Cu-Ni binary alloy has become the attention of scientific world for its potentials in nanodevices. It is indispensable to investigate on the mechanical properties of this material due to lack of previous work done regarding this binary alloy. Molecular dynamics (MD) studies were performed on nanopillar (NP) structures comprised of Cu-Ni binary alloy having an FCC unit cell with Cu atoms selectively replaced by Ni atoms. This selective replacement resulted in a better stress behavior than the randomly replaced alloy structure when both tension and compression load were applied. The effect of crystal orientation, NP dimensions, temperature, and strain rate on the stress-strain curve of Cu-Ni binary alloy NPs was thoroughly investigated under tensile loading. This investigation reveals significant influence of crystal orientation on ultimate strength and flow stress region. Among four different crystal orientations, <111> orientation shows maximum strength behavior under tensile loading, while <110> shows highest strength under compressive load. However, in both cases, i.e. tension and compression, the poorest stress behavior was observed for <001> orientation. Under tensile load, <111>-oriented binary alloy fails due to the formation of Shockley partials followed by formation of complex dislocation network. On the other hand, <110>-oriented binary alloy fails due to the formation of Lomer-Cottrell (LC) lock from the Shockley partials. Total dislocation length is calculated, and its effect on the stress-strain behavior of the Cu-Ni binary alloy is discussed. Highest Young's modulus and yield stress are observed on <111>-oriented binary alloy among other orientations, and these values for <111>-oriented NP was found to decrease with the increment of temperature. If the temperature is increased, yield stress and Young's modulus decrease. The effect of cross section width was also investigated in this study, and it was found that yield stress decreases with the increment of cross section width due to the effect of surface atom fraction. Increasing the strain rate causes the initiation of amorphous structure, resulting in superplastic behavior of the <111>-oriented Cu-Ni binary alloy NP.