Objective To investigate the status of sense of coherence (SOC) of the main caregivers of diabetic foot patients and explore the influencing factors. Methods Using convenient sampling method, 139 main caregivers of diabetic foot patients who were admitted to Shangqiu First People's Hospital from January 2018 to January 2019 and met the inclusion and exclusion criteria of this study were selected as the study objects. The patients were investigated with General Information Questionnaire, Zarit Caregiver Burden Interview (ZBI) and Sense of Coherence (SOC) . The influencing factors of SOC were analyzed by multiple linear regression and single factor analysis. Results The score of SOC of the main caregivers of diabetic foot patients was (61.71±8.73) and the score of ZBI was (26.16±12.93) . The course of disease, the average monthly income of the caregivers and the care burden were the main influencing factors of SOC of the main caregivers of diabetic foot patients (P<0.05) . Conclusions Clinical nurses should pay attention to the burden of care, improve the level of SOC of caregivers, and then improve the quality of life of diabetic foot patients and their main caregivers. Key words: Diabetic foot; Caregiver burden; Sense of coherence; Influencing factors