Folliculosebaceous Cystic Hamartoma Research Articles

An uncommon folliculosebaceous cystic hamartoma on the lower extremity

Folliculosebaceous cystic hamartomas (FSCH) are a recently recognized cutaneous hamartoma comprised of follicular, sebaceous and mesenchymal elements. Only nine cases have been previously reported. The authors present a case of FSCH on the lower extremity in addition to a literature review. To further characterize the clinical, histological and immunohistological features of FSCH. The clinical, histological and immunohistological features of FSCH were evaluated and the literature reviewed. This lesion uncommonly presents as exophytic papules or nodules on the leg, and most commonly presents on the central part of the face. Clinical differential diagnoses included nevus, neurofibroma and adnexal tumour. The diagnostic microscopic features of infundibular cystic structures with attached sebaceous glands and characteristic stroma were present in all lesions. Many of the stromal spindle cells were CD34-positive. The FSCH is a recently recognized hamartoma comprised of follicular, sebaceous and mesenchymal elements. Although reported only rarely, its incidence is likely much higher. In the present patient, the FSCH was located in femoral region, which is very rare.

Giant genital variant of folliculosebaceous cystic hamartoma: successful management by CO2laser and acitretin therapy

Giant genital variant of folliculosebaceous cystic hamartoma: successful management by CO₂laser and acitretin therapy

Nevus lipomatosus cutaneous superficialis with folliculosebaceous cystic hamartoma

Nevus lipomatosus cutaneous superficialis with folliculosebaceous cystic hamartoma

A Case of Folliculosebaceous Cystic Hamartoma on the Right Nasal Ala

Folliculosebaceous cystic hamartoma is a rare cutaneous hamartoma comprised of follicular, sebaceous, and mesenchymal elements. It usually presents as an exophytic papule or nodule on the central part of the face. The histological findings are intradermal cystic structures lined by infundibular epithelium, numerous sebaceous lobules radiating from cystic structures and a surrounding stroma composed of mesenchymal changes, including variable proportions of fibrous, adipose, vascular and neural tissues. We herein report a case of folliculosebaceous cystic hamartoma in a 73-year-old man who presented with a skin-colored, dome-shaped papule on the right nasal ala. (Ann Dermatol (Seoul) 19(4) 170~172, 2007)

An uncommon folliculosebaceous cystic hamartoma on the lower extremity

An uncommon folliculosebaceous cystic hamartoma on the lower extremity

A Case of Folliculosebaceous Cystic Hamartoma

A Case of Folliculosebaceous Cystic Hamartoma

Folliculosebaceous Cystic Hamartoma on the Nipple

Lee, Seung Yoon MD; Lee, Doo Rak MD; You, Chung Eui MD; Park, Mi Youn MD, PhD; Son, Sook Ja MD, PhD Author Information

A case of genital folliculosebaceous cystic hamartoma with an unique aggregated manifestation

Folliculosebaceous cystic hamartoma (FCH) is a recently recognized cutaneous hamartoma composed of follicular, sebaceous and mesenchymal components, and usually occurring on the head and neck. We describe herein a case of FCH with an unique aggregated manifestation in a genital lesion. The patient was a 40-year-old woman with a genital lesion composed of a pedunculated nodule, a dome-shaped nodule and a subcutaneous nodule, measuring 5 cm in the greatest dimension. The largest, pedunculated nodule was histologically composed of an infundibulo-cystic structure with follicular, sebaceous and mesenchymal elements accompanied by cystic structures of various sizes lined by stratified squamous epithelium and follicular germinative cells suggesting follicular cysts. The dome-shaped nodule consisted of anastomosing strands of epithelial cells with follicular components. The subcutaneous nodule had two components, an infundibulo-cystic structure and a cyst lined by squamous epithelium. In our case, the unusual clinical feature of large and multiple nodules was due to the presence of several prominent hamartomatous cystic structures with FCH. This is the third case of giant FCH. The clinical presentation and location of giant FCH is unusual.

Two cases of folliculosebaceous cystic hamartoma.

Folliculosebaceous cystic hamartoma (FSCH) is a rare cutaneous hamartoma composed of dilated folliculosebaceous units associated with mesenchymal elements. Two cases of FSCH with typical histopathological features are reported. Patient 1 was a 60-year-old man presented with a normal skin-coloured asymptomatic nodule on his scalp. Patient 2 was a 70-year-old man with an asymptomatic nodule on his right auricle that had persisted for the previous 15 years. In all, 34 cases of FSCH have been reported in the English literature. Clinically, the lesions are asymptomatic, usually rubbery to firm in consistency, and usually occur on or above the neck (> 90%). Most lesions do not exceed 25 mm in diameter (> 90%). Histopathologically, FSCH shares several similar features to sebaceous trichofolliculoma, but it is usually possible to differentiate these two tumours.

Folliculosebaceous cystic hamartoma arising within a port-wine stain

A 34-year-old woman presented with 2-year history of a dome-shaped papule on a well-circumscribed, thickened, port-wine stain on the left side of the chin. Squeezing on the port-wine-stain plaque revealed many comedos within dilated follicular orifices. The papule was excised and submitted for histological examination. Histopathological study showed a lobular neoplasm, comprising dilated, cystic pilosebaceous structures surrounded by fibrous stroma, bearing the characteristics of folliculosebaceous cystic hamartoma. The reported case shows that, in addition to the vascular nature, both ectodermal and mesenchymal abnormalities may be involved in port-wine stains.

Giant folliculosebaceous cystic hamartoma

Giant folliculosebaceous cystic hamartoma

Giant folliculosebaceous cystic hamartoma of the upper extremity

Folliculosebaceous cystic hamartoma (FSCH) is a rare cutaneous hamartoma consisting of dilated folliculosebaceous units invested in mesenchymal elements. These lesions have a striking predilection for the central face and scalp of adults. The vast majority of lesions present as 0.5-1.5-cm papules or exophytic nodules. A single case of giant FSCH has been reported on the upper back. A 32-year-old woman presented with a (15 cm in greatest dimension) plaque-like, multinodular lesion on her left upper arm for several years. The lesion was clinically suspected to be a nevus sebaceus. The skin excision showed numerous dermal and subcutaneous dilated follicular structures with peripherally radiating sebaceous lobules, hair follicles, and surrounding mesenchymal elements consistent with FSCH. To our knowledge, this is the second case of giant FSCH. Our case is unique for its larger size, more plaque-like growth, and location on an extremity when compared to the seminal case of giant FSCH.

A Case of Folliculosebaceous Cystic Hamartoma on the Upper Back

A Case of Folliculosebaceous Cystic Hamartoma on the Upper Back

Folliculo‐sebaceous cystic hamartoma is a trichofolliculoma at its very late stage

Folliculo-sebaceous cystic hamartoma (FCH) was described as an entity recently and was defined as an adnexal hamartoma, showing above all an infundibular cystic structure linked to many sebaceous lobules. Differentiation toward the inferior segment of the hair follicle also occurs, although to a markedly lesser degree. Signs of regression and rest corresponding to the normal follicular cycle are often apparent in these follicular proliferations. Therefore so-called FCH has much in common with the newly described late stage of trichofolliculoma, which also exhibits an infundibular cyst and sebaceous and follicular differentiation with various signs of catagen and telogen. Comparing our 8 cases of FCH and 31 cases of trichofolliculoma, we came to the conclusion that FCH is the very late stage of trichofolliculoma. This stage could be characterized by a nearly complete regression of the transient follicular epithelium, whereas concurrent growth and maturation of sebaceous elements appear.

Folliculo-sebaceous cystic hamartoma is a trichofolliculoma at its very late stage

Folliculo-sebaceous cystic hamartoma is a trichofolliculoma at its very late stage

Folliculosebaceous cystic hamartoma

Although folliculosebaceous cystic hamartoma (FCH) is an uncommon cutaneous entity with distinct classical and variant histopathologic features, it lacks distinctive typifying clinical features. Since the original description of five cases of FCH by Kimura et al. in 1991, 12 cases have been documented. We report a further case of FCH presenting as facial lesion in a 35 year old African male. FCH comprises prominent epithelial and mesenchymal components. The epithelial component is characterised by folliculosebaceous proliferation with cyst-like infundibular dilatation, and the mesenchymal component exhibits variable fibroplasia, vascular and neural proliferation and adipocyte metaplasia. Awareness of the lesion is important to avoid confusion with other cystic or cyst-like cutaneous lesions that contain prominent epithelial folliculosebaceous and variable mesenchymal components.

Folliculosebaceous cystic hamartoma: A clinical pathologic study

Background: Folliculosebaceous cystic hamartoma (FCH) is a recently recognized cutaneous hamartoma comprising follicular, sebaceous, and mesenchymal elements. Only nine cases have been previously reported. Objective: The aim of this study was to characterize further the clinical, histologic, and immunohistologic features of FCH. Methods: The clinical, histologic, and immunohistologic features of eight cases of FCH were evaluated and the literature reviewed. Results: All lesions presented as exophytic papules or nodules on the head, most commonly the central part of the face. Age at onset ranged from 4 to 47 years. The size ranged from 0.5 × 0.4 cm to 1.4 × 1.1 cm. Clinical diagnoses were nevus, neurofibroma, and adnexal tumor. None of the patients had associated Muir-Torre syndrome. The diagnostic microscopic features of infundibular cystic structures with attached sebaceous glands and characteristic stroma were present in all lesions. Many of the stromal spindle cells were CD34 positive. Conclusion: FCH is a recently recognized hamartoma of follicular, sebaceous, and mesenchymal elements. Although reported only rarely, its incidence is likely much higher.

Giant folliculosebaceous cystic hamartoma

We report a case of a giant cystic cutaneous adnexal hamartoma which showed fibrofollicular units embedded in the stroma with aberrant fat tissue. There were many sebaceous lobules in the fibrofollicular units, and its histologic features were consistent with conventional folliculosebaceous cystic hamartoma. Given the unique clinical history and appearance, this lesion is considered to be a congenital variant.

Folliculosebaceous Cystic Hamartoma Associated with Rosacea

A case of folliculosebaceous cystic hamartoma associated with rosacea is presented. Clinically, a solid, 5-mm-sized nodule was observed on the nose which showed telangiectasia and a waxy appearance. Histologically, a large horn cyst was located in the dermis, and was continuous with the surface epidermis. It was associated with mature sebaceous glands and immature hair follicles. Folliculosebaceous cystic hamartoma and similar cases have recently been reported, but this is the first report accompanied by rosacea.

Folliculosebaceous Cystic Hamartoma

The clinical and histological features of a recently recognized entity, folliculosebaceous cystic hamartoma, are reported. The peculiarity of our case is a previously unreported neural proliferation in the stroma.