The Mapimí Biosphere Reserve is in northeastern México, near the boundary between the Mesozoic Coahuila platform and the Mexican central basin. A large portion of the Reserve is a broad bolson where isolated mountains are surrounded by flat terrain. Two slightly elevated areas (benches) are subtle topographic features in the Reserve. There, in rolling hills occur folded, Upper Cretaceous – Paleogene, poorly-lithified and -exposed transitional and continental sediments and tilted Paleogene volcanic and subvolcanic rocks. Each bench occupies a band that is ∼75 × 20 km. A land strip where playa lakes and salt-flats occur separates the benches. Deformation style within the benches differ from those in regions where platform carbonates or Mexican central basin rocks dominate. Structures within the benches are gentle, open folds and medium sized (15 - 3 km in diameter) structural domes and basins. Furthermore, orientation of the fold axes shows a wide scatter. There is at least one folded structure in the Reserve that displays an interference pattern that indicates refolding. Post-Oligocene normal faults bound the benches and overprinted on the folded structures. However, the most important normal fault, which cuts in half two domes and one structural basin, lacks a clear topographic scarp. The occurrence of broad exposures of the Upper Cretaceous Indidura Formation in flat areas, interpreted as the footwall block of a major normal fault, is consistent with the interpretation that the benches are rocky pediments partially covered by alluvium and/or eolian sediments. Thus, it appears that Cenozoic extension has been inactive for a long period of time in this portion of the Mexican Basin and Range province. The best evidence of NNW, down to the SW normal faults within the Reserve is in the Sierra de Mohóvano. There, an array of domino-style normal faults cut Oligocene volcanic rocks and gravel deposits. The master fault of the domino array is adjacent and parallel to a fold in Mesozoic marine rocks.We attribute the unusual characteristic of the folds in the Reserve to 1) the region is near the boundary among the large calcareous platform and the basin, and the boundary had a significant curvature, concave toward the W. This geometry caused complex deformation during crustal shortening, as tectonic transport associated with the Mexican orogen is toward the NE, 2) a significant difference in competence between the poorly consolidated transitional and continental deposits and the more competent rocks in the carbonate platform also played a role in the formation of the structures, as folds in the benches formed during the waning stage of the Mexican orogen, as suggested by the detrital zircon U–Pb ages, which are as young as ∼30 Ma, 3) Oligocene magmatic activity caused the emplacement of laccoliths, which locally modified older folds forming domes, 4) finally, Basin and Range extension (<27 Ma) cut across the folded sediments and overlying volcanic rocks. Evidence of extension in the Reserve is subtle as normal faults have remained inactive for a long time, while isostatic uplift and erosion developed the pediment, effectively masked most fault scarps.