to have incriminated p roperties and chemical constituents. In this study, t he crude methanolic extract of the A. humilis was evaluated for its possible cytotoxic, thrombolytic and antioxidant activities in different methods to justify some of its folklore use . Cytotoxic propert y of the extract was determined against brine shrimp nauplii. The thrombolytic activity was evaluated using the standard s treptokinase. The antioxidant activity was measured using free radical scaveng ing activity with 2 - 2 - diphenyl, 1 - picrylhydrazyl (DPPH) m ethod. The extract showed significan t cytotoxic effect in b rine s hrimp l ethality b ioassay where it showed the value of LC 50 and LC 90 2.26 µg/ml and 7.13 µg/ml after 24 hours respectively . The standard cytotoxic drug vincristine sulphate showed LC 50 and LC 9 0 of 0.81µg/ml and 6.33µg/ml after 24 hour respectively. The study gave a significant indication o f the use of the plant extract as a potential source for cytotoxic compounds. The extract showed moderate thrombolytic activity of 33.33 % clot lysis where the s tandard s treptokinase showed that of 84%. In DPPH free radical scavenging test, IC 50 value for the methanolic crude extract was found fairly significant ( 4. 305 µg/ml ) while compared to the IC 50 value of the reference standards ascorbic acid ( 2. 8 μg/ml ) . T he obtained results tend to suggest the probable c ytotoxic, thrombolytic and antioxidant activities of the methanolic extract of A. humilis justify its use in folkloric remedies and those activities of other species of Ardisia .