The large territorial extent of our country has formed a certain resource potential for each region, which depends on the geographical, natural and climatic conditions, as well as the competitive advantages of the territory. The purpose of the research was to assess the degree of influence of the use of the resource potential of the territory on its food security in order to predict possible consequences when one of the determinants changes. The availability and use of production resources in the agricultural sector of the economics in the Kurgan region has been analyzed in the article. The evaluation of food security of the territory is based on the use of a set of indicators that reflect the physical and economics availability of food, the sufficiency and quality of consumption. Agricultural production had been increased by more than 30 % during the analyzed period, and the inflationary factor should be taken into account in this growth. With the existing programs to support agricultural producers there is no significant growth in the number of cattle and the area of crops in the region. According to the threshold values of the level of food self-sufficiency laid down by the Food Security Doctrine of the Russian Federation the current state of agriculture in the Kurgan region cannot meet the region’s demand for meat and meat products. In 2019 the level of food independence for grain was 174,4 %, and for potatoes – 105,8 %, which indicates the feasibility of exporting these types of agricultural products to other regions of Russia. The annual grain export potential in the Kurgan region is estimated in the range from 0,6 to 1 million tons of grain. The conclusions made allow us to assess the degree of correlation between the resource potential of the region and the level of food security, and to develop recommendations for improving food self-sufficiency.