An experimental study was undertaken to verify whether there is some correlation between the electron configuration of elements and their interaction in AAS. Thirty-four elements were studied pair by pair using 5 ratios interfering element/interfered element, R = 0,01, 0,1, 1, 10 and 100 in accordance with the columns and periods from the periodic table and by optimizing all instrumental parameters concerning the studied elements. It was observed that there are as many significant interferences (±5%) in the columns as in the periods, and that these interferences can be broken down into 4 categories according to the respective positions of interfering and interfered elements. From a theoretical point of view, this study brings up more questions than it answers. Therefore, it is difficult to explain the important interactions between Na, Mg, Al and Si (3rd period), which have similar and simple structures, by the difference in their peripheral layers alone. In the same way, Cr, Mn and Co (4th period), whose structures are very similar but more complex, behave very differently with regard to the same 14 interfering elements: Cr being strongly interfered by all of them, while Mn and Co remain remarkably stable. It should also be noted that the “ sinusoidal” action of certain interfering elements (positive or negative depending on R) is an enigma which cannot be solved by the formation of stable oxides in the flames (a case which would only be valid for inhibitions). If from a theoretical point of view the initial hypothesis cannot be confirmed, then from an analytical point of view, a great amount of accumulated data has supplied a great deal of information about the behaviour of one element in the presence of another.