This study explores the utilization of African ostrich leg skins, sourced from South Africa, in the production of high-quality leather footwear in Ethiopia. It begins with a thorough analysis of the raw materials, particularly their fat and protein contents, while also evaluating the most effective tanning methods. The research focuses on the impact of chrome and semi-chrome tanning on the leather’s physical and structural qualities, highlighting its unique texture and durability. Through comprehensive trials conducted in Ethiopia, the study examines the leather’s thermal stability, fiber structure, and performance metrics. The results reveal that chrome tanning is better suited for producing footwear, as it enhances leather strength and yields leather with minimal stretch, making it ideal for crafting durable upper shoe components. On the other hand, semi-chrome tanning, as evidenced by scanning electron microscopy, yields softer leather with better fiber separation, suitable for luxury leather bags’ decorative features. The findings demonstrate that specialized tanning techniques can enhance both the aesthetic and functional attributes of ostrich leg leather, promoting its inclusion in high-end leather products. This approach not only broadens the variety of materials for the Ethiopian leather industry but also supports economic growth and market expansion through sustainable practices and product innovation.