Detailed measurements have been made of the magnetic field (0<H<6 T) and temperature (10 K<T<100 K) dependencies of the critical current density jc in Tl2CaBa2Cu2O8 films before and after irradiation with incremental fluences (0<Φ<3×1016 cm−2) of 2 MeV protons. The results are interpreted quantitatively in terms of radiation-induced changes in (1) the critical temperature, (2) the rate of thermal flux creep, and (3) local scale superconductivity. Radiation-induced enhancements in jc are described by an expression which allows the fluence that maximizes jc to be predicted as a function of H, T, pinning energy, and particle type.