Forensic medicine is associated with the application of science to legal matters. One of the primary objectives of the judicial system is identifying a piece of evidence or an individual involved in a crime; forensic specialists play a critical role in this process. Legal odontology is one branch of forensic medicine and dentistry that focuses on using dentistry in the legal system. According to Interpol DVI regulations, dental features are one of the main components of identification. Consequently, the identification of unidentified human remains using dental features is one of the principal applications of legal odontology. The use of DNA as a human identifier, particularly in cases of severely decomposed, burned, or mutilated remains, has been made easier by recent developments in DNA technology and the use of saliva and teeth as sources of DNA. These developments also help to connect the criminal to the crime. In light of this, we provide a review of forensic genetics applications from the perspective of legal odontology here. In this review, results were manually extracted from articles indexed in the Scopus, PubMed, Google Scholar, and EBSCO databases that respond to the search terms that were carried out in English, Spanish, Mandarin Chinese, and French. Such as Forensic DNA, forensic genetics, legal odontology, forensic odontology, and dental DNA, to describe the medical-dental management of legal odontology to date.