, which means the flora of the study area belongs to the Sudanian region. The domination of Chamaephytes and Therophytes indicates that the investigated area is under deep biotic stress. Endemism in the study area is relatively significant, represented by 11.32% of the total flora collected from the study area, and these taxa were listed to be globally endangered.

Climate and soil properties regulate the initial concentrations of potassium, calcium and magnesium in plant litter on a global scale

Abstract The initial concentration of litter nutrient not only affects the following decomposition process but also determines the quantities of nutrients returned to the soil. The aim of this study is to assess the global patterns and driving factors of three macronutrients, namely potassium (K), calcium (Ca) and magnesium (Mg), in freshly fallen litter. By synthesizing 5861 data points extracted from 584 publications, we quantitatively evaluated the concentrations of litter K, Ca and Mg in different litter types, life forms, taxonomic divisions and mycorrhizal associations. Also, using the machine learning method, we predicted their global patterns in forests, grasslands and shrublands. We found that (1) mean K, Ca and Mg concentrations ranged from 2.63 to 6.23, 1.05 to 11.50 and 0.20 to 2.74 g/kg, respectively, across different litter types; (2) the initial nutrients of the litter were significantly affected by plant functional types (e.g. life form, taxonomic division and mycorrhizal association), climate (e.g. isothermality, mean diurnal range, annual evapotranspiration and precipitation seasonality) and soil properties (e.g. pH, exchangeable Ca concentration and water content), with a higher litter K concentration of herbaceous plants, higher K, Ca and Mg concentrations from angiosperms and higher K and Mg concentrations from plants associated with arbuscular mycorrhiza (AM) fungi; and (3) the predicted leaf litter K, Ca and Mg concentrations were lower in high‐latitude regions compared with those in low‐ and/or mid‐latitude regions. Our study provides a globally comprehensive analysis on the patterns and driving factors of three important macronutrients in freshly fallen litter, contributing to a better understanding of their role in the decomposition process of litter, as well as the associated biogeochemical cycles under the future climate change scenario. Read the free Plain Language Summary for this article on the Journal blog.

Measurement System for Compliance in Tubular Structures

Tubular structures such as blood vessels, intestines, and the trachea are common in various life forms. This paper describes a measurement system to test the mechanical compliance of tubular structures. The novelty of the system lies in its hardware and software. Here we use vascular graft as an example to demonstrate the utility of the system. A fully synthetic vascular graft would ideally mimic the mechanical and architectural properties of a native blood vessel. Therefore, mechanical testing of the graft material under physiological pressure is crucial to characterizing its potential in vivo performance. The device operates through a low-cost Arduino-based control system that simulates and measures cyclic fluid pressure changes over time and a laser micrometer that measures diameter changes with pressure. This system is low-cost, assuming one already has access to a laser micrometer. In contrast to previous methods, this system offers a simple, low-cost, and customizable option to measure compliance and is equipped with data acquisition/analysis programs. These programs include a MATLAB application that processes and synchronizes Arduino Uno pressure signals and LabChart Pro diameter readings. Lastly, this paper explains the hardware and software of the measurement system. The system is beneficial for testing the pressure-diameter relationship of tubular structures of varying sizes and materials. KEYWORDS: Tubular Structures; Compliance; Data Acquisition System; Physiological Pressure; Diameter Change; Arduino Uno; LabChart Pro; MATLAB

Bioremediation of Sulfate in Water Environment: An Overview of Removal Pathways and Influencing Factors

Sulfate-laden wastewater generated from various natural and industrial activities, including mining, metallurgy, electroplating, and battery manufacturing and recycling, has the potential to contaminate both ground and surface water bodies. It is harmful to all forms of life and the environment. Thus, developing an efficient treatment system to address sulfate pollution is necessary. Biological sulfate reduction (BSR) involving sulfate-reducing bacteria offers a better removal of sulfate than conventional physicochemical methods. BSR offers various advantageous such as lower sludge production, removal and recovery of metals, and production of elemental sulfur. However, the performance of bioreactors depends on wastewater sources, microbes involved, and operating conditions. Currently, limited studies are available encapsulating the current state of the art of biological sulfate remediation aimed at optimization of bioreactor design and operation. Therefore, this paper attempts to provide a comprehensive review of the sources of sulfate, its health and ecological effects, microbes involved in sulfate reduction, and its removal pathways that would be beneficial for future bioreactor design. In addition, theoretical and practical aspects of influencing factors have been discussed. Considering the results of the reviewed articles, operating, and set-up conditions are recommended to obtain the higher sulfate removal. It includes dissimilatory sulfate reduction by mixed bacterial culture using sodium lactate as an electron donor with pH near about neutral, mesophilic conditions, COD/SO2−4 ratio of 0.67-1.7, ORP less than −100 mV, and lesser sulfide concentration. This overview helps to develop an effective strategy for bioremediation of sulfate and decreasing the sulfate-rich industrial effluent footprint.

2011–2015年洞庭湖洲滩群落植物生态型、生活型和生长型组成数据集

Analyzing plant life-forms and ecotypes can provide deep insights into the relationship between plant community structure and environmental conditions, and plant life-forms play an important role in understanding the emergence, development, and succession laws of plant community. An investigation was made on the species life-forms and ecotypes of wetland plants in Dongting lake wetland. In accordance with the unified monitoring specifications of the Chinese Ecosystem Research Network (CERN), the Dongting Lake Wetland Ecosystem Observation and Research Station conducts long-term positioning monitoring on the species composition, species life-forms, growth forms and ecotypes of typical beach vegetation in the wetland ecosystem in response to the changing hydrological conditions of Dongting Lake. The dataset of long-term monitoring conducted on three typical plant communities (Carex sp., Miscanthus lutarioriparius and Polygonum hydropiper) in Dongting Lake wetland has been verified by experts to ensure the accuracy of the data. We then classified and processed the data to obtain the dataset of community composition of plant life-forms, growth forms and ecotypes on Dongting Lake beach (2011–2015). The dataset covers a total of 8 indicators, namely species name, Latin name, life-form, growth form, ecotype according to light intensity, ecotype according to water requirement, ecotype based on soil pH and ecotype according to responses sediment burial. This dataset comes with detailed background information to ensure its consistency across both spatial and temporal dimensions. This dataset comes with detailed background information about site information and site management records to ensure its consistency across both spatial and temporal dimensions. This dataset can provide support for the analysis of the classification of plant life forms and the composition and structure of ecotypes, and serve as valuable reference for further study of vegetation succession in Dongting Lake wetland.

Oppressive Forms of Life

ABSTRACT Rahel Jaeggi argues that forms of life ought to be the main reference point for a critical theory of society because the internal normative structure of life forms allows for immanent critique. In this article, I extend her model by systematically considering the possibility of oppressive forms of life. Oppressive forms of life are clusters of practices in which subordinated groups are systematically excluded or disabled from participating in the social processes of interpretation through which the values and purposes of those very practices are determined. The possibility of oppressive forms of life poses a challenge to the method of immanent critique because it seems that any such critique must rely on immanent norms that are at least partly constituted by interpretations and that can therefore be distorted by oppression. I argue that Jaeggi’s model of immanent critique can be extended to respond to that challenge, either by recovering a constitutive form of freedom within all forms of life or by consciously adopting a partisan stance in favour of oppressed and marginalised self-understandings.

돈의 사회적 가치와 의미 탐색

The aim of this story is to represent through novel writing the way financial subjects of different generations give social value and meaning to money based on financial education at home. The research results are briefly presented as follows. The main characters in the novel used money in different ways depending on the socioeconomic conditions and context of their lives, and the social meaning and value assigned to money was also different. However, despite the three generations in the novel having different values and meanings surrounding the use of money, they each showed similarities in seeking liberation from labour and money in their own way. Ultimately, the social meaning and value attached to the use of money changed depending on socioeconomic and historical conditions and the context of individual life. However, money was a social apparatus and mechanism that realized the individual’s self through liberation from labour and money itself and expressed the way and form of life. This story will contribute to elucidating and expanding the social value and meaning of money by describing the financial behavior and financial attitudes of three generations of financial subjects differently handling money. In addition, the results of this story shed light on personal and social conflicts surrounding money and well-being by exploring the social values and meanings of the use of money in different generations, and help financial subjects make wise financial decisions and manage their finances in financial capitalism.

Iron deficiency anemia in hospitalized children

Iron is an abundant element on earth. It is used by nearly all forms of life from micro-organisms to humans for their developmental and survival as it is part of many enzymes involved in biological processes such as DNA synthesis, oxygen transport, and cellular energy production. Anemia is the most widely recognized manifestation of iron deficiency. This study was conducted to estimate the prevalence of iron deficiency anemia, based on age, in 200 hospitalized children 0-14 years old. Hemoglobin <12g/dL was found in 54.5% of children, 69% of the children 0-2years old had Hb<12g/dL, 51% of the children 2-6years old had Hb<12g/dL, and 19% of the children 6-14years old had Hb<12g/dL. In conclusion iron deficiency anemia is prevalent in hospitalized children, infants are the group mostly affected. Iron deficiency anemia is a major health concern as it increases risk of child morbidity, impairs cognitive and physical developmental in children and reduces school performance. It is an easily treated medical condition with excellent outcome, so a meticulous clinical attention and evaluation should be kept for children of any age.

Streptococcus thermophilus: A Source of Postbiotics Displaying Anti-Inflammatory Effects in THP 1 Macrophages.

In addition to traditional use in fermented dairy products, S. thermophilus also exhibits anti-inflammatory properties both in live and heat-inactivated form. Recent studies have highlighted that some hydrolysates from surface proteins of S. thermophilus could be responsible partially for overall anti-inflammatory activity of this bacterium. It was hypothesized that anti-inflammatory activity could also be attributed to peptides resulting from the digestion of intracellular proteins of S. thermophilus. Therefore, total intracellular proteins (TIP) from two phenotypically different strains, LMD-9 and CNRZ-21N, were recovered by sonication followed by ammonium sulphate precipitation. The molecular masses of the TIP of both strains were very close to each other as observed by SDS-PAGE. The TIP were fractionated by size exclusion fast protein liquid chromatography to obtain a 3-10 kDa intracellular protein (IP) fraction, which was then hydrolysed with pancreatic enzyme preparation, Corolase PP. The hydrolysed IP fraction from each strain exhibited anti-inflammatory activity by modulating pro-inflammatory mediators, particularly IL-1β in LPS-stimulated THP-1 macrophages. However, a decrease in IL-8 secretion was only observed with hydrolysed IP fraction from CNRZ-21N, indicating that strain could be an important parameter in obtaining active hydrolysates. Results showed that peptides from the 3-10 kDa IP fraction of S. thermophilus could therefore be considered as postbiotics with potential beneficial effects on human health. Thus, it can be used as a promising bioactive ingredient for the development of functional foods to prevent low-grade inflammation.