The issues related to the principles of administrative and legal regulation of forensic activity in cases of administrative offenses related to traffic collisions are considered. Attention is focused on division of the principles of forensic activity into general and special ones. The general and special principles of administrative and legal regulation of forensic activity in cases of administrative offenses related to traffic collisions are defined. Currently, the number of traffic collisions in Ukraine is growing at a high pace resulting in increase in the number of trials on administrative offenses related to traffic collisions and, as a result, the number of road-accident analyses in cases of administrative offenses is increasing. Many scientists considered issues related to the principles of administrative and legal principles of administrative and legal regulation of forensic activity in cases of administrative offenses related to traffic collisions. In connection with the above, the issue of principles of administrative and legal regulation of forensic activity in cases of administrative offenses related to traffic accidents has become more topical. Research results have shown that special principles are closely linked to general principles. It was also established that general principles of administrative law which are applied in the field of administrative and legal regulation of forensic activity in cases of administrative offenses related to traffic collisions, are the principles of the rule of law, legality, independence; objectivity; research integrity, responsibility, independence. Accordingly, special principles are also independence, objectivity and integrity of research, the principle of integrated study of materials on cases of administrative offenses, the principle of narrow specialization. While conducting research, it also have been established that special principles are closely linked to general principles.