Introduction: the oil and gas region economy is highly dependent on tax revenues from oil and gas companies and their service companies, whose profits, in turn, are significantly affected by the volatility of oil and gas prices in the world commodity markets. This determines the relevance of developing new economic approaches to managing the production development of the oil and gas region, taking into account the principle of selectivity in terms of the ratio between the share of oil and gas in regional mining activities and the share of the main types of products of the oil and gas processing industry in the manufacturing industries of a particular region. Objectives: to clarify the scientific category “oil and gas region”, to substantiate and introduce into scientific circulation of the category “inclusive production development of the region” and to pose the problem of the concept “Groningen effect” acceptability at the regional level on the example of the Volga Federal District. Methods: synthesis of institutional, systemic, structural-functional and innovative-technological methodological approaches to managing the production development of the oil and gas region. The criteria for the analysis are the percentage components of the oil and condensate production volumes, as well as natural and associated petroleum gases, in the volume of final production in “Mining” sector. These indicators are mathematically interconnected with indicators of the structure of shipped products in the production of coke and oil products, rubber, and plastic products in the “Manufacturing production” sector; as a result, the region’s oil and gas activity factor was formulated. Results: the author revealed a characteristic of oil and gas region production development, which was called “inclusiveness”. It is based on the investment strategy of diversified high-yield oil and gas revenues of the regional budget into horizontal industrial policy, considering the economic and geological features of oil and gas resource extraction and their quality composition in the Volga-Ural oil and gas-bearing province. The paper proposes the scientific problem “Groningen effect” in the Russian regional conditions and estimates the magnitude of manifestation of said effect by the main types of foreign trade products of the oil and gas region. Conclusions: the developed approach to economic identification of the oil and gas region can become an effective instrument of selective management of its production development under conditions of high volatility of hydrocarbon raw materials quotations, the sanctions on Russian exports and the transition to technological sovereignty.