Liquid Form Research Articles

Cyclophosphamide: Lyo to Liquid – A Comprehensive Review

Cyclophosphamide has been a key chemotherapeutic and immunosuppressive agent for decades. Its development, from lyophilized powder to sterile liquid formulations, represents significant progress in improving drug stability, ease of administration, and patient safety. Initially approved as a lyophilized powder in 1959, Cyclophosphamide provided extended shelf life but required reconstitution before use, posing challenges such as contamination risk and preparation errors. Advances in formulation led to the development of sterile liquid forms, which eliminate the need for reconstitution, offering more convenience and minimizing handling risks. These liquid formulations incorporate stabilizing agents to maintain drug integrity and ensure bioequivalence with the lyophilized form. The review highlights key regulatory milestones, including the first liquid formulation approvals in 2018 and 2020, and discusses the patents that contributed to these innovations. Furthermore, it explores future perspectives, such as improving bioavailability, enhancing patient compliance, and incorporating uroprotective agents directly into the formulation. These advancements are critical for maintaining Cyclophosphamide’s role in oncology and ensuring it remains an effective treatment option for cancer patients. Key Words: Cyclophosphamide, Lyophilized formulation, Sterile liquid formulation, Chemotherapy, Drug stability, Drug delivery systems

Liquid vortex surface deformation probed by light reflection

Abstract We propose a method that combines an optical system with image processing techniques to scrutinize the dependence of liquid vortex deformation on varying angular velocity based on light reflection on liquid surfaces due to dynamic wettability. In our experiment, a broadened and collimated laser beam is directed onto curved surfaces, providing information on the vortex parameters through the analysis of the reflected beam profile. Additionally, the physical model of the liquid surface in a rotating cylinder before dewetting is examined. We investigate the liquid vortex forms of a saline solution and propylene glycol across various angular velocities, comparing them to the ideal parabolic vortex surface shape. The results show that, under the same experimental conditions, the vortex profiles of both solutions are equivalent. The vortex surface shape at certain angular velocity values, as determined by fitting plots, closely resembles a parabola, with R2 > 99%. The proposed method introduces a new approach for characterizing the dynamics of liquids as well as monitoring natural phenomena.

Comparative Study of Polymer of Intrinsic Microporosity-Derivative Polymers in Pervaporation and Water Vapor Permeance Applications

This study assesses the gas and water vapor permeance of PIM-derivative thin-film composite (TFC) membranes using pervaporation and “pressure increase” methods, and provides a comparative view of “time lag” measurements of thick films obtained from our previous work. In this study, TFC membranes were prepared using PIM-1 and homopolymers that were modified with different side groups to explore their effects on gas and water vapor transport. Rigid and bulky aliphatic groups were used to increase the polymer’s free volume and were evaluated for their impact on both gas and water transport. Aromatic side groups were specifically employed to assess water affinity. The permeance of CO2, H2, CH4 and water vapor through these membranes was analyzed using the ‘pressure increase’ method to determine the modifications’ influence on transport efficiency and interaction with water molecules. Over a 20 h period, the aging and the permeance of the TFC membranes were analyzed using this method. In parallel, pervaporation experiments were conducted on samples taken independently from the same membrane roll to assess water flux, with particular attention paid to the liquid form on the feed side. The significantly higher water vapor transport rates observed in pervaporation experiments compared to those using the “pressure increase” method underline the efficiency of pervaporation. This efficiency suggests that membranes designed for pervaporation can serve as effective alternatives to conventional porous membranes used in distillation applications. Additionally, incorporating “time lag” results from a pioneering study into the comparison revealed that the trends observed in “time lag” and pervaporation results exhibited similar trends, whereas “pressure increase” data showed a different development. This discrepancy is attributed to the state of the polymer, which varies significantly depending on the operating conditions.

Annotating full-scan MS data using tandem MS libraries.

Full-scan mass spectrometry (MS) data from both liquid chromatography (LC) and MS imaging capture multiple ion forms, including their in-source fragments. Here we leverage such fragments to structurally annotate full-scan data from LC-MS or MS imaging by matching against peak intensity scaled tandem MS spectral libraries using precursor-tolerant reverse match scoring. Applied to inflammatory bowel disease and imaging datasets, we show the approach facilitates re-analyses of data in public repositories.

Therapeutic potential of phytocompounds of Bacopa monnieri (L.) Wettst (literature review)

The aim of the work was to evaluate the pharmacological effects and therapeutic potential of individual compounds and extracts of B. monnieri based on the analysis of data from scientific periodicals regarding chemical composition and biological action. Theoretically significant were the studies of the materials of the scientific-metric database PubMed and Google Scholar over the last five years regarding the chemical composition and biological action of extracts based on B. monnieri and their individual components. The search query was carried out by the Latin name of the plant, with the exception of publications related to botanical research. In separate PubChem searches, names of individual phytocompounds were used to establish structure and distribution in plants. The SuperPred web server was used to predict therapeutic potential. The authors analyzed the chemical composition of the extracts, presented the structural and pharmacological characteristics of bacosides and their aglycones: bacosin and juubogenin, cucurbitacin E, loliolide, betulinic and asiatic acids and the flavonoid oroxindin. The mechanism of action of bacoside on β-amyloid is characterized and illustrated. Using machine learning, the prospects for using the main compounds of bacopa to create drugs were calculated taking into account the ATC classification, their biological effects and alternative plant sources were given. Experimental animal studies of whole aqueous or ethanolic extracts of B. monnieri have been found to support a cognitive enhancement effect. The extract was not toxic to humans. Numerous clinical trials show the effectiveness of the use of extracts in the treatment of anhedonia, depression, Alzheimer's disease, Parkinson's disease, dementia and hyperactivity. An analysis of clinical studies in Ukraine shows that drugs based on B. monnieri can be used in the complex treatment of cognitive impairment associated with dyscirculatory encephalopathy in adults and perinatal CNS damage in children. Considering the amphiphilicity of bacosides and the non-toxicity of extracts, they can be involved in the development of various dosage forms with a wide range of therapeutic applications. Further study of the pharmacological action of B. monnieri and the development of drug technology for solid and liquid dosage forms based on it are promising.

Moisture‐Driven Actuators

AbstractWater constitutes a huge circulation network in solid, liquid and gaseous forms that contains inestimable recyclable energy. Obtaining energy from gaseous moisture is challenging but of great significance to promote the energy upgrading. The emergence of moisture‐driven actuator (MDA) provides an effective way in converting moisture energy to mechanical energy. The MDA can combine with water molecules through hygroscopicity and swell to produce macroscopic deformation. Due to the wide distribution of humidity and the wireless driving mode, MDA shows great application potential in the fields of environmental monitoring, remote control and energy harvesting. This paper comprehensively reviews the research progress of MDA from aspects of hydrophilic materials, structures, preparing methods, multi‐response integration and applications, aiming at providing guidance for the design, preparation and application of MDA. Besides, the challenges faced by MDA are analyzed and corresponding solutions are proposed, which points out the next stage developing direction of MDA.

Sublethal Damage Caused by Cold Plasma on Bacillus cereus Cells: Impact on Cell Viability and Biofilm-Forming Capacity.

The Bacillus cereus group represents a serious risk in powdered and amylaceous foodstuffs. Cold plasma (the fourth state of matter) is emerging as an alternative effective nonthermal technology for pasteurizing a wide range of matrices in solid, liquid, and powder form. The present study aims to evaluate the mechanisms involved in Bacillus cereus inactivation via cold plasma, focusing on (i) the technology's ability to generate damage in cells (at the morphological and molecular levels) and (ii) studying the effectiveness of cold plasma in biofilm mitigation through the direct effect and inhibition of the biofilm-forming capacity of sublethally damaged cells post-treatment. Dielectric barrier discharge cold plasma (DBD-CP) technology was used to inactivate B. cereus, B. thuringiensis, and B. mycoides under plasma power settings of 100, 200, and 300 W and treatment times ranging from 1 to 10 min. Inactivation levels were achieved in 2-7 log10 cycles under the studied conditions. Percentages of sublethally damaged cells were observed in a range of 45-98%, specifically at treatment times below 7 min. The sublethally damaged cells showed poration, erosion, and loss of integrity at the superficial level. At the molecular level, proteins and DNA leakage were also observed for B. cereus but were minimal for B. mycoides. Biofilms formed by B. cereus were progressively disintegrated under the DBD-CP treatment. The greater the CP treatment intensity, the greater the tearing of the bacteria's biofilm network. Additionally, cells sublethally damaged by DBD-CP were evaluated in terms of their biofilm-forming capacity. Significant losses in the damaged cells' biofilm network density and aggregation capacity were observed when B. cereus was recovered after inactivation at 300 W for 7.5 min, compared with the untreated cells. These results provide new insights into the future of tailored DBD-CP design conditions for both the inactivation and biofilm reduction capacity of B. cereus sensu lato species, demonstrating the effectiveness of cold plasma and the risks associated with sublethal damage generation.

A Self-Healing, Flowable, Yet Solid Electrolyte Suppresses Li-Metal Morphological Instabilities.

Lithium metal (Li0) solid-state batteries encounter implementation challenges due to dendrite formation, side reactions, and movement of the electrode-electrolyte interface in cycling. Notably, voids and cracks formed during battery fabrication/operation are hot spots for failure. Here, a self-healing, flowable yet solid electrolyte composed of mobile ceramic crystals embedded in a reconfigurable polymer network is reported. This electrolyte can auto-repair voids and cracks through a two-step self-healing process that occurs at a fast rate of 5.6µm h-1. A dynamical phase diagram is generated, showing the material can switch between liquid and solid forms in response to external strain rates. The flowability of the electrolyte allows it to accommodate the electrode volume change during Li0 stripping. Simultaneously, the electrolyte maintains a solid form with high tensile strength (0.28MPa), facilitating the regulation of mossy Li0 deposition. The chemistries and kinetics are studied by operando synchrotron X-ray and in situ transmission electron microscopy (TEM). Solid-state NMR reveals a dual-phase ion conduction pathway and rapid Li+ diffusion through the stable polymer-ceramic interphase. This designed electrolyte exhibits extended cycling life in Li0-Li0 cells, reaching 12000 h at 0.2mA cm-2 and 5000 h at 0.5mA cm-2. Furthermore, owing to its high critical current density of 9mA cm-2, the Li0-LiNi0.8Mn0.1Co0.1O2 (NMC811) full cell demonstrates stable cycling at 5mA cm-2 for 1100 cycles, retaining 88% of its capacity, even under near-zero stack pressure conditions.

Effects of freebase/protonated nicotine concentration, liquid composition and electrical power on throat hit in direct-to-lung vaping: theory and clinical measurements

BackgroundFor decades, the tobacco industry has engineered the sensory characteristics of combustible tobacco products including the degree of harshness experienced at the back of the throat. Commonly referred to as...

Utilization of Local Wisdom of Antanan (Centella Asiatica) and Badotan (Ageratum Conyzoides L.) Plants for Anti-bacterial Edible Film of Pumpkin Seeds

Edible film is a thin layer made from consumable materials, formed on top of or placed between food components, functioning as a barrier to mass transfer such as moisture, oxygen, and solutes. It is made from edible biopolymers and food-grade additives. The development of edible film packaging in this study was carried out by utilizing pumpkin skin and seeds that have not been adequately used and by exploring the addition of natural antimicrobial compounds, namely antanan and badotan, to enhance the inhibitory effect of edible films made from pumpkin seeds that meet food standards.In this study, the extraction of yellow pumpkin seeds, antanan, and badotan was performed, followed by organoleptic and phytochemical tests. An edible film formulation was made from yellow pumpkin seeds, varied with antanan and badotan, and tested for moisture content, solubility, pH, and antibacterial properties. The characteristic test results showed that the badotan leaf simplicia was dark green, with a bitter taste and an astringent aromatic odor typical of badotan. The extract was blackish-green in color, with an aromatic odor typical of badotan, and a very bitter taste. Antanan leaf simplicia had a typical aromatic odor, an astringent taste, and was solid green in color. The antanan leaf extract had a typical antanan odor, a very bitter taste, and was thick green in color. Pumpkin seed simplicia had a typical pumpkin smell, an astringent taste, and was thick green in color. The pumpkin seed extract had a smell of ethanol solvent, a bitter taste, and was brownish-green and in the form of a thick liquid. The potential bioactive compounds in badotan leaves included alkaloids, steroids, phenolics, and saponins. Antanan leaves and pumpkin seeds contained flavonoids, alkaloids, steroids, phenolics, and saponins. The results showed that the edible film formulation of pumpkin seeds combined with badotan and antanan (1:2) appeared tighter and smoother and did not break. The formulation of pumpkin seeds and badotan (1:2) had a moisture content of 0.0380%, a solubility content of 0.2075%, and a pH of 5.8. The pumpkin seed and antanan (1:2) formulation had a moisture content of 0.0732%, a solubility content of 5.7269%, and a pH of 5.8. The edible film antibacterial activity test against Staphylococcus aureus used the disc diffusion method and obtained an inhibition zone of 1.8 mm for pumpkin seed edible film, 12.4 mm for pumpkin seed (1:2) edible film, and 17.6 mm for pumpkin seed (1:2) edible film.

A Study on the Efficacy of Four Chemical Decontaminants against High-concentration Surrogates of Bacteria, Toxin, and Virus Biological Agents

If a nation or a terrorist organization produced biological agents, they are likely stored in a form of liquid concentrate. In the present study, four chemical reagents, hydrogen peroxide, sodium dichloroisocyanurate (NaDCC), Perasafe, and DF200, were investigated on their potentials as safe, efficient and eco-friendly decontaminants for biological agents. <i>Escherichia coli</i>, α-amylase, and bacteriophage T4 were used as surrogate strains for biological agents. Hydrogen peroxide and DF200 showed drawbacks of a rapid heat evolution upon neutralization and thick foam building up, respectively. Perasafe was effective against <i>E. coli</i> and T4, but it did not inactivate α-amylase while the others were able to inactivate all three types of the surrogates. NaDCC was the most suitable decontaminant for its effectiveness against all three types of surrogates at low concentrations and being able to be neutralized without aforementioned problems.

Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase produced with Trichoderma reesei CBS 114044 (ECONASE® XT) for pigs for fattening, laying hens and minor poultry species (AB Enzymes Finland Oy)

Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a product containing endo‐1,4‐β‐xylanase (ECONASE® XT) as a zootechnical feed additive (digestibility enhancer) for pigs for fattening, laying hens and minor poultry species. ECONASE® XT is available in two liquid and three solid forms and is produced with a genetically modified strain of Trichoderma reesei (CBS 114044). The FEEDAP Panel concluded that the genetic modification of the production strain does not raise any safety concerns, and viable cells of the production strain and its DNA were not detected in the final products. The Panel also concluded that ECONASE® XT is safe for pigs for fattening, laying hens and minor poultry species at the proposed conditions of use. The use of the additive raises no safety concerns for the consumers of products derived from animals fed with the additive or for the environment. The liquid and solid forms of ECONASE® XT are non‐irritant to the skin, but only the liquid forms were confirmed as non‐irritant to the eyes and not dermal sensitisers. The Panel could not conclude on the irritation potential to the eyes and the dermal sensitisation potential for the solid forms. Due to the proteinaceous nature of the active substance, the additive is considered to be a respiratory sensitiser. The additive has the potential to be efficacious in pigs for fattening at 20,000 BXU/kg complete feed, in all laying poultry species at 12,000 BXU/kg complete feed and in minor poultry species other than laying birds at 8000 BXU/kg complete feed.

Research on wax removal and prevention technology of White Wolf City oil well

Abstract Oil well wax removal technology is an important subject in the process of oil field exploitation. This paper analyzes the mechanism and characteristics of wax formation in oil Wells by measuring the amount of wax in crude oil in Baiwolcheng oil area. When the waxy component, which usually exists in liquid form, is accompanied by crude oil from underground to the ground, the waxy crystal precipitates and deposits in the inner wall of oil pipe due to the gradual decrease of the temperature of crude oil. The phenomenon of paraffin formation, paraffin formation process and paraffin formation law of oil well are studied, and chemical paraffin removal and anti-wax technology is determined as the main research object, evaluation and optimization of paraffin removal and anti-wax agent, and determination of dosage concentration and dosage.

Vehicle effect on in-vitro and in-vivo performance of spray dry dispersions

In early drug development, amorphous spray-dried dispersions (SDDs) applied to enhance the bioavailability of poorly water-soluble compounds are typically administered to preclinical species via oral gavage in the form of suspensions. The liquid formulations are usually prepared on the same day of dosing to minimize the exposure of the amorphous material to the aqueous vehicle, thereby reducing the risk of crystallization. Dose-ability (e.g. syringeability) of the suspensions is also a critical factor for the administration, particularly when high doses, thus concentrations, are required for toxicology studies. As a result, it is standard practice during early formulation screening to assess the stability and the maximum feasible concentration of SDDs in various vehicles. In this study, we evaluated the impact of different vehicles on the performance of a model SDD in-vitro and in-vivo settings, to mitigate the risks associated with its administration in liquid form. A poorly water-soluble compound (GEN-A) was selected to screen various SDDs and generate the SDD model at 30 % drug load with HPMCAS-MF polymer carrier. The SDD was suspended in selected aqueous vehicles after a careful vehicle components screening, that included suspending agents (HPC-SL), solubilizers (PEG400, Propylene glycol), surfactants (Vitamin E TPGS, SLS, Tween 80, Poloxamer 188), and complexing agents (HP-ꞵ-CD, SBE-ꞵ-CD). The suspensions were characterized for stability, dose-ability and dissolution in biorelevant media, prior administration in pre-clinical species. The SDD dissolution profile revealed that the drug's supersaturation level was positively impacted by the presence of a surfactant (SLS) and a complexing agent (SBE-ꞵ-CD) with respect to a suspending agents (HPC-SL) in the vehicle. Similarly, the pharmacokinetics profiles of the drug following the administration of the SDD in a vehicle with a complexing agent (SBE-ꞵ-CD) achieved greater exposure compare to the SDD in a vehicle with a suspending agent (HPC-SL). These findings confirm a synergistic effect between the SDD and the vehicles, suggesting that this combination could be leveraged to maximize the advantages of the amorphous approach.

Isolation and Antibacterial Activity of Sembung (Blumea balsamifera) Leaf Essential Oil L., DC

Sembung leaf essential oil is a complex mixture in the form of oily yellow liquid with a unique aroma. It contains various volatile components that have antibacterial, antifungal, antioxidant and cytotoxic activities. This study aims to determine the antibacterial activity of essential oil Blumea balsamifera L., DC against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Isolation of essential oil using steam distillation method with 0.21% rendement. Inhibition activity was performed by test tube method with variation concentrations of essential oil were 10%, 20%, 40%, 80%, and 100% for each bacteria. Results of this study showed that the highest antibacterial activity on Escherichia coli at 80% concentration with an inhibition zone diameter of 27.53 mm, 100% concentration for Pseudomonas aeruginosa with an inhibition zone diameter 25.72 mm and 100% concentration for Staphylococcus aureus with inhibition zone diameter 27.31 mm. Essential oil from (Blumea balsamifera) L., DC leaves have a strong activity inhibition category against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.

A Typical of Tsunami Generation Caused by Volcano Flank Collapse in Banda Neira, Maluku, Indonesia

Abstract The history eruption of the Banda volcanoes was recorded in 1632, 1816, and 1988 and was preceded by significant earthquakes. In the eruption in 2017, there were 28 volcanic earthquakes, indicating a rock cracking process due to the movement of magma in the form of gas, liquid, and rock solids. We suspect that when the earthquake occurs, the rock-cracking process upon the eruption will potentially trigger the volcano flank to collapse into the sea and generate a tsunami in the Banda Naira and surrounding area. We contribute to modeling the travel time and tsunami inundation resulting from the flank collapse of Banda Volcano. BATNAS bathymetry data is used to run tsunami simulations. We use aerial photography from field survey data to interpret Banda Volcano failure parameters, including diameter, direction of sliding of the collapse, and slope of the collapse of the side of the Banda Volcano. Based on the tsunami simulation, the volcano flank collapse source on Banda Volcano produced a maximum tsunami in Banda Naira as high as 6.2 meters, and the tsunami will arrive around 6 – 8 minutes. While in AI Island, tsunami inundation reached 55.87 m and arrived in 4 minutes. Meanwhile, the maximum elevation of Banda Naira Island is 3.5 meters, with a population of 21,000 people in March 2024. Tsunami inundation has the potential to submerge entire residential areas in Banda Neira.

Experimental and simulation study of magnesium phosphate cement two-liquid grouting materials

Magnesium phosphate cement (MPC) has a promising application in grouting. This study drew on the traditional cement-waterglass two-liquid grouting model. Creatively, the two main reaction components of MPC, dead-burned magnesium oxide and phosphate, were applied to the grouting field in a two-component liquid form. At the same time, through proportioning adjustment and experimental testing, we obtained A\B liquid components, which can be stabilized. In addition, MPC slurry was compared with the traditional grouting material, silicate cement slurry, to demonstrate its superiority. Finally, we simulated the grout diffusion process of the mixed slurry using the two-phase Darcy's law module of COMSOL Multiphysics subsurface fluids. The results show that the mixed slurry with a magnesium phosphate ratio of 1/3, a magnesium–boron ratio between 5% and 10%, and a water–cement ratio of 0.2–0.5 has better stability and mobility. Under the same fluidity, its strength is much higher than that of common silicate cement slurry and has good injectability. MPC was subjected to two-fluid grouting to take advantage of its fast-hardening and early-strengthening properties, while also improving its stability and fluidity. This study provided a theoretical foundation for the application of MPC.

The role of carbon textile surface functionalities in reactive adsorption of vapor and liquid 2-chloroethyl ethyl sulfide: Evaluating interactions at the interface

A carbon textile (CT) was chemically modified to increase its surface activity and promote the adsorption and degradation of 2-chloroethyl ethyl sulfide (CEES) - a surrogate for mustard gas. CT was initially subjected to oxidation (CTO), and then heated under ammonia (CTON) or hydrogen sulfide (CTOS) atmosphere to incorporate nitrogen or sulfur functionalities, respectively. Detoxification experiments were performed in closed vials using either vapor or liquid forms of CEES. The maximum vapor weight uptakes on CT, CTO, CTOS, and CTON were 399, 372, 434, and 489 mg/g, respectively. All textiles were able to prevent the vaporization of CEES liquid droplets. Although similar reaction products were detected in both vapor and liquid systems, the marked differences in the extent of CEES chemical transformation on the surfaces of the textiles indicate distinct detoxification pathways influenced by surface chemistry. Even though the heterogeneous surface of CTO, enriched with oxygen surface groups, facilitated various reactions, hydrolysis was the predominant pathway. The thermal treatment, regardless of the atmosphere, reduced the oxygen content, decreasing the extent of hydrolysis. However, incorporating basic surface groups such as pyridines, amines, or weak acids such as thiols promoted dehydrohalogenation as the main detoxification pathway on these samples.

Fabrication of injectable, adhesive, self-healing, superabsorbent hydrogels based on quaternary ammonium chitosan and oxidized pullulan

Injectable hydrogels, which are polymeric materials that are characterized by their ability to be injected in a liquid form into cavities and subsequently undergo in situ solidification, have garnered significant attention. These materials are extensively used in a range of biomedical applications. This study synthesized several injectable composite hydrogels through the mild Schiff base reaction while imposing different concentrations of quaternary ammonium chitosan and oxidized pullulan. Subsequent characterizations revealed a consistent and coherent porous structure within the hydrogels with smooth inner walls. The hydrogels were also determined to possess good adhesion, mechanical properties, self-healing ability, and injectability. Furthermore, antimicrobial tests against Escherichia coli and Staphylococcus aureus demonstrated antibacterial properties, which improved with increasing concentrations of quaternary ammonium chitosan. Co-culturing with skin fibroblasts demonstrated that the injectable hydrogels exhibited favourable biocompatibility and the capacity to boost cellular activity, thus underscoring its potential for use in biomedical applications.

Promising areas of slag processing in ferrous metallurgy

The characteristics of promising areas of slag processing in ferrous metallurgy are given. An increase in requirements for environmental protection was noted. Modern slag processing includes primary and secondary processing, which differ in the physical state of the slag. The technological foundations of mass processing of slag have been formed at the Ural Institute of Metals. An assessment of the state of slag processing shows that the capacity of crushing and screening plants, mainly due to complexes purchased abroad, exceeds the yield of slag of current production and leads to a decrease in dumps. Modern areas of economics and environmental protection require the creation and implementation of new technologies and equipment for the processing of slag in liquid and solid form, improving the quality of products at all stages of processing. Processing of slag in liquid form at furnace (or located near melting furnaces) plants will make it possible to organize the technological process in highly economical environmentally friendly small-sized units, to adjust the composition and properties of slag, to expand the range and quality of the resulting products, to create conditions for the utilization of melt heat and the recycling of slag processing products. These processes reduce the environmental burden on the environment, reduce material, energy and operational costs, and expand the range and quality of the products obtained