A mathematical model has been constructed to examine the creeping sinusoidal flowing and diffusion of a solute material of an incompressible couple-stress fluid across a porous medium with wall features in the existence of heterogeneous-homogeneous chemical reaction. The mean effective diffusion factor is calculated using the long wavelength hypothesis, Taylor’s limit criteria, and dynamic periphery restrictions. The graphs have been used to study the effects of important constraints on the mean effective diffusion coefficient. The mean effective diffusion factor is found to rise with wall characteristics and amplitude ratio, indicating that peristalsis causes an increase in scattering. Additionally, scattering increased with the permeability constraint but decreased with the couple-stress constraint, homogeneous reaction rates, and heterogeneous reaction rates.