In this study, the heat transfer and friction factor of a shell and helically coiled tube heat exchanger using Al2O3 / water nanofluid at 0.1%, 0.4% and 0.8% particle volume concentration were tested. The test was conducted under laminar flow condition at 5100 < Rei < 8700. It is found that the overall heat transfer coefficient, inner heat transfer coefficient and experimental inner Nusselt number are 24%, 25% and 28%, respectively, higher than water at 0.8% particle volume concentration of nanofluid. It is observed that the presence of nanoparticles further intensify the formation of secondary flow and proper mixing of fluid when nanofluid passes through the helically coiled tube. Apart from further flow intensification, higher thermal conductivity of nanofluid and random movement of nanoparticles contribute to the enhanced heat transfer coefficient. Also found that the friction factor increases over particle volume concentration and this is due to increased nanofluid viscosity while increasing particle volume concentration.