Familial Forms Research Articles

“Unachievable adulthood?!” – exploring family formation journeys of care leavers in China

ABSTRACT This study examines the family formation journeys of care leavers in China, focusing on how they plan, navigate, and face challenges during this process. Using convenience and snowball sampling, 19 participants (16 care leavers, 3 care stayers) were interviewed. Thematic analysis identified three family pathways: (i) acquaintance-matched, (ii) self-matched, and (iii) marriage “on the way”. The findings reveal ongoing social exclusion and obstacles to family formation, particularly for male care leavers, due to financial pressures, discrimination, and trauma. The study highlights the need for targeted support and social change to improve outcomes for care leavers in China.

Relocate the base of the Arundian? A re-evaluation from south Cumbrian sections and implications for British and Irish Lower Carboniferous successions

The largely ice-free world of the ‘Chadian’–Arundian (early Visean) is investigated in two successions in south Cumbria to better understand the relationships between transgression, hiatus and the position of the basal Arundian. A detailed foraminiferal biostratigraphy is used to age-constrain the transition from the late ‘Chadian’ to early Arundian. This demonstrates a good synchronous relationship between the sequence stratigraphy of the two successions and the first occurrence of key species (mostly primitive archaediscids, rapidly followed by more evolved forms of the same family), suggesting that there is no significant hiatus and that the record of faunal changes is closely comparable in the key successions. A synthesis of other ‘Chadian’–Arundian boundary successions in Britain and Ireland indicates some key problems with the current Arundian boundary stratotype in practical usage. We propose a stratigraphically higher position for the Arundian boundary in the stratotype, which is more easily correlated to the Bobrikian and Moliniacian substages of eastern Europe and Belgium, respectively, and tied to the first occurrences of foraminifera species, allowing more robust age assessments, free from the confounding factors of inferred lithological or sequence stratigraphic changes.

Mammalian Diaphanous-related formin 1 (mDia1) inducing diabetic cardiomyopathy by regulating metabolic reprogramming

Abstract Background Mammalian Diaphanous-related formin 1 (mDia1) is one of the formin family proteins and acts as a rho-effector molecule which is involved in actin organization. Previous studies showed that mDia1 aggravated compensatory cardiac hypertrophy in response to pressure overload. However, the role of mDia1 in diabetic cardiomyopathy and its mechanisms remain elusive. Objective To clarify the mechanisms of mDia1 in DCM through mediating metabolic reprogramming. Methods 5-week-old of mDia1 ko mice were used to induce DCM by feeding high-fat diet (HFD) for 16 weeks. The blood glucose and body weight of the mice were measured regularly. Echocardiography was used to evaluate cardiac function. HE and WGA staining were used to evaluate hypertrophy of cardiomyocytes. Transmission electron microscopy and mitotracker staining were used to observe the morphology of mitochondrial in heart. Proteomics and metabolomics were used to explore the metabolites in hearts of mice. Primary neonatal cardiomyocytes were isolated and stimulated with 35 mM glucose and 250 μM palmitate in vitro. Adenovirus expressing shRNA of mDia1 was used to knockdown mDia1 in cardiomyocytes. Mitochondria were isolated from primary cardiomyocytes to verify the translocation of mDia1. Co-Immunoprecipitation was used to confirm the interaction between mDia1 with succinate dehydrogenase subunits A (SDHA). Results mDia1 had no effects to blood glucose and body weight after 16-week HFD feeding. Loss of mDia1 ameliorated diastolic dysfunction in DCM mice with shorter isovolumic relaxation time (IVRT) and increased E/A ratio in left ventricular. In addition, cardiac hypertrophy was significantly improved in mDia1 ko mice. mDia1 deficiency tended to maintain the normal mitochondrial structure. Results of proteomics showed that mDia1 was involved in mitochondrial function, ATP synthesis and metabolic pathways. Metabolomics showed that HFD induced accumulation of α-ketoglutaric acid in wild type mice compared with mDia1 ko mice. However, mDia1 ko significantly increased fumaric acid but did not affect succinyl-CoA and succinic acid compared with wild type mice. Furthermore，we found that mDia1 translocated into mitochondrial with high glucose and palmitate stimuli. Results of CoIP showed mDia1 interacted with SDHA both in cardiomyocytes and HEK293 cells. Conclusions mDia1 deteriorated DCM through translocating into mitochondrial and interacting with SDHA, a process dependent on metabolic pathways.Figure of Mechanism

A ADOÇÃO POR CASAIS HOMOAFETIVOS SOB A PERSPECTIVA DO DIREITO DE FAMÍLIA

Adoption by same-sex couples, from the perspective of Family Law, represents a significant advancement in equality of rights and recognition of diverse family forms. In many countries, Family Law has evolved to include same-sex couples in the adoption process, allowing them to form families and secure rights similar to those of heterosexual couples. Historically, same-sex couples have faced legal and social barriers to adopting children. However, case law and legislation have advanced, reflecting greater acceptance and understanding of same- sex relationships. For instance, Brazil’s Supreme Federal Court has ruled favorably on adoption by samesex couples, recognizing the validity of these unions and ensuring they can legally form a family. The decision to allow adoption by same-sex couples is based on the principle that the child's best interest should prevail. The ability to provide a loving and stable environment is considered more important than the adoptive parents' sexual orientation. Studies have shown that children adopted by same-sex couples develop as healthily as those adopted by heterosexual couples. Furthermore, legal recognition of adoption by same-sex couples contributes to the protection of children’s rights, ensuring they have access to all legal and social benefits provided by law.

Utility of polygenic risk score for prediction of dilated cardiomyopathy and modulation of severity of LV dysfunction among cases

Abstract Background Dilated cardiomyopathy (DCM) is a predominant cause of heart failure and a leading indication for cardiac transplantation. While rare genetic variants are established as causative factors in familial forms of the disease, recent genome-wide association studies (GWAS) have also underscored the significant contribution of common genetic variation to DCM. Polygenic scores (PGS) constructed from GWAS have demonstrated promise in risk stratification for a range of common diseases and may similarly have value for risk prediction in DCM. However, data regarding the clinical utility of PGS in DCM remains sparse. Purpose We aimed to evaluate the utility of PGS for prediction of DCM and its association with left ventricular ejection fraction (LVEF) and family history. We further aimed to assess the contribution of PGS in DCM patients with established causative rare variants (genotype-positive) and those without (genotype-negative). Methods We used a previously-constructed PGS, which was developed from a GWAS meta-analysis (8387 DCM cases and 939161 controls) and multi-trait analysis (MTAG) with cardiac MRI traits. In the present analysis, we calculated PGS for a newly assembled cohort of 978 DCM cases from a major university medical centre and 7207 controls from a national register. To evaluate the clinical utility of PGS, we built logistic regression models and assessed the association between PGS and DCM status. Subsequently, we performed subgroup analyses, including: i) individuals of European ancestry, ii) non-European ancestry, iii) males, iv) females, v) genotype-positive participants(n=193), and vi) genotype-negative participants (n=294). We then used linear and logistic regression models, respectively, to assess the associations of PGS with LVEF and documented family history of DCM. Results PGS demonstrated a significant enrichment among DCM cases compared to controls (OR per SD 1.93, P = 9.47E-68). This association persisted with consistent effect estimates - ranging from OR 1.5 to 2.2 - across all examined subgroups and demonstrated sufficient statistical significance (all P<1.58E-06) (Figure 1). Genotype-negative cases had a significantly higher PGS compared to genotype-positive individuals (P = 0.0015), although PGS was significantly enriched in both groups as compared to controls. Furthermore, among DCM cases, higher PGS was significantly associated with lower LVEF at first presentation (P=0.03, beta=-0.5% per SD) (Figure 2). There was no significant association found between PGS and family history. Conclusions PGS is strongly associated with risk of DCM, and may modulate the severity of LV dysfunction among DCM cases. Polygenic burden contributes to DCM risk in both genotype-positive and negative cases, although the contribution is stronger in patients without known causative rare variants. Overall, our results suggest a potential clinical applicability for PGS in DCM risk stratification.Figure 1.Association of PGS with DCMFigure 2.Association of PGS with LVEF

Molecular mechanisms underlying amyloid beta peptide mediated upregulation of vascular cell adhesion molecule-1 in Alzheimer's disease.

Amyloid beta (Aβ) deposition and neurofibrillary tangles are widely considered as the primary pathological hallmarks of familial and sporadic forms of Alzheimer's disease (AD). However, cerebrovascular inflammation, which is prevalent in 70% of AD patients is emerging as another core feature of AD pathology. In addition, activation of inflammatory signaling pathways have been observed in AD patients; specifically, cerebrovascular inflammation was found to be augmented in Alzheimer's patients. Our studies have demonstrated that the inflammation signaling pathway is upregulated in AD patient brains. Moreover, vascular cell adhesion molecule-1 (VCAM-1), a cerebrovascular inflammatory marker expressed on the blood-brain barrier (BBB) endothelium, was observed to be upregulated in APP,PS1 mice (a mouse model that overexpresses Ab42), as detected by dynamic SPEC/CT imaging. While there is a strong association between Aβ42 exposure and an increase in VCAM-1 expression, the mechanisms underlying the influence of Aβ42 on VCAM-1 expression remain understudied. Therefore, we investigated the hypothesis that Ab42 exposure increases VCAM-1 expression in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers. In addition, reverse phase protein array assays (RPPA) and immunocytochemistry demonstrated that Ab42 increases VCAM-1 expression through the Src/p38/MEK signaling pathway specifically within the blood-brain barrier (BBB) endothelium. In summary, these results demonstrate that Ab42 augments cerebrovascular inflammation by elevating VCAM-1 expression via Src/MEK/p38 pathway. Hence, targeting VCAM-1 at the BBB as a diagnostic and therapeutic marker may hold potential for detecting and mitigating cerebrovascular inflammation in Alzheimer's disease. Significance Statement While considered a core pathological feature of Alzheimer's disease, molecular pathways leading to cerebrovascular inflammation remain partially understood. Moreover, clinical diagnostic methods for detecting cerebrovascular inflammation are underdeveloped. In this study, we demonstrated VCAM-1 detection using radio-iodinated VCAM-1 antibody and SPECT/CT imaging. The study demonstrated that the exposure to Aβ42 increases VCAM-1 expression on the BBB endothelium via Src/p38/MEK pathway. These findings are expected to aid in the development of diagnostic and therapeutic approaches for addressing cerebrovascular inflammation in AD.

Forms of the Mother Right: Marxism's Matriarchal Origins from Friedrich Engels to Lu Märten

AbstractThe nineteenth‐century discovery of the matrilineal origins of society shattered assumptions about the necessity of the bourgeois family. For Marxists, ethnographic studies of the mother right provided an aesthetic form to reevaluate the “woman question” from a scientific perspective. Although Marx and Engels had long rejected the idea of the family in favor of “family forms,” Engels's adaptation of Morgan's Ancient Society (1877) in Der Ursprung der Familie, des Privateigentums und des Staats (1884) was canonized as the authoritative Marxist text on the subject. While the ethnographic form enabled the denaturalization of the family, its racialized and gendered temporality undercut socialist critiques of social forms. This article introduces Lu Märten's queer utopian response to the mother right, Geschichte der Frau vom Mutterrecht bis zur Gegenwart (1947), which dispenses with the evolutionary structure of the ethnographic study to offer a vision of polyamorous and androgynous forms in a classless society.

Genetic diversity and structure of Persicaria amphibia (Polygonaceae) in South Korea using genotyping by sequencing.

Persicaria amphibia, a member of the Polygonaceae family, exists both aquatic and terrestrial forms. It is native to North America, Asia, Europe, and some parts of Africa. This study aimed to determine the genetic diversity within and among populations of P. amphibia and the distribution characteristics of each population to investigate insights into the genetic structure and conservation of P. amphibia. In this study, the genetic diversity and structure of 84 P. amphibia individuals from 7 populations in South Korea were analyzed using genotyping-by-sequencing (GBS). We used 2,469 single nucleotide polymorphisms (SNPs) to analyze genetic diversity, principal components, structure, and phylogeny. Our results showed a mean observed heterozygosity and mean expected heterozygosity of 0.34409 and 0.34082, respectively. Genetic diversity analysis indicated that the variation among populations (60.08%) was greater than that within populations (39.92%). Fixation index values, principal components analysis, structure, and phylogeny analyses showed that the population in Gyodongdo, Ganghwa Island was highly different. These results provide important insights for better understand the population history and genetic structure of P. amphibia.

The Genetics of Chiari 1 Malformation.

Chiari malformation type 1 (CM1) is a structural defect that involves the herniation of the cerebellar tonsils through the foramen magnum, causing mild to severe neurological symptoms. Little is known about the molecular and developmental mechanisms leading to its pathogenesis, prompting current efforts to elucidate genetic drivers. Inherited genetic disorders are reported in 2-3% of CM1 patients; however, CM1, including familial forms, is predominantly non-syndromic. Recent work has focused on identifying CM1-asscoiated variants through the study of both familial cases and de novo mutations using exome sequencing. This article aims to review the current understanding of the genetics of CM1. We discuss three broad classes of CM1 based on anatomy and link them with genetic lesions, including posterior fossa-linked, macrocephaly-linked, and connective tissue disorder-linked CM1. Although the genetics of CM1 are only beginning to be understood, we anticipate that additional studies with diverse patient populations, tissue types, and profiling technologies will reveal new insights in the coming years.

Distribution and determinants of early marriage and motherhood: a multilevel and geospatial analysis of 707 districts in India

BackgroundEarly marriage and motherhood have long been prevalent in India, with 44.5% of women aged 20–24 reporting marriage before 18 in NFHS 3 (2005–2006), dropping to 26.8% in NFHS 4 (2015–2016). Early motherhood has also seen a significant decline, with first births by age 18 decreasing from 34.3% in NFHS I to 8.2% in NFHS V. Despite these improvements, significant regional disparities persist due to social, normative, and legal factors. This study investigates the spatial heterogeneity of early marriage and motherhood across Indian districts, offering a multilevel analysis that reveals critical local variations often obscured at broader levels. Understanding these patterns is crucial for targeted policy interventions and addressing the root causes of early marriage and motherhood.MethodsUtilizing data from the fifth round of National Family Health Survey, this study employs multilevel logistic regression and geospatial analysis to assess the determinants and spatial distribution of early marriage and early motherhood among ever-married women in India. The analysis incorporates individual, household, and community-level variables, complemented by spatial analysis techniques, including Empirical Bayes Bivariate Moran’s I values and LISA cluster maps, to identify regional patterns and hotspots.ResultsThis study revealed that educational attainment emerged as a critical determinant, with uneducated women significantly more likely to marry early. Socioeconomic factors, such as poverty and limited mass media exposure, also heightened the risk of early marriage and motherhood. Caste and religion were significantly associated with these events, with marginalized groups facing higher prevalence. Spatial analysis revealed significant geographic disparities, with central and eastern regions showing higher concentrations of early marriage and motherhood. District-level characteristics and the influence of neighboring districts were also significant, highlighting the importance of localized interventions.ConclusionsThe findings underscore the critical role of education, economic empowerment, and media literacy in mitigating early marriage and motherhood risks. The study calls for multi-sectoral interventions in geographical hotspots to break the cycle of early family formation and promote reproductive health. Policies enhancing educational opportunities, addressing economic disadvantages, and considering district-specific factors are essential. Comprehensive strategies are necessary to empower women, foster reproductive health, and address the multifaceted nature of early marriage and motherhood in India.

Reproductive behavior of youth: theory and key factors

The reproductive behavior concept has been considered, which is the key to personal behavior formation in the context of childbirth and family formation. The analysis of approaches to reproductive behavior has been carried out, due to which main factors influencing reproductive behavior patterns formation have been highlighted. Material provision, the possibility to give children quality education and decent living conditions, the place of family and children in the system of values, as well as cultural norms in the complex influence behavior development in relation to family planning and childbirth. Currently, there is a problem of combining parenthood and the image of a successful careerist, so there is competition between the value aspects. The value of family and parenthood remains high, while the need for children decreases. In addition, psychological motives for having children prevail over economic and social ones. The topic of reproductive letting down contains many sides that need to be subjected to analysis. The difficulty lies in the fact that not only we operate with actual objective data, but also deal with personal and psychological characteristics, which complicates the analysis procedure, so it is necessary to further study the issue.

Pink1/Parkin deficiency alters circulating lymphocyte populations and increases platelet-T cell aggregates in rats

Parkinson’s disease (PD) is the most common progressive neurodegenerative movement disorder and results from the selective loss of dopaminergic neurons in the substantia nigra pars compacta. Pink1 and Parkin are proteins that function together in mitochondrial quality control, and when they carry loss-of-function mutations lead to familial forms of PD. While much research has focused on central nervous system alterations in PD, peripheral contributions to PD pathogenesis are increasingly appreciated. We report Pink1/Parkin regulate glycolytic and mitochondrial oxidative metabolism in peripheral blood mononuclear cells (PBMCs) from rats. Pink1/Parkin deficiency induces changes in the circulating lymphocyte populations, namely increased CD4 + T cells and decreased CD8 + T cells and B cells. Loss of Pink1/Parkin leads to elevated platelet counts in the blood and increased platelet-T cell aggregation. Platelet-lymphocyte aggregates are associated with increased thrombosis risk suggesting targeting the Pink1/Parkin pathway in the periphery might have therapeutic potential.

Whose Egg, Whose Sperm, Whose Household Registration? Reproductive Decisionmaking Among LGBT Parents in China

This article examines how LGBT individuals and couples in China make reproductive decisions in a sociopolitical context characterized by homophobia and an absence of LGBT familial rights and legal recognition. The existing literature on LGBTQ+ childbearing and family formation, based primarily in Euro-American countries, tends to focus on the central role of same-sex marriage legalization and features marriage as the core intimate bond that bestows parental and other familial rights. This article argues that China’s household registration (hukou) system is an equally, if not more, salient regulatory system that determines daily life opportunities, access to state-subsidized schooling and health care, life-long social welfare, and placement in a hierarchy of urban versus rural citizenship. LGBT intending parents in China make reproductive decisions with a child’s hukou in mind, treating genetic contributions, gestational labor, and legal parental status as flexible resources to achieve desired hukou outcomes. The hukou system encourages reproductive strategies that make and unmake LGBT kinship, securing family bonds that otherwise lack legal and social recognition while potentially risking parental precarity. The article suggests new directions for LGBT rights advocacy by focusing on the governing systems and statuses that determine access to key citizenship resources and family rights.

Execution of revised BMIM similarity coefficient for part family formation in reconfigurable manufacturing system

The reconfigurable manufacturing system (RMS) is an advanced manufacturing strategy that enables precise adjustment of functionality and capacity to meet fluctuating demands economically. RMS focuses on part families, allowing configurations to be adapted for new part requirements. Optimizing flow line design to produce various parts involves minimizing reconfigurations and associated costs by enhancing operation sequence similarity. This article proposes a novel sequence optimization using the Longest Common Subsequence (LCS) method to reduce bypassing moves and machine idle times. The study introduces a similarity coefficient derived from LCS and employs average linkage hierarchical clustering to categorize parts in a case study. Unlike traditional methods, this approach considers material movements both before the initial machine and after the final processing station, addressing gaps in bypassing move calculations. The impact of different weighting scenarios for Type-II moves (ω) and machine idleness (β) on clustering was examined. For example, with Type-II move weights (ω) of {1.0, 0.6, 0.3, 0.0} and equal weightings for bypassing moves (α) and machine idleness (β) set at 0.5, a threshold value of 0.3 results in eight clusters, such as Cluster 1 {1, 11, 10, 12} and Cluster 3 {3, 5, 6, 4, 15, 9, 13, 14, 7, 8}. Lower threshold values lead to fewer clusters with larger sizes, indicating a more consolidated part family grouping. Various Type-II move weights and material handling scenarios demonstrate how different weighting configurations affect clustering and part family sizes. This approach enhances RMS efficiency by integrating comprehensive material handling considerations and optimizing clustering based on operational similarities.

TRADITIONAL FAMILY VALUES OF THE RUSSIAN WORLD: ANCIENT RUSSIAN LITERATURE AND MODERNITY

This article examines the transformation of traditional patriarchal ideas about family life in modern Russian society. The author notes the continuity of traditions, due to the demands of the modern social sphere, and popularisation of heroes whose images are imprinted in the monuments of ancient Russian literature. In modern Russian society, there is an increasing interest in the traditional family model, and there is a need to create positive examples that can serve as a support for the formation of a healthy family. The article analyses the images of married couples in the monuments of ancient Russian literature in terms of the relevance of their use in the modern world in order to form a positive assessment of traditional family values among young people.

Papillary microcarcinoma in three generations of the first degree relatives

Family papillary microcarcinoma of the thyroid gland is observed in 3–10 % of patients with cancer from follicular epithelial cells. Diagnosis and treatment are controversial. Three patients from the same family of the first degree of kinship were operated for family papillary microcarcinoma of the thyroid gland in Voronezh Regional Clinical Hospital No. 1. Only the first patient complained of the neck deformity, her son and granddaughter had an asymptomatic course of the disease. Metastases to the lymph nodes of the neck and bilateral localization of the tumor were not revealed. In the third generation, multifocal tumor growth was diagnosed at the age of 19. All patients underwent thyroidectomy. In the first patient, the period of relapse–free follow-up after surgery was 18 years, in the second and third – 5 years. In the family form of papillary thyroid carcinoma, we consider active screening of relatives justified since the disease in the new generation may develop at a younger age and with the risk of multifocal thyroid damage even in microcarcinomas.

Familial bisalbuminemia

Bisalbuminemia is characterized by two albumin peaks in the electrophoresis of serum. There are different forms of bisalbuminemia: inherited and acquired. The acquired form is mainly transitory, whereas the familial form is permanent. The frequency of bisalbuminemia in the general population has been reported to be between 0.0003 and 0.01%. This paper presents acase of familial bisalbuminemia as well as the family tree-to the extent obtainable. Amarried couple, in which the husband had bisalbuminemia, had seven children and 18grandchildren. Bisalbuminemia was also found in two children and in two grandchildren.

Family Formation and Crime

We perform a large-scale analysis of the impact of family formation on crime. For mothers, criminal arrests drop precipitously in the first few months of pregnancy, decreasing 50 percent overall. Men show a sustained 20 percent decline in crime that begins around pregnancy, although arrests for domestic violence spike at birth. A separate design using parents of stillborn children to estimate counterfactual arrest rates reinforces the main findings. Marriage, in contrast, is not associated with any sudden changes and marks the completion of a gradual 50 percent decline in arrests for both men and women. (JEL J12, J16, J22, K42)

Diverse Concepts in Definitions of Dilated Cardiomyopathy: Theory and Practice.

Our understanding of dilated cardiomyopathy (DCM) is evolving as new insights into the underlying pathophysiology become available. Professional organizations and clinical experts are improving definitions of DCM, allowing for more accurate treatment recommendations. This review summarized key published literature describing definitions and/or diagnostic criteria for DCM. Embase was searched from database inception to September 19, 2022 for 1) publications reporting definitions of DCM by major professional organizations and related opinion papers, and 2) clinical studies in DCM and heart failure with reduced ejection fraction. Sixty-eight records were included in this review. Definitions of DCM provided by two major professional organizations (American Heart Association (AHA) and European Society of Cardiology (ESC)) agreed on the clinical presentation of DCM; however, they differed in the classification of DCM within the larger context of cardiomyopathy taxonomies. Both organizations agreed that DCM could be clinically defined by the presence of left ventricular dilation and contractile dysfunction in the absence of abnormal loading conditions and severe coronary artery disease. AHA guidelines divided cardiomyopathies into two major groups (primary and secondary) based on predominant organ involvement. DCM was classified as primary cardiomyopathy with mixed (genetic and/or acquired) etiology. Conversely, ESC published a clinically oriented taxonomy in which cardiomyopathies were grouped into specific morphological and functional phenotypes; each was subclassified into familial or non-familial forms. Opinion papers further elaborated on the complex interplay between genetics and environment in the etiology of DCM. Several articles summarized the importance of the new and updated diagnostic tools, such as cardiac magnetic resonance imaging, electrocardiogram, and other biomarkers, in correctly identifying the etiology of DCM. Within clinical studies, most inclusion criteria used standard definitions proposed by leading professional associations (AHA and ESC). Clinical study investigators sometimes used a narrower definition of DCM using additional criteria for the left ventricular ejection fraction threshold value and left ventricular dilatation. Current efforts in cardiology research are focused on a more granular understanding of DCM etiology and the natural history of the disease. Definitions of DCM found in clinical studies mainly rely on published guidelines, with some studies adding idiosyncratic inclusion criteria refining the broad definitions of DCM.

Ovariectomy and High Fat-Sugar-Salt Diet Induced Alzheimer's Disease/Vascular Dementia Features in Mice.

While the vast majority of Alzheimer's disease (AD) is non-familial, the animal models of AD that are commonly used for studying disease pathogenesis and development of therapy are mostly of a familial form. We aimed to generate a model reminiscent of the etiologies related to the common late-onset Alzheimer's disease (LOAD) sporadic disease that will recapitulate AD/dementia features. Naïve female mice underwent ovariectomy (OVX) to accelerate aging/menopause and were fed a high fat-sugar-salt diet to expose them to factors associated with increased risk of development of dementia/AD. The OVX mice fed a high fat-sugar-salt diet responded by dysregulation of glucose/insulin, lipid, and liver function homeostasis and increased body weight with slightly increased blood pressure. These mice developed AD-brain pathology (amyloid and tangle pathologies), gliosis (increased burden of astrocytes and activated microglia), impaied blood vessel density and neoangiogenesis, with cognitive impairment. Thus, OVX mice fed on a high fat-sugar-salt diet imitate a non-familial sporadic/environmental form of AD/dementia with vascular damage. This model is reminiscent of the etiologies related to the LOAD sporadic disease that represents a high portion of AD patients, with an added value of presenting concomitantly AD and vascular pathology, which is a common condition in dementia. Our model can, thereby, provide a valuable tool for studying disease pathogenesis and for the development of therapeutic approaches.