This presentation aims to provide an opportunity to learn about the history of xenophobia and racism against Latines in the United States, and to allow participants to gain a better understanding of how these experiences shape different aspects of Latine youth identity. Participants will also learn about cultural humility and competence as fundamental practices in working with Latines. We will present a brief overview on the history of xenophobia and racism against Latines in the United States, including a short video of the 2010 Medal of Freedom awardee, Sylvia Mendez, sharing her experience in the process of desegregating schools in California. Important constructs in the process of identity formation for Latine youth and the impact of discrimination and racism in this process will be explained. We will use selected clinical vignettes to illustrate this impact. To finalize, attendees will have the opportunity of engaging in an exercise to reflect on their own identity and understand the importance of cultural competence and humility when working with Latines. Discrimination and racism can be experienced by individuals that are identified as “Hispanic or Latino” in the United States. The history of xenophobia and racism against Latines in this country is best documented through the history of Mexican Americans in the Southwest. Thus, the historical review will primarily focus on this group, which continues to comprise the largest number of Latines in the country. Among Latines, it is important to understand the role of acculturation and acculturative stress in the process of identity formation, as experiences of discrimination and racism get internalized and impact youth mental health. Understanding this developmental process, as well as the historic and current experiences of marginalized groups, is critical to provide culture-centered and culture-affirming care. The practice of cultural humility and competence guides providers in this process and is essential in the therapeutic relationship with Latine youth. Xenophobia and racism have influenced Latine racial and ethnic identity formation since the 19th century, and the lingering political climate continues to reinforce this process. Child and adolescent psychiatrists have a critical role in uplifting marginalized youth and help heal intergenerational wounds.