Fluorine chemical shifts are reported as a function of solvent composition for dilute solutions of 6,6,6-trifluoro-l-hexanol in mixtures of water and organic liquids, mainly at 35°C. The cosolvents are acetone, dioxane, tetrahydrofuran, ethylene glycol, 2-methoxyethane, 1,2-dimethoxyethane, methanol, t-butanol, dimethyl formamide, and dimethyl sulfoxide. The data are interpreted assuming that they reflect primarily variations of the shielding contributions arising from bulk magnetic susceptibility and dispersion interactions. The shapes of the curves of shift versus composition depend greatly on the nature of the cosolvent, and they can be explained only by invoking several types of structural effects, similar to those suggested by other work on water-cosolvent systems. A few observations at 10°C and some data for D 2O-cosolvent mixtures are consistent with the finding that structural effects are enhanced by reducing the temperature or substituting D 2O for H 2O. The results are helpful in evaluating the merits and deficiencies of proposed methods of using 19F NMR shifts to measure the extent of exposure to water of a fluorine-containing probe molecule bound to a micelle, lipid vesicle, or protein.