AbstractAnthropogenic changes can significantly alter estuarine environments and their fluvial–marine interactions. In this study, we investigate the evolution of wave impacts on the Modaomen Estuary (Pearl River Delta, China) in response to man‐made changes by quantifying the relative strength of fluvial and wave forces and by analysing morphological changes. River sediment input to the estuary has decreased significantly due to dam construction and decreased sediment diversion at junctions of the estuary due to sand excavation. The nearshore wave power and potential maximum alongshore sediment transport have increased substantially due to an intensive seaward extension of the coastline caused by estuarine regulation projects. Consequently, the Modaomen Estuary has shifted from a river‐dominated environment to one alternately controlled by wave and river effects, with waves being dominant in the dry season. Morphological alterations due to anthropogenic modifications in the Modaomen Estuary are characterized by a rotation of shoals from perpendicular to the coast to parallel to the coast, a straightening of the shoreline, and development of an asymmetrical subaqueous delta with a strong littoral drift, indicating evident wave impacts on estuarine morphological evolution.