Using an air-water mixture and 34 mm ID pipe, a series of pressure drop and void fraction measurements were collected. The observed flow regimes were falling film, annular, bubbly, cap bubble, slug, and churn flows. The temporal fluctuations of void fraction and pressure drop measurements were firstly studied using signals visualization and PDF. It was revealed that both signals can be used to identify the flow regimes. A new flow pattern map is proposed based on the Froude number, calculated using the mixture velocity of the two phases, and the ratio of gas-to-liquid superficial velocities. The behaviors of the total and frictional pressure drops were studied and the influence of the superficial velocities as well as the flow regimes were identified. The experimental results were compared to four existing vertically downward frictional pressure drop models, none of which provided accurate predictions.