For specific missions of spacecraft including on-orbit assembly, docking, grasp, etc., the presence of uncertainties leads to difficulties in the analysis of impedance force control systems and evaluations of safety for space manipulators. Therefore, in this study, a novel interval uncertainty-oriented impedance force control method for space manipulators with time-dependent reliability was established. The proposed method can accurately and rapidly characterize uncertainties. Additionally, it can reflect the reliability of a control system based on an overall time history. Once the uncertainties of the dynamic models and state responses are known, their uncertainty bounds can be obtained using an established non-probabilistic propagation method with high accuracy. An interval process model and the first passage theory are employed in the non-probabilistic time-dependent model. A joint reliability index is established based on the single reliability indexes, which can more efficiently evaluate the control system reliability than the individual indexes. A numerical example related to space manipulator is used to study the developed impedance force control method and verify the effectiveness of the method. The results from the response curves reveal validity of the proposed method, while the reduction in time proves efficiency of the method.