A 30-year-old man presented to his local district general hospital with a week-long history of headache, cough and coryzal symptoms, followed by 24 hours of fever, neck stiffness, photophobia, confusion and agitation. He had no significant previous medical history. Examination revealed a Glasgow Coma Score of 11 (E4, M5, V2), stiff neck, tachypnoea and tachycardia. There were no localizing neurological signs. Mucus was crusted around the nose. The patient was sedated and ventilated in intensive care and given intravenous benzylpenicillin and cefotaxime. He then underwent a computed tomography (CT) head scan, which suggested fluid in the paranasal sinuses and pus filling the maxillary antrum. CSF was turbid, containing 16 000 white cells/mm3 (97% polymorphs), protein 3.22 g/litre and glucose 0.1 mM although no organisms were seen on Gram stain. At this point the patient was transferred to a tertiary neurology centre, where a repeat CT after 3 days showed further fluid and oedema in the paranasal sinuses. Sinus washout was performed and nasal decongestants prescribed. Initial attempts at extubation led to repeated seizures. Blood tests performed included assessment of pituitary profile, which was unremarkable. Sedation was withdrawn 10 days after admission and the patient extubated; once awake it became clear that he was blind. The patient was pyrexial (38°C), agitated and hallucinating. It was thought that he had Anton's syndrome (cortical blindness and poor awareness of blindness). He was transferred to a neurology ward and a low-dose antipsychotic was started. The patient became more alert and orientated, and able to cooperate with ophthalmological examination, which established healthy optic discs, no intraocular abnormality, no papilloedema and no afferent papillary defect, supporting the diagnosis of cortical blindness. A repeat CT scan to investigate his continuing headache demonstrated loss of radiolucency of all the paranasal sinuses and the patient underwent functional endoscopic sinus surgery; this involved bilateral eithmoidectomy, sphenoidectomy and insertion of stents into both frontal sinuses. An audiogram demonstrated high frequency sensorineural deafness. The patient's condition improved and his eyesight partly recovered (visual acuity 6/60 right eye and 6/24 left eye). Further ophthalmology examination revealed bilateral disc pallor and optic atrophy was diagnosed. It was noticed that this patient's skin had become soft, pale and wrinkled and he was shaving less frequently than usual. On the basis of his skin appearance, a diagnosis of possible hypopituitarism was made, and pituitary hormone profile was assessed. This revealed panhypopituitarism and magnetic resonance imaging confirmed the presence of gross inflammation in the optic chiasm and around the pituitary, although the pituitary gland itself appeared intact (Figure 1). The patient was discharged home on pituitary replacement therapy with planned regular follow-up.
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