The effective management of dairy cattle requires study of alternative method therapy, one of which is the use of biogenic stimulators, for the treatment and prevention of functional disorders of the reproductive system in cows. Therefore, the purpose of our study was to investigate the effect of tissue preparations were made according to the method of Filatov in the modification of the Department of obstetrics and surgery of the Polissia National University on the biochemical blood composition in cows and to analyze the experience of their application for correction the course of pregnancy, prevention of infertility, treatment of obstetric-gynecological diseases and their prevention. The results of researches of the composition and experience of the application of tissue preparations made from uterus with contents, 3-5 months of pregnancy of clinically healthy cows and mares are presented in the article. It has been established that the composition of fetoplacentat and fetoplacentat-K include micro- and macroelements Cu, Pb, Cd, Zn, Mn, Co, Fe, Ca, P, K, Mg, Cd, follicle-stimulating, luteinizing hormones, oestradiol and progesterone. The clinical trials of fetoplacentat and fetoplacentat-K To, according to the developed schemes, were conducted more than 10 thousand heads of cattle, including 9.5 thousand cows and firstborn-cows and 700 heifers of the Simmental, Ukrainian red-pied and black-pied, Holstein dairy breeds in the farms of Polissya and in Zhytomyr forest-steppe region. It has been found that the high therapeutic efficacy in obstetric-gynecologic diseases of cows observed after the second and third injecting tissue preparations that show the occurrence and during the full stage of excitation of sexual cycle at 70% of cows, of which 84 % of the animals were fertilized. It has been shown that the using cows in the run and heifers in the last month of pregnancy tissue preparations in conjunction with trivitamin reduces the duration of the stages of calving at 33% and the time from calving to insemination, respectively by 11.3 %. However, it is worth noting that the using of tissue preparations fetoplacentat and fetoplacentat-K does not cause pathological processes in the organism of animals, including the occurrence of Allergy and irritation at the injection site. The analysis of the data clearly indicates that a three-fold introduction of fetoplacentat and fetoplacentat-K was caused the increase of the level of occurrence of biochemical processes in the organism of sterile cows and contributes to full-fledged stages of the sexual cycle and fruitful insemination of cows.
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