The article discusses issues related to the trend of population loss in the Far East, how it affects the economy and living standards of the population, assess measures to contain outflows, formulate tasks that can make the region attractive to investors, the population, and those who want to come here. Causal links between the region's economic specialization and social living conditions are assessed. Efforts to improve life without changing the structure of production do not produce the desired result. It is argued that a change in the economic model, the transition from export-raw materials to industrial development, can change the nature of demographic processes and migration sentiments. Changing the economic paradigm opens the possibility to form a need for absolute population growth, to move from the task of "savings" to the multiplication of the people. The most important components of the new model: integration ties with the Asia-Pacific region, involvement in these processes economic and scientific, and technological potential of Russia, setting priorities. These are activities aimed at the development of the oceans and Cosmos, and Culture, where the country retains credibility in the world community, can be most effectively implemented leadership positions. A critical assessment of the existing spatial organization of life and activities in the Far East is needed. It is proposed to discuss adjustments to the administrative-territorial division, reducing the number of subjects of the federation, uniting or re-reporting some of them. The role-playing functions of the largest cities in the Far East, their specialization, and cooperation are discussed. The national task is proposed to assess the possibilities of forming a World City in eastern Russia in the future. This approach changes the perception of the Far East as a colonial-raw suburb, positioning it at the forefront of interaction with dynamic economies, where the potential for professional growth is superior to other regions of the country and is the main condition for achieving a high standard of living.