The indigenous Baka Pygmies of southeast Cameroon depend mainly on environmental incomes for their livelihoods, usually hunting and gathering and the sustainable use of their ecological systems. They are at the verge of profound political, socioeconomic, and environmental transformations orchestrated by modern state laws regulating hunting and international development actors and agencies whose development vision expressed through conservation often underlie a contradiction with their way of life. This ethnographic study aims to document the dynamics of the institution of the great hunting expedition among the Baka. An interplay between the overexploitation of forestry resources, the creation of protected areas (fortress conservation), the full protection of certain classes of large mammals, the use of specific tools forbidden by existing forestry legislation and the ruthless behaviour of ‘eco-guards’ have led to changes in the organization of the great hunting expedition. To better address the socio-cultural aspects of biodiversity conservation and consequently strengthen the legislation regulating the wildlife sector in the country, conservation stakeholders must be conscious of the multiple entanglements between human and other life forms and the ecology of hunting. This suggests the need for a rights-based approach to conservation that recognizes the entanglement of ‘multispecies assemblages’ and respects indigenous land rights.