Intelligent mixed-flow disassembly serves an important role in enhancing the flexible operation capability of the disassembly line for multi-variety and small-batch used electromechanical products, and in forming the scale benefit of recycling. However, in mixed-flow disassembly lines, pre-planning the disassembly sequence for products is typically unfeasible and can lead to “over-disassembly” or “under-disassembly”, resulting in economic losses. This is attributed to significant variations in disassembly features, such as internal structural damage and subassembly recycling income, even within the same type of used electromechanical product. These differences contribute to considerable uncertainties in disassembly sequence planning. To this end, a method is proposed to leverage dynamic disassembly feature information for mining disassembly rules, efficiently driving disassembly sequences real-time planning, and realizing intelligent optimization of product disassembly profit on mixed-flow disassembly line. First, a multi-matrix collaboration based dynamic representing method of product disassembly feature information is proposed. It aims to eliminates the influence of uncertain information on the disassembly sequence planning by recording real-time disassembly feature information, such as disassembly operation time and subassembly recycling income. On this basis, a rule-driven disassembly sequences real-time planning model is built. This model realizes disassembly sequence real-time planning based on offline mined rules using the updated disassembly feature information in matrices. Finally, an improved gene expression programming-based disassembly rule offline mining algorithm is proposed, which incorporates a mutation probability mapping function to improve the efficiency and effectiveness of disassembly rule mining. A case study containing two products with differences in structure and function are used to confirm the effectiveness of the proposed method.