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Analysis of lymphatic protein flux data III. Use of the nonlinear flux equation to estimate σ and PS

This paper introduces the use of the nonlinear or exact flux equation for determining estimates of the solvent drag reflection coefficient ( σ f) and the permeability-surface area product (PS) of the capillary membrane from lymphatic protein and fluid flux rates. In the past, a linearized version of the nonlinear flux equation has been used; however use of the linear equation has been problematic since there are a variety of definitions for C , the average protein concentration in the pore. The benefits of the exact equation in comparison with the linear equation are that (1) it more closely represents the physical processes occurring as the solute crosses the membrane, and (2) it eliminates the long standing problem with defining C . In general, the value of σ f determined with the exact flux equation is closer to one than those found with the most frequently used form of the linear flux equation.