Background: Social support is a form of interpersonal relationship where the social environment provides assistance in the form of emotional attention, instrumental assistance, providing information, appreciation or assessment to individual sufferers. Lack of social support will lead to a decline in physical and mental conditions, which can cause a person to be lazy to carry out routine daily self-care activities. As a result, with HIV/AIDS do not adhere to treatment programs. If a person with HIV/AIDS does not regularly take anti-retroviral (ARV) for a long time, this will greatly affect the quality of life for with HIV/ AIDS. This study aims to examine the relationship between social support and quality of life in with HIV / AIDS. Subjects and Method: This was a meta-analysis study conducted by systematically reviewing articles from PubMed, Science Direct, Springer Link, and Google Scholar. The articles used in this research are articles that have been published from 2010-2020. The search for articles was carried out by considering the eligibility criteria using the PICO model, P: living with HIV/AIDS, I: strong social support, C: weak social support, O: Quality of life. The keywords for finding articles were as follows: people living with HIV/AIDS AND social support OR family support OR care relationship AND quality of life AND cross sectional AND multivariate . The inclusion criteria used were full paper, used English, cross-sectional study design and results reported adjusted odds ratio. Articles were collected using PRISMA diagrams, and analyzed using the Review Manager 5.3 application. Results: The meta-analysis was carried out on 8 articles in this study with a sample size of 2,719. The results of a meta-analysis with a cross-sectional study showed that living with HIV/AIDS with strong social support improved their quality of life (aOR= 2.82; 95% CI= 2.26 to 3.53; p <0.001). Conclusion: Strong social support can improve the quality of life for with HIV / AIDS. Keyword s : Quality of life, social support, with HIV / AIDS, meta-analysis Correspondence: Maria Regina Tri Yonita. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah, Indonesia. Email: mreginatry@gmail.com Journal of Epidemiology and Public Health (2020), 05(04): 435-441 https://doi.org/10.26911/jepublichealth.2020.05.04.05