Field experiments were conducted at the Teaching and Research Farm of the Akwa Ibom State University, Obio Akpa Campus, between May, 2022 and October 2023, to examine the effects of seed size of fluted pumpkin and spatial placement of the seeds in the pod, on the emergence, growth and foliar yield of fluted pumpkin. The experiment consisted of three seed size categories (small, medium and large) and three spatial placement locations in the pod (Proximal section, Distal section and Middle section). The experiment was laid out in a randomized complete block design and replicated four times. Results indicated significant effects of spatial placement of seeds in the pod on some growth and yield parameters. Seeds from the middle section of the pod produced plants with the highest number of leaves (49.27), the widest stem girth (2.15cm) and the highest foliar yield (0.59 tones/ha). The size of seeds also significantly influenced the growth and foliar yield of fluted pumpkin. The large seeds produced plants with highest number of vines (5.10),the highest number of leaves (49.81), the highest seedling vigour index (8.78), the widest stem girth (1.26 cm) and the highest foliar yield (0.52 tons/ha). Farmers who are interested in producing fluted pumpkin vegetables are therefore advised to sow large seeds, and seeds from the middle section of the pod.