Despite plastic being one of the most used materials globally, information about plastic flows in value chains is generally lacking. The present study aims at estimating the European Union (EU) plastic footprint (including production and consumption flows) by combining different approaches, as well as at estimating marine littering potentials. Plastic flow estimates build on a literature review of studies on material flows analysis to gather available data. The review highlights the lack of complete and homogeneous estimates of EU plastic production and consumption, as well as detailed figures for specific sectors (e.g., fishing, healthcare, electrical and electronic equipment). Data retrieved from literature were compared with estimates based on consumption statistics (i.e., PRODCOM database). Estimates for 2014 based on literature equals to 84 kg/person, whilst results derived from PRODCOM for the 2014 equals to 129 kg/person (with an average of 112 kg/person for the period 2010–2019). Packaging contributes to 27.9% of the overall footprint in the case of the literature-based approach (23.6% in the case of PRODCOM results), which is dominated by three polymers (LDPE, PP and PET). Concerning the marine litter potential, beach litter rates -based on EU beach litter observations and plastic statistics- were in the order of 10000 part per million of the consumed plastic.. This study unveiled that methodological improvements in estimates of the EU plastic footprint together with plastic littering potential, as well as further data gathering, are fundamental steps for fulfilling the EU ambitions to assess and reduce the environmental impacts of plastics.