Objective To explore the curative effect of fibular flap with limbs composite soft-tissue. Methods From February, 2013 to February, 2016, 13 cases with body severe trauma patients were treated, which including 5 cases of upper limbs and 8 cases of lower limbs,and all existed bone defect, soft tissue defect and trunk vessel defect. Three cases with limbs distal non blood supply were emergency treated with debridment and flow-through fibular flap transplantation renovation,peroneal artery repairing defective blood vessels to restore limbs distal blood supply, fibular flap repairing bone defect, skin flap repairing soft tissue defect. The limb blood supply for other 10 cases were in good condition, but one case with main artery defect did the second phase of fibular flap transplantation and repaired defective blood vessels, bone and skin soft tissue synchronously according to wound condition. According to the postoperative observation for flap survival and appearance, X -ray films to observe fracture healing after 6 weeks, three months and 6 months of operation as well as evaluating limb function recovery, then analyzed the results. Results Flaps survived successfully for 11 cases, and flaps for the other 2 cases were partial necrosis. One Case was edge flap necrosis, heal scabby after dressing, and the other case was necrosis for 1/3 of the area, but the deep fascia survival,and the skin graft healing after dressing. One case with forearm rolling was in vascular crisis after operation, but the crisis was relieved after detection, and fingers blood supply was recovered. All the patients were followed up for 6 to 36 months(mean,14 months ). All flaps were survived, fractures healed well and limbs distal blood supply was good. Bone healing time was 8 to 24 weeks, and patients with lower limbs injury could bear load after 3 to 8 months. Lower limbs restored walking function. Upper limbs and hands restored rotation function. Transplant flapshad good e-lasticity and satisfactory appearance. Conclusion Using fibular flap to repair defective blood vessels, bone and soft tissue synchronously, not only can rescue the limbs on the verge of amputation, but also can repair defective composite tissue and get a good prognosis. It is an effective method for open injuries severely treatment in clinic. Key words: Fibular flap; Limbs; Reconstruction; Microsurgical technique