underwent Endoscopic ultrasound to rule out deeper layers invasion. Lesions with ultrasonographic or endoscopic signs of lipomas were excluded. The size range was 1 to 4 cm in diameter. In 10 cases submucosal injection with saline serum and epinephrine was performed. Access to the submucosa was obtained using a needle knife to cut the mucosa and then the dissection was performed using a combination of blunt instruments: biopsy, foreign body or electrocoagulation forceps depending on each case. Once the resection was completed the edges were approached with endoscopic clips. In three patients under general anesthesia a tunel disection of the submucosa was performed removing the complete lesion. The remaining patients were made under propofol sedation. Results: All the lesions were completely resected without complications. Of the esophageal lesions, 3 were reported as leiomyomas, 4 GIST and 1 germinal cells tumor; the gastric lesions were reported as 2 lipomas, 3 GIST and 1 leiomyoma. Conclusion: The endoscopic blunt dissection and resection of subepitelial lesions in the esophagus and stomach is in trained hands; safe and efficient as long as the endoscopic ultrasound demonstrate integrity of the muscularis propria layer. The complete resection of the specimen in “one pice” allows the correct pathology report. It looks reasonable to combine different dissection techniques depending on the localization, size or any other particular characteristic in each case.