Diverse Forms Research Articles

Causal relationship between allergic rhinitis and otitis media: A Mendelian randomization study.

Otitis media and allergic rhinitis are prevalent conditions. Some data posit a significant association between the 2 ailments, proposing mechanisms such as allergic rhinitis-induced Eustachian tube dysfunction or concurrent allergic pathophysiology affecting both the nasal and aural cavities. Observational studies hint at an association between allergic rhinitis (AR) and nonsuppurative otitis media, yet definitive causality remains elusive. Thus, to elucidate the causal impact of AR on otitis media, a 2-sample Mendelian randomization study was undertaken. Data on AR, acute suppurative otitis media, chronic suppurative otitis media, and nonsuppurative otitis media were sourced from the Genome for Extensive Association Study, encompassing individuals of European ancestry. Single nucleotide polymorphisms linked with AR were utilized as instrumental variables. The inverse-variance weighting (IVW) method, alongside sensitivity analyses employing the weighted median and Mendelian randomization-Egger methods, was employed to assess causal effects. Our analysis revealed a significant causal effect of AR on nonsuppurative otitis media (IVW, odds ratio [OR] = 12.22, 95% confidence interval, 1.38-107.93, P = .024) and indicated an association with acute suppurative otitis media (IVW, OR = 6.95, 95% confidence interval, 0.80-60.35, P = .078). However, no causal effect of AR on chronic suppurative otitis media was discerned. Our findings delineate a measurable causal link between AR and nonsuppurative otitis media (OR = 12.22) and suggest an association with acute suppurative otitis media (OR = 6.95), though lacking evidence for a causal effect on chronic suppurative otitis media. These results underscore the propensity of AR to correlate with diverse forms of otitis media and furnish high-quality causal evidence pertinent to clinical management.

Correlation of Neuroinflammation and Therapeutic Targets in Perioperative Neurocognitive Disorders.

Perioperative Neurocognitive (PND) disorders represent a prevalent complication among geriatric patients, manifested in diverse forms of cognitive impairment following anesthesia and surgical procedures. Even though the exact origin of PND disorders is still unknown, neuroinflammation has been identified as a significant contributing factor, particularly in older patients. Hence, this review aims to provide a deeper insight into the underlying mechanism and associated potent therapeutic targets for the efficient management of perioperative neurocognitive disorders. Many factors, such as PRRs, chemokine receptors, immunoglobulin superfamily receptors, and purinergic receptors, are involved in the development and occurrence of perioperative neurocognitive disorders to varying degrees and may be valuable biomarkers for their effective management. Here, we present a comprehensive overview of the involvement of neuroinflammation in PND disorders, including their onset and possible therapeutic targets. This review would benefit future researchers in elucidating a better therapeutic approach for the management of perioperative neurocognitive disorders. We have also briefly outlined the clinical trials associated with Postoperative neurocognitive disorders in the last section of the review. Altogether, this review would help the researchers investigate better therapeutics for the management of PND disorders.

Examining longitudinal changes in citation practices

Abstract While previous research has revealed the form and function features of citations across diverse disciplines, writer groups of varying expertise, and academic genres, limited attention has been given to the developmental trajectories in citation practices among novice academic writers. To address this issue, we conducted a corpus-based, discipline-specific analysis of the citation practices of L2 English novice academic writers over time. Using a multi-perspective analytical approach, we examined citation types and functions, along with reporting verbs and reporting structures in 39 linguistics course papers written by 13 L2 English undergraduate students across three semesters. Overall, we observed an increase in citation density, with more diverse citation forms and functions, as well as an expanding usage of reporting verbs and structures. Our results shed light on the developmental trajectory of citation practices and the persistent challenges for novice academic writers. Implications for English for Academic Purposes pedagogy are discussed.

Expanding infrastructure ontologies: Integrative and critical insights for coastal studies and governance

Diverse knowledge insights are essential to inform action on bringing about transformations in how societies live with changing Earth, ocean and coastal systems. However, knowledge forms typically used in governance systems are stubbornly limited. This paper analyzes the extent to which an expanding ontology of the concept of ‘infrastructure’ can contribute to building more integrated knowledge for governance in ocean and coastal contexts. This paper asks: What can creative and critical engagement with infrastructure thinking offer to efforts to bring together diverse forms of knowledge and to develop more effective and ethical governance in changing coastal contexts? Employing a qualitative assessment of how the concept of infrastructure is defined in multiple disciplines and contexts, the paper identifies three heuristic types of structures, things and processes that can collectively inform interdisciplinary dialogue and governance dialogue: (i) built/physical infrastructure, (ii) environmental infrastructure, and (iii) societal/cultural infrastructure. Drawing on insights from critical infrastructure studies and more-than-human perspectives, the paper then identifies ontological and methodological challenges of integration, values, and power/agency for those who engage a multi-faceted conception of infrastructure to frame analysis and action. Bringing these insights together, the paper argues that infrastructure thinking provides a means to facilitate interdisciplinary dialogue, and a useful lens with which to analytically integrate diverse forms of knowledge about/in ocean and coastal contexts. However, cautious and critical perspectives are needed to support efforts in (re)thinking and integrating for collective action and governance.

Nonanthropocentric climate ethics

AbstractAnthropogenic climate change poses increasingly severe long‐term threats to living things worldwide. It may even contribute to a mass extinction that would leave biodiversity depleted for millions of years—quite possibly longer than the duration of the human species. Such effects are obviously of ethical concern, but because traditional ethical theories have focused on the relatively short‐term interests of human beings, they offer little guidance. In the late 20th century, a growing number of ethical activists and theorists sought to expand moral consideration to nonhuman animals and to the diverse life forms and habitats of wild nature. Simultaneously and at first independently, others began to develop long‐term (sometimes called “intergenerational”) ethics, which extends moral consideration into the distant future. Concerns about future climate change quickly became a central focus of this work. But only in this century have there been concerted efforts to integrate these lines of thought into far‐sighted nonanthropocentric climate ethics. These efforts are the subject of this review.This article is categorized under: Climate, Nature, and Ethics > Ethics and Climate Change Integrated Assessment of Climate Change > Assessing Climate Change in the Context of Other Issues Climate, Nature, and Ethics > Comparative Environmental Values

Conventional and Modern Techniques to Treat Cancer

Cancer is global health problem responsible for one in six deaths worldwide. Treating cancer has been a highly complex process. Based on common belief, herbal medicine with the least possible side effect should be the centre of attention in cancer care. Cancer remains one of the most formidable challenges in modern medicine, with diverse forms and intricate mechanisms of progression. Cancer is a complex and multifaceted group of diseases characterized by the uncontrolled growth and spread of abnormal cells. This abstract provides a broad overview of various cancer types, highlighting their prevalence, risk factors, diagnostic methods, and treatment options. The main objective of cancer treatment is – How to discover? How to detect? How to prevent? How to treat? There are various herbal drugs that are used to treat cancer. Some mentioned drugs are as follows- curcumin, astragalus, wheat grass, green tea, garlic and ashwagandha, cinnamon and zinger etc… The most widely used traditional treatment methods are surgery chemotherapy and radiotherapy while modern modalities includes hormone therapy, targeted cell therapy, steam cell therapies, immunotherapies, radiation therapies, and antioxidants drugs. As we known some modern techniques are also used in treatment in cancer such as – Nano medicine, nano therapy, liquid biopsies and gene editing.

Review on different Multimodal Approaches for Multifactorial Cancer Disease

In early-stage cancer, chemotherapy, radiotherapy or surgery is a common treatment. However, monotherapy results in medicine struggle besides later numerous series of treatment; it loses its effect in patients. The multimodal approach is an elementary principle for treating maximum tumor categories by confirmed existence benefits. The multidisciplinary approach comprises multimodality action and surgery followed by radiotherapy with or lacking chemotherapy or simultaneous chemoradiotherapy is mandatory for diverse forms of tumor. In all pathological states including cancer, combination approach is considered as future of therapeutics. Thus, grouping of multidrug treatment is utmost frequently utilized strategy in cancer treatment. While combining cancer treatment together with anticancer drugs overcomes the medicine fighting as well as provides synergistic result displaying delayed existence for patients. The drive of present review article is to 1) climax necessity and importance of multidisciplinary method in cancer treatment; 2) discuss part of radiotherapy, chemotherapy, immunotherapy and their combinations.

Understanding dental practitioners' knowledge and practices of smokeless tobacco: South Texas Oral Health Network study

ObjectiveThis study, conducted by the South Texas Oral Health Network, evaluated dental practitioners' knowledge, attitudes, and practice behaviors regarding cultural forms of smokeless tobacco (SLT) use and effects, using the 5As (Ask, Advise, Assess, Assist, and Arrange) framework. MethodsChi-squared tests examined associations between dental practitioners’ characteristics, self-confidence, knowledge, attitudes, and practices. The 5As tobacco cessation intervention steps were analyzed using the Wilcoxon rank sum test to measure changes in the frequency of use between successive steps. ResultsThe study finds that higher knowledge scores about SLT forms (chewing tobacco, snuff, dip, paan, betel quid, gutka areca nut) were linked to greater adherence to the Assess and Assist of the 5As cessation intervention steps. However, adherence rates to the 5As declined progressively from Ask to Arrange, representing a gap in SLT cessation practice among active dental practitioners. Dental practitioners were found to be more familiar with conventional SLT forms (e.g., snuff) and less with cultural SLT forms (e.g., paan). ConclusionThese findings underscore the need for improved culturally relevant training to enhance practitioner awareness concerning cultural SLT forms and increase progression through the 5As cessation intervention. Practice implicationsWe anticipate that our findings will highlight the critical need for dental practitioners to be aware of diverse cultural forms of SLT and their associated oral and systemic effects to support cessation efforts effectively, primarily due to the growth of culturally diverse communities in the United States and the corresponding rise in the use of previously unrecognized forms of SLT in dental practices. This study is designed to understand the cultural nuances the practitioner needs to develop and communicate the health hazards and importance of cessation of SLT use in the immigrant and refugee populations. Clinical significanceThis study is significant because it highlights the importance of understanding diverse cultural forms of SLT and cessation practices among dental practitioners. Understanding this will enhance awareness and guide training to improve SLT cessation efforts, improve oral health outcomes, and address disparities in diverse patient populations, particularly amidst increasing immigration trends.

Gross to gourmet: A social media analysis of Naked Clams as a sustainable delicacy

AbstractAmidst a global food crisis, securing sustainable food sources is vital. Bivalves such as Naked Clams, historically known as shipworms, offer a promising solution due to their low environmental impact, high nutritional value, and rapid growth rates. Contrary to their image as pests, Naked Clams are the fastest growing bivalves and have various health benefits. Believed to be the world's first aquaculture species, cultivated by Aboriginal Australians 8000 years ago, they are a delicacy in Southeast Asia. Public perception of Naked Clams remains largely unexplored, hindered by their association as pests and worm‐like appearance. This study assesses the perception of Naked Clams through social media, analyzing 40 posts across Facebook, Instagram, TikTok, and YouTube, with millions of views and likes. Analysis of nearly 8000 comments revealed that public perception was split, though generally more positive than negative. Concerns included appearance, potential religious dietary conflicts, and the risk of parasites, which can be addressed with educational campaigns. Importantly, 84% of commenters who tried Naked Clams reported liking them. Naked Clams are noted for their high protein content, nutrient density, and health benefits, and are enjoyed in diverse culinary forms, from traditional raw dishes, to battered calamari‐style street foods, to innovative recipes like Naked Clam ice cream. This study highlights the untapped potential of Naked Clams in global diets and calls for further exploration into moving Naked Clams from “gross to gourmet.”

Storying connectivity and value: the south west creative technology network’s cultural ecologies as network visualisations

ABSTRACT This paper explores the productive connectivity developed by university-industry knowledge exchange (KE) programmes for research and development (R&D) and their emergent cultural value. The South West Creative Technology Network (SWCTN) is our case study. We build on Dovey et al.'s. work to visualise the cultural ecology supported and created by cohort-led R&D programmes. Our visualisations, combined with interview data, evidence that new connections create diverse forms of value, including inspiration, mentoring, training, and recruitment opportunities, and cooperation through collaborative working. We supplement social network and visualisation tools with rich qualitative data to explore the “why,” “how” and “to what end” of new connections, contributing to the field of Mixed Methods in Social Network Analysis (MMSNA). This methodology is novel to the field of creative economy research. We argue for new forms of R&D funding for the creative sector to take a cultural ecology approach if we wish to take seriously and invest in the diverse forms of value beyond economic drivers, sometimes described as “intangible,” that play an important role in building regional capacity, innovation and productivity.

Retinal prolactin isoform PRLΔE1 sustains rod disease in inherited retinal degenerations

PRLΔE1, a retina-specific isoform of prolactin, is expressed in multiple and diverse forms of canine inherited retinal degeneration (IRD). We find that while PRLΔE1 expression in rods is not associated with the initial phase of disease characterized by acute photoreceptor cell death, it is associated with the protracted phase of slow cell loss. Restoration of photoreceptors to a healthy state by gene-specific replacement therapy of individual IRDs successfully suppresses PRLΔE1 expression. Moreover, short-term PRLΔE1 silencing using shRNA results in preservation of outer nuclear layer thickness, suggesting PRLΔE1 drives retinal disease. However, longer-term observations reveal off-target toxic effects of the PRLΔE1 shRNA, precluding determination of its full therapeutic potential. Future research efforts aimed at enhancing the safety and specificity of PRLΔE1-targeting strategies may identify a potential universal intervention strategy for sustaining photoreceptors during the prolonged phase of multiple IRDs.

Urban Agriculture: Exploring Its Potential, Challenges, and Socio-Economic Impacts

Urban agriculture, the practice of growing and cultivating food within urban and peri-urban areas, has garnered increasing attention in recent years due to its potential to address various challenges related to food security, environmental sustainability, and socio-economic development. This review article provides a comprehensive exploration of urban agriculture, examining its multifaceted potential, the challenges it faces, and its socio-economic impacts in greater detail. The article delves into the diverse forms of urban agriculture, ranging from rooftop gardens and community allotments to vertical farming and aquaponics, highlighting their contributions to local food production, green spaces, and community cohesion. Additionally, the review discusses the challenges and constraints associated with urban agriculture in more depth, including issues related to land availability, soil contamination, water management, and regulatory hurdles. Furthermore, it examines the socio-economic impacts of urban agriculture with a nuanced perspective, exploring how it can lead to improved access to fresh produce, job creation, poverty alleviation, and social empowerment at both individual and community levels. By shedding light on the complexities of urban agriculture and providing a more comprehensive analysis of its potential and challenges, this review aims to inform policymakers, urban planners, researchers, and practitioners about the transformative potential of urban agriculture and the need for supportive policies and interventions to foster its sustainable growth and maximize its benefits for urban communities, the review dives deeper into the various forms of urban agriculture, providing detailed insights into their unique characteristics, benefits, and challenges. Rooftop gardens, for example, are explored not only for their contribution to local food production but also for their role in mitigating urban heat island effects, improving air quality, and enhancing building energy efficiency. Community allotments are examined in the context of social cohesion, community engagement, and opportunities for education and skill-building. Vertical farming and aquaponics are discussed in terms of their innovative technologies, resource efficiency, and potential scalability to meet the growing demand for fresh produce in urban areas, the review delves into the challenges and constraints associated with urban agriculture, offering nuanced analyses of their underlying causes and potential solutions. Land availability issues are examined in relation to urban sprawl, land-use planning policies, and competing demands for space in densely populated cities. Soil contamination concerns are explored in light of industrial legacies, brownfield redevelopment, and strategies for soil remediation and regeneration. Water management challenges are discussed in the context of water scarcity, pollution, and the need for sustainable irrigation practices in urban agriculture. Regulatory hurdles are analyzed in terms of their impact on the viability and scalability of urban agriculture initiatives, highlighting the importance of supportive policy frameworks, zoning regulations, and land-use planning strategies. the review provides a comprehensive examination of the socio-economic impacts of urban agriculture, drawing on empirical evidence from case studies and research findings. It explores how urban agriculture can contribute to improved food access and nutrition outcomes, particularly for vulnerable populations living in food deserts and low-income neighborhoods.

Fostering Dialogic Reading Through Older Siblings in Immigrant Latino Families: A Pilot Study

To promote children’s language development through designs that consider familial contexts, the authors explored the effectiveness of a dialogic reading intervention customized for older siblings in immigrant Latino families. The dialogic reading intervention, developed with components of training, modeling, and coaching, systematically supported older siblings’ dialogic reading use while reading with their younger siblings. Using the CROWD mnemonic, older siblings were taught to use a range of dialogic reading prompts, thereby nurturing diverse forms of engagement during shared interactive book reading (SIBR) sessions. Moreover, older siblings were taught the PEER mnemonic to enhance their ability to respond to their younger siblings’ input in manners conducive to promoting the latter’s language development. Effects of the intervention program on three older siblings’ (1) prompting and (2) responsiveness during SIBR were assessed using a multiple-baseline across participants design. Results indicate that two out of three older siblings increased prompt frequency and demonstrated improved responsiveness after receiving coaching and modeling support. Challenges faced by one older sibling are discussed, potentially attributed to individual language and literacy difficulties. Results tentatively indicate that older siblings have the capacity to acquire and apply dialogic reading skills if given appropriate instruction and support. These results illuminate opportunities to enhance SIBR techniques among siblings, underscoring the significant role older siblings in immigrant Latino families can play in providing enriched language input during SIBR.

The GFAP proteoform puzzle: How to advance GFAP as a fluid biomarker in neurological diseases.

Glial fibrillary acidic protein (GFAP) is a well-established biomarker of reactive astrogliosis in the central nervous system because of its elevated levels following brain injury and various neurological disorders. The advent of ultra-sensitive methods for measuring low-abundant proteins has significantly enhanced our understanding of GFAP levels in the serum or plasma of patients with diverse neurological diseases. Clinical studies have demonstrated that GFAP holds promise both as a diagnostic and prognostic biomarker, including but not limited to individuals with Alzheimer's disease. GFAP exhibits diverse forms and structures, herein referred to as its proteoform complexity, encompassing conformational dynamics, isoforms and post-translational modifications (PTMs). In this review, we explore how the proteoform complexity of GFAP influences its detection, which may affect the differential diagnostic performance of GFAP in different biological fluids and can provide valuable insights into underlying biological processes. Additionally, proteoforms are often disease-specific, and our review provides suggestions and highlights areas to focus on for the development of new assays for measuring GFAP, including isoforms, PTMs, discharge mechanisms, breakdown products, higher-order species and interacting partners. By addressing the knowledge gaps highlighted in this review, we aim to support the clinical translation and interpretation of GFAP in both CSF and blood and the development of reliable, reproducible and specific prognostic and diagnostic tests. To enhance disease pathology comprehension and optimise GFAP as a biomarker, a thorough understanding of detected proteoforms in biofluids is essential.

Investigating urban morphological drivers of household water use in developing economies: A structural equation model approach

Urban populations are snowballing, increasing household (HH) water consumption. The growing housing density, the expanding infrastructure, and altered land use patterns place increasing pressure on the water supply and usage. This makes it harder for urban HHs to obtain clean water and worsens water scarcity, with infrastructural and environmental implications for highly populated metropolitan areas. This study aims to quantitatively evaluate the impact of urban morphology on household water use in a developing economy using a Structural Equation Model (SEM), specifically within the growing urban centres surrounding Kolkata in South Bengal. The primary hypothesis projects an increase in urban morphological indicators and HH characteristics that significantly affect water use. The findings reveal that increases in urban morphological indicators are associated with a 34.2% decrease in HH water use, highlighting the importance of urban planning strategies that emphasize compact and diverse urban forms. This work highlights new ways of building cities that consider morphological aspects and allow cities to expand in a way that conserves HH water while being resilient to rapid urban change.

Development of Amphotericin B Decorated Gold Nanoparticles as a Promising Antileishmanial Nanoconjugate.

Leishmaniasis, attributed to the protozoan parasite Leishmania, manifests in diverse clinical forms, including cutaneous, mucocutaneous, and visceral leishmaniasis; VL constitutes a significant global health menace. Prevalent in tropical and subtropical regions, this affliction disproportionately impacts individuals below the poverty threshold, transmitted through the bite of female sandflies. Existing treatments, such as pentavalent antimony, miltefosine, and Amphotericin B, exhibit limitations. Despite the emergence of liposomal Amphotericin B (AmBisome) as a promising antileishmanial agent, its utility is impeded by adverse effects, elevated production expenses, and cytotoxicity. To address these challenges, our investigation introduces a potential remedy─a citrate-coated gold Amphotericin B nanoparticle formulation. Characterized using dynamic light scattering and transmission electron microscopy, this pioneering formulation exhibited efficacy against L. donovani Ag83 promastigotes as demonstrated by MTT cell viability testing. Evaluating internal reactive oxygen species (ROS) levels and dual staining with acridine orange and ethidium bromide unveiled its consequential impact on cell death. Significantly, our study discloses this novel nanoformulation's unprecedented inhibition of the trypanothione reductase enzyme. The findings posit the citrate-coated gold Amphotericin B nanoformulation as a promising and targeted antileishmanial agent, representing potential advancements in leishmaniasis therapeutics.

Analysis and discovery of procrastination patterns in a language learning MOOC

Online learning has been gaining a broad notoriety in society in the last years. The ease with which users from all over the world can learn is one of its main attractions. MOOCs are one of these technologies, which have enabled users to learn almost any subject of their interest. The use of MOOCs generates a massive amount of data that has been used by researchers with different goals: to predict dropout, predict grades and determine learning styles. Users of MOOCs face several challenges, some of which have been extensively studied. However, there are some of them, such as procrastination, whose study as a determining factor in the failure of such courses has not been addressed in sufficient depth. Through this paper, the influence of procrastination on the failure rates of users in a MOOC has been uncovered. Furthermore, by using process mining, this research has revealed the existence of a pattern of procrastination and the type of material used during study sessions by the users who fail the course. Speclifically, diverse forms of procrastination have been identified, resulting in differing effects on the educational outcomes attained by the user. These findings possess considerable implications, as they underscore the potential worth of detecting specific procrastination patterns to ascertain users who necessitate supplementary support during their educational pursuits within MOOCs.

Size and Morphology Dependent Activity of Cu Clusters for CO2 Activation and Reduction: A First Principles Investigation.

Various Cu-based materials in diverse forms have been investigated as efficient catalysts for electrochemical reduction of CO2; however, they suffer from issues such as higher over potential and poor selectivity. The activity and selectivity of CO2 electro reduction have been shown to change significantly when the surface morphology (steps, kinks, and edges) of these catalysts is altered. In light of this, size and morphology dependent activity of selected copper clusters, Cun (n=2-20) have been evaluated for the activation and reduction of CO2 molecule. The phase-space of these copper clusters is rich in conformations of distinct morphologies starting from planar, 2D geometries to prolate-shaped geometries and also high-symmetry structures. The binding efficiency and the activation of CO2 are highest for medium sized clusters (n=9-17) with prolate-morphologies as compared to small or larger sized CunCO2 clusters that are existing mainly as planar (triangular, tetragonal etc.) or highly-symmetric geometries (icosahedron, capped-icosahedron etc.), respectively. The best performing (prolate-shaped) CunCO2 conformations are quite fluxional and also they are thermally stable, as demonstrated by the molecular dynamics simulations. Furthermore, on these CunCO2 conformations, the step-by-step hydrogenation pathways of CO2 to produce value-added products like methanol, formic acid, and methane are exceptionally favorable and energy-efficient.

“Violence is Everywhere.” How Semi-Permeable Borders Facilitate Transnational Perpetration of Structural, Symbolic and Interpersonal Sexual and Gender-Based Violence

This article explores forced migrant women’s transnational experiences of Sexual and Gender-Based Violence (SGBV), emphasizing that dynamic forms of violence travel with women across international borders. Through qualitative interviews with Arabic-speaking forced migrant women who have experienced SGBV, we examine how the selective permeability of international borders facilitates the perpetration of SGBV. Our analysis identified SGBV was perpetrated against participants across a range of forced migration settings. Structural and symbolic violence also persisted across international borders, creating additional barriers to accessing formal support services. The findings indicate that international borders remain permeable to diverse forms of structural, symbolic and interpersonal SGBV.

A Nerve-Fibroblast Axis in Mammalian Lung Fibrosis.

Tissue fibrosis contributes to pathology in vital organs including the lung. Curative therapies are scant. Myofibroblasts, pivotal effector cells in tissue fibrosis, accumulate via incompletely understood interactions with their microenvironment. In an investigative platform grounded in experimental lung biology, we find that sympathetic innervation stimulates fibrotic remodeling via noradrenergic α1-adrenergic receptor engagement in myofibroblasts. We demonstrate the anti-fibrotic potential of targeted sympathetic denervation and pharmacological disruption of noradrenergic neurotransmitter functions mediated by α1-adrenoreceptors (α1-ARs). Using the α1-adrenoreceptor subtype D as a representative α1-AR, we discover direct noradrenergic input from sympathetic nerves to lung myofibroblasts utilizing established mouse models, genetic denervation, pharmacologic interventions, a newly invented transgenic mouse line, advanced tissue mimetics, and samples from patients with diverse forms of pulmonary fibrosis. The discovery of this previously unappreciated nerve-fibroblast axis in the lung demonstrates the crucial contribution of nerves to tissue repair and heralds a novel paradigm in fibrosis research.